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Protein

Phosphoadenosine phosphosulfate reductase

Gene

cysH

Organism
Streptomyces scabiei (strain 87.22)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reduction of activated sulfate into sulfite.UniRule annotationSAAS annotation

Catalytic activityi

Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.UniRule annotationSAAS annotation

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes sulfite from sulfate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase subunit 1 (cysN)
  2. Adenylyl-sulfate kinase (cysC)
  3. Phosphoadenosine phosphosulfate reductase (cysH)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00140; UER00206.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoadenosine phosphosulfate reductaseUniRule annotation (EC:1.8.4.8UniRule annotation)
Alternative name(s):
3'-phosphoadenylylsulfate reductaseUniRule annotation
PAPS reductase, thioredoxin dependentUniRule annotation
PAPS sulfotransferaseUniRule annotation
PAdoPS reductaseUniRule annotation
Gene namesi
Name:cysHUniRule annotationImported
Ordered Locus Names:SCAB_19791Imported
OrganismiStreptomyces scabiei (strain 87.22)Imported
Taxonomic identifieri680198 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001444 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi680198.SCAB_19791.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 226PAPS_reductInterPro annotationAdd BLAST163

Sequence similaritiesi

Belongs to the PAPS reductase family. CysH subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105ET3. Bacteria.
COG0175. LUCA.
HOGENOMiHOG000249397.
KOiK00390.
OMAiVGDWHSS.
OrthoDBiPOG091H04I4.

Family and domain databases

CDDicd01713. PAPS_reductase. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00063. CysH. 1 hit.
InterProiView protein in InterPro
IPR004511. PAPS/APS_Rdtase.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF01507. PAPS_reduct. 1 hit.
PIRSFiPIRSF000857. PAPS_reductase. 1 hit.
TIGRFAMsiTIGR00434. cysH. 1 hit.

Sequencei

Sequence statusi: Complete.

C9YUJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVQADSGT SASSPDTAGQ DEARRAELRA LAEQAGRDLE DASALEILQW
60 70 80 90 100
AADTFGERFC VTSSMEDAVV AHLASRARPG VDVVFLDTGY HFPETIGTRD
110 120 130 140 150
AVEAVMDVNL VTITPRQTVA EQDAEYGPRL HDRDPDLCCF LRKVKPLEEG
160 170 180 190 200
LARFDAWATG LRRDESASRA DTPVVGWDDK RGKVKVSPIA RWTQDDVDAY
210 220 230 240 250
VAEHGVLTNP LLMDGYASVG CAPCTRRVAP GEDARAGRWA GNAKTECGLH

L
Length:251
Mass (Da):27,186
Last modified:November 24, 2009 - v1
Checksum:i3A5263ADAA476ECC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554889 Genomic DNA. Translation: CBG69099.1.
RefSeqiWP_012999823.1. NC_013929.1.

Genome annotation databases

EnsemblBacteriaiCBG69099; CBG69099; SCAB_19791.
GeneIDi24306106.
KEGGiscb:SCAB_19791.

Similar proteinsi

Entry informationi

Entry nameiC9YUJ9_STRSW
AccessioniPrimary (citable) accession number: C9YUJ9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: September 27, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported