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C9YPW4 (C9YPW4_CLODR) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase HAMAP-Rule MF_00127

EC=6.1.1.21 HAMAP-Rule MF_00127
Alternative name(s):
Histidyl-tRNA synthetase HAMAP-Rule MF_00127
Gene names
Name:hisS HAMAP-Rule MF_00127 EMBL CBE06103.1
Ordered Locus Names:CDR20291_2629 EMBL CBE06103.1
OrganismClostridium difficile (strain R20291) [Complete proteome] [HAMAP] EMBL CBE06103.1
Taxonomic identifier645463 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceae

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP-Rule MF_00127

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00127

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00127 SAAS SAAS015807.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. HAMAP-Rule MF_00127

Sequences

Sequence LengthMass (Da)Tools
C9YPW4 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 498D3EED8FB5E0ED

FASTA42047,737
        10         20         30         40         50         60 
MLTKAPRGTK DITPKEAYKW RYVENKFREI CALYGYEEMV TPIFEHTELF KRSVGDTTDI 

        70         80         90        100        110        120 
VQKEMYSFKD KGDREITLKP EGTAGVVRAF IENKLYADTQ PTKLFYVTPC FRYERPQAGR 

       130        140        150        160        170        180 
QRQFHQFGIE ALGSDTPSMD AEIIALAVQF FNEVGLNDLV VSINSVGCPV CRKEYNALLK 

       190        200        210        220        230        240 
EYLDSKADIL CDTCNERREK NPMRVIDCKN PTCKENIKDI PFIADHLCDD CKSHFDKLQE 

       250        260        270        280        290        300 
YLKEMNINFV IDKTIVRGLD YYRKTAFEII SNDIGAQSTV CGGGRYDGLV EQLGGPKGIS 

       310        320        330        340        350        360 
GIGFGLGIER LLLTLEGNGI EIENPQSTDI FIVTIGEEAN TRSFKLLKDL RQNHISADKD 

       370        380        390        400        410        420 
HIERSVKAQF KYSDKINSKF TIVIGDDELK NDTATLKNMK TSEQTTVKLS TLVEELKQKL 

« Hide

References

[1]"Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium."
Stabler R.A., He M., Dawson L., Martin M., Valiente E., Corton C., Lawley T.D., Sebaihia M., Quail M.A., Rose G., Gerding D.N., Gibert M., Popoff M.R., Parkhill J., Dougan G., Wren B.W.
Genome Biol. 10:R102.1-R102.15(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R20291 EMBL CBE06103.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN545816 Genomic DNA. Translation: CBE06103.1.
RefSeqYP_003219108.1. NC_013316.1.

3D structure databases

ProteinModelPortalC9YPW4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING645463.CDR20291_2629.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBE06103; CBE06103; CDR20291_2629.
GeneID8469521.
KEGGcdl:CDR20291_2629.
PATRIC19459289. VBICloDif78408_2789.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0124.
HOGENOMHOG000018072.
KOK01892.
OMACGGGNFK.
OrthoDBEOG6BPDH4.

Enzyme and pathway databases

BioCycCDIF645463:GJP4-2709-MONOMER.

Family and domain databases

Gene3D3.40.50.800. 1 hit.
HAMAPMF_00127. His_tRNA_synth.
InterProIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERPTHR11476. PTHR11476. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. SSF52954. 1 hit.
TIGRFAMsTIGR00442. hisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC9YPW4_CLODR
AccessionPrimary (citable) accession number: C9YPW4
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)