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C9Y4V2

- C9Y4V2_CROTZ

UniProt

C9Y4V2 - C9Y4V2_CROTZ

Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Cronobacter turicensis (strain DSM 18703 / LMG 23827 / z3032)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotationSAAS annotation

    Catalytic activityi

    4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 dipyrromethane group covalently.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. hydroxymethylbilane synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidyl-pyrromethane cofactor linkage Source: InterPro
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Porphyrin biosynthesisUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCTUR693216:GI0P-249-MONOMER.
    UniPathwayiUPA00251; UER00319.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
    Short name:
    PBGUniRule annotation
    Alternative name(s):
    Hydroxymethylbilane synthaseUniRule annotation
    Pre-uroporphyrinogen synthaseUniRule annotation
    Gene namesi
    Name:hemCUniRule annotationImported
    Ordered Locus Names:Ctu_02370Imported
    ORF Names:CTU_02370Imported
    OrganismiCronobacter turicensis (strain DSM 18703 / LMG 23827 / z3032)Imported
    Taxonomic identifieri693216 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
    ProteomesiUP000002069: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei242 – 2421S-(dipyrrolylmethanemethyl)cysteineUniRule annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi413502.Ctu_02370.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMBS family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000228588.
    KOiK01749.
    OMAiGIECRTD.
    OrthoDBiEOG6HB9Z6.

    Family and domain databases

    Gene3Di3.30.160.40. 1 hit.
    HAMAPiMF_00260. Porphobil_deam.
    InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
    IPR022419. Porphobilin_deaminase_cofac_BS.
    IPR022417. Porphobilin_deaminase_N.
    IPR022418. Porphobilinogen_deaminase_C.
    [Graphical view]
    PANTHERiPTHR11557. PTHR11557. 1 hit.
    PfamiPF01379. Porphobil_deam. 1 hit.
    PF03900. Porphobil_deamC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
    PRINTSiPR00151. PORPHBDMNASE.
    SUPFAMiSSF54782. SSF54782. 1 hit.
    TIGRFAMsiTIGR00212. hemC. 1 hit.
    PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C9Y4V2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDNVLRIAT RQSPLALWQA QYVKQRLEAC HPGLTVELVP MVTRGDVILD    50
    TPLAKVGGKG LFVKELELAM LDGRADIAVH SMKDVPVEFP EGLGLVTICE 100
    REDPRDAFVS NRYKSLDEMP AGSIVGTSSL RRQCQIAARR PDLIIRSLRG 150
    NVGTRLSKLD NGDYDAIILA VAGLKRLQLD ARITSPLAPE ISLPAVGQGA 200
    VGIECRLDDT RTRELLAPLN HEETAVRVRA ERAMNTRLEG GCQVPIGSYA 250
    ELKDGELWLR ALVGAPDGSR IVRGERRGAP QDASQLGVSL AEELLNHGAR 300
    EILADVYQGN GPA 313
    Length:313
    Mass (Da):33,959
    Last modified:November 24, 2009 - v1
    Checksum:i99EFDD5C4C257AB8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN543093 Genomic DNA. Translation: CBA27057.1.
    RefSeqiWP_012814898.1. NC_013282.2.
    YP_003208600.1. NC_013282.2.

    Genome annotation databases

    EnsemblBacteriaiCBA27057; CBA27057; CTU_02370.
    GeneIDi8460720.
    KEGGictu:CTU_02370.
    PATRICi20401164. VBICroTur2449_0227.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN543093 Genomic DNA. Translation: CBA27057.1 .
    RefSeqi WP_012814898.1. NC_013282.2.
    YP_003208600.1. NC_013282.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 413502.Ctu_02370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBA27057 ; CBA27057 ; CTU_02370 .
    GeneIDi 8460720.
    KEGGi ctu:CTU_02370.
    PATRICi 20401164. VBICroTur2449_0227.

    Phylogenomic databases

    HOGENOMi HOG000228588.
    KOi K01749.
    OMAi GIECRTD.
    OrthoDBi EOG6HB9Z6.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00319 .
    BioCyci CTUR693216:GI0P-249-MONOMER.

    Family and domain databases

    Gene3Di 3.30.160.40. 1 hit.
    HAMAPi MF_00260. Porphobil_deam.
    InterProi IPR000860. 4pyrrol_synth_OHMeBilane_synth.
    IPR022419. Porphobilin_deaminase_cofac_BS.
    IPR022417. Porphobilin_deaminase_N.
    IPR022418. Porphobilinogen_deaminase_C.
    [Graphical view ]
    PANTHERi PTHR11557. PTHR11557. 1 hit.
    Pfami PF01379. Porphobil_deam. 1 hit.
    PF03900. Porphobil_deamC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
    PRINTSi PR00151. PORPHBDMNASE.
    SUPFAMi SSF54782. SSF54782. 1 hit.
    TIGRFAMsi TIGR00212. hemC. 1 hit.
    PROSITEi PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Cronobacter turicensis."
      Tischler P., Lehner A., Rattei T., Stephan R.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 18703 / LMG 23827 / z3032Imported.

    Entry informationi

    Entry nameiC9Y4V2_CROTZ
    AccessioniPrimary (citable) accession number: C9Y4V2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 24, 2009
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3