Skip Header

Contribute Send feedback
Read comments (?) or add your own

C9Y4V2 (C9Y4V2_CROTZ) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Porphobilinogen deaminase HAMAP-Rule MF_00260
Short name=PBG HAMAP-Rule MF_00260
EC=2.5.1.61 HAMAP-Rule MF_00260
Alternative name(s):
Hydroxymethylbilane synthase HAMAP-Rule MF_00260
Pre-uroporphyrinogen synthase HAMAP-Rule MF_00260
Gene names
Name:hemC HAMAP-Rule MF_00260 EMBL CBA27057.1
Ordered Locus Names:Ctu_02370
ORF Names:CTU_02370 EMBL CBA27057.1
OrganismCronobacter turicensis (strain DSM 18703 / LMG 23827 / z3032) [Complete proteome] [HAMAP]
Taxonomic identifier693216 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Cronobacter ›

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps By similarity. HAMAP-Rule MF_00260 SAAS SAAS022419

Catalytic activity

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. HAMAP-Rule MF_00260 SAAS SAAS022419

Cofactor

Binds 1 dipyrromethane group covalently By similarity. HAMAP-Rule MF_00260 SAAS SAAS022419

Pathway

Porphyrin biosynthesis; chlorophyll biosynthesis. HAMAP-Rule MF_00260

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. HAMAP-Rule MF_00260 SAAS SAAS022419

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00260

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group By similarity. HAMAP-Rule MF_00260

Sequence similarities

Belongs to the HMBS family. HAMAP-Rule MF_00260

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Modified residue2421S-(dipyrrolylmethanemethyl)cysteine By similarity HAMAP-Rule MF_00260

Sequences

Sequence LengthMass (Da)Tools
C9Y4V2 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 99EFDD5C4C257AB8

FASTA31333,959
        10         20         30         40         50         60 
MLDNVLRIAT RQSPLALWQA QYVKQRLEAC HPGLTVELVP MVTRGDVILD TPLAKVGGKG 

        70         80         90        100        110        120 
LFVKELELAM LDGRADIAVH SMKDVPVEFP EGLGLVTICE REDPRDAFVS NRYKSLDEMP 

       130        140        150        160        170        180 
AGSIVGTSSL RRQCQIAARR PDLIIRSLRG NVGTRLSKLD NGDYDAIILA VAGLKRLQLD 

       190        200        210        220        230        240 
ARITSPLAPE ISLPAVGQGA VGIECRLDDT RTRELLAPLN HEETAVRVRA ERAMNTRLEG 

       250        260        270        280        290        300 
GCQVPIGSYA ELKDGELWLR ALVGAPDGSR IVRGERRGAP QDASQLGVSL AEELLNHGAR 

       310 
EILADVYQGN GPA

« Hide

References

[1]"The complete genome sequence of Cronobacter turicensis."
Tischler P., Lehner A., Rattei T., Stephan R.
Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 18703 / LMG 23827 / z3032.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN543093 Genomic DNA. Translation: CBA27057.1.
RefSeqYP_003208600.1. NC_013282.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING413502.Ctu_02370.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBA27057; CBA27057; CTU_02370.
GeneID8460720.
KEGGctu:CTU_02370.
PATRIC20401164. VBICroTur2449_0227.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000228588.
KOK01749.

Enzyme and pathway databases

BioCycCTUR693216:GI0P-2463-MONOMER.
UniPathwayUPA00251; UER00319.
UPA00668.

Family and domain databases

Gene3D3.30.160.40. 1 hit.
HAMAPMF_00260. Porphobil_deam.
InterProIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERPTHR11557. PTHR11557. 1 hit.
PfamPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSPR00151. PORPHBDMNASE.
SUPFAMSSF54782. Porphobil_deam. 1 hit.
TIGRFAMsTIGR00212. hemC. 1 hit.
PROSITEPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC9Y4V2_CROTZ
AccessionPrimary (citable) accession number: C9Y4V2
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info