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C9YRN8 (C9YRN8_CLODR) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cobyrinic acid A,C-diamide synthase HAMAP-Rule MF_00027
Gene names
Name:cbiA EMBL CBE07201.1
Synonyms:cobB HAMAP-Rule MF_00027
Ordered Locus Names:CDR20291_3256
OrganismClostridium difficile (strain R20291) [Complete proteome] [HAMAP]
Taxonomic identifier645463 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Peptostreptococcaceae ›

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation By similarity. HAMAP-Rule MF_00027

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis. HAMAP-Rule MF_00027

Sequence similarities

Belongs to the CobB/CobQ family. CobB subfamily. HAMAP-Rule MF_00027

Contains 1 GATase cobBQ-type domain. HAMAP-Rule MF_00027 SAAS SAAS011698

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain266 – 460195GATase cobBQ-type By similarity HAMAP-Rule MF_00027

Sites

Active site3481Nucleophile By similarity HAMAP-Rule MF_00027
Active site4521 By similarity HAMAP-Rule MF_00027

Sequences

Sequence LengthMass (Da)Tools
C9YRN8 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: CB126F8774180B01

FASTA47153,405
        10         20         30         40         50         60 
MMTFIYNLGR RCIMKKILIA GTNSGVGKTT ISLGIMQALV KRNMKVQPYK VGPDYIDPSY 

        70         80         90        100        110        120 
HTFITGRHSR NLDSYMLDDE KIKYIVNKSS KDADISVIEG VMGLYDGFGI DLDNCTSSHT 

       130        140        150        160        170        180 
SKVLKSPVIL VINGKSMAAS SAAMVLGYKE LDKDVNIKGV IVNNVKTNSH YQIIKSSIEK 

       190        200        210        220        230        240 
YCNVEVLGYF PPNNKFSLES RHLGLVPSVE MKSLREKFYT LADEIEHYID IDRIIEISES 

       250        260        270        280        290        300 
DEFESDFDFQ TLIENNKIKE HVNNKSIAIA YDKAFNFYYR ENIELLEELG LEINYFSPLE 

       310        320        330        340        350        360 
DASVPNADYI YIGGGFPEIF GKELEANESM RTSILEAHNN NIPIYAECGG LMYLGEKLLN 

       370        380        390        400        410        420 
QEEQEFNMVG IFSGISKMTS SLKRFGYCIG VAKENTLLSK KGESIKGHEF HHSIFESDEK 

       430        440        450        460        470 
CVYSMRKERD GNIVEEWDGG YSKGNTLATY LHTHFYNNLN CIENFLKKGN E

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References

[1]"Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium."
Stabler R.A., He M., Dawson L., Martin M., Valiente E., Corton C., Lawley T.D., Sebaihia M., Quail M.A., Rose G., Gerding D.N., Gibert M., Popoff M.R., Parkhill J., Dougan G., Wren B.W.
Genome Biol. 10:R102.1-R102.15(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R20291.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN545816 Genomic DNA. Translation: CBE07201.1.
RefSeqYP_003219731.1. NC_013316.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING645463.CDR20291_3256.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBE07201; CBE07201; CDR20291_3256.
GeneID8469562.
KEGGcdl:CDR20291_3256.
PATRIC19460623. VBICloDif78408_3453.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1797.
HOGENOMHOG000289958.
KOK02224.
OMACWLPGGY.

Enzyme and pathway databases

BioCycCDIF645463:GJP4-3340-MONOMER.
UniPathwayUPA00148.

Family and domain databases

HAMAPMF_00027. CobB.
InterProIPR004484. CbiA_synth.
IPR017929. CobB/CobQ_GATase.
IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
IPR011698. GATase_3.
[Graphical view]
PfamPF01656. CbiA. 1 hit.
PF07685. GATase_3. 1 hit.
[Graphical view]
TIGRFAMsTIGR00379. cobB. 1 hit.
PROSITEPS51274. GATASE_COBBQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC9YRN8_CLODR
AccessionPrimary (citable) accession number: C9YRN8
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: May 1, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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