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C9YHT1 (C9YHT1_CLODR) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111
EC=2.5.1.7 HAMAP-Rule MF_00111
Alternative name(s):
Enoylpyruvate transferase HAMAP-Rule MF_00111
UDP-N-acetylglucosamine enolpyruvyl transferase HAMAP-Rule MF_00111
Gene names
Name:murA HAMAP-Rule MF_00111 EMBL CBE01674.1
Ordered Locus Names:CDR20291_0122
OrganismClostridium difficile (strain R20291) [Complete proteome] [HAMAP]
Taxonomic identifier645463 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Peptostreptococcaceae ›

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111 SAAS SAAS005750

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111 SAAS SAAS005750

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00111 SAAS SAAS005750.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily. HAMAP-Rule MF_00111

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1221Proton donor By similarity HAMAP-Rule MF_00111

Amino acid modifications

Modified residue12212-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity HAMAP-Rule MF_00111

Sequences

Sequence LengthMass (Da)Tools
C9YHT1 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 3485C5719B623FC4

FASTA42345,368
        10         20         30         40         50         60 
MRRSKNMAKI IVKKSNPLKG SVKIDGAKNA VLPIIAATLL ANGKSTLNGV PNLRDVHVIS 

        70         80         90        100        110        120 
DLLRHVGAEV EYKENTLTVD ASNIKTCEAP YELVRKMRAS FLVMGPLLAR FNSTKISMPG 

       130        140        150        160        170        180 
GCAIGTRPID LHLKGFKALG AKIEMDHGFV EAATEKLVGN KLYLDFPSVG ATENIMMAAS 

       190        200        210        220        230        240 
LAEGTTIIEN AAEEPEIVDL ANFLNEMGAD VKGAGTNTIK IKGVKELKGA EHNVIPDRIE 

       250        260        270        280        290        300 
AATYMVAAAM TKGDITVENV LMEHLKPVVA KLREAGCEIT EMDNSVRVVG PKVLKPIDIK 

       310        320        330        340        350        360 
TLPHPGFPTD VQAQFMAMLT VANGTGVVIE TVFENRFMHV AEFNRMGANI KIDGRSAVVN 

       370        380        390        400        410        420 
GVDELHGAAV NATDLRAGAA LILCGLIAEG ETQIGEIYHI QRGYVDIDKK ITALGGQIEI 


VED

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References

[1]"Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium."
Stabler R.A., He M., Dawson L., Martin M., Valiente E., Corton C., Lawley T.D., Sebaihia M., Quail M.A., Rose G., Gerding D.N., Gibert M., Popoff M.R., Parkhill J., Dougan G., Wren B.W.
Genome Biol. 10:R102.1-R102.15(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R20291.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN545816 Genomic DNA. Translation: CBE01674.1.
RefSeqYP_003216632.1. NC_013316.1.

3D structure databases

ProteinModelPortalC9YHT1.
ModBaseSearch...

Protein-protein interaction databases

STRING645463.CDR20291_0122.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBE01674; CBE01674; CDR20291_0122.
GeneID8466932.
KEGGcdl:CDR20291_0122.
PATRIC19453953. VBICloDif78408_0136.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0766.
HOGENOMHOG000075602.
KOK00790.
OMASIWALAP.

Enzyme and pathway databases

BioCycCDIF645463:GJP4-193-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC9YHT1_CLODR
AccessionPrimary (citable) accession number: C9YHT1
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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