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C9Y4V2

- C9Y4V2_CROTZ

UniProt

C9Y4V2 - C9Y4V2_CROTZ

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Protein
Porphobilinogen deaminase
Gene
hemC, Ctu_02370, CTU_02370
Organism
Cronobacter turicensis (strain DSM 18703 / LMG 23827 / z3032)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps By similarity.UniRule annotationSAAS annotations

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotationSAAS annotations

Cofactori

Binds 1 dipyrromethane group covalently By similarity.UniRule annotationSAAS annotations

Pathwayi

GO - Molecular functioni

  1. hydroxymethylbilane synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. peptidyl-pyrromethane cofactor linkage Source: InterPro
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCTUR693216:GI0P-249-MONOMER.
UniPathwayiUPA00251; UER00319.

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
Short name:
PBGUniRule annotation
Alternative name(s):
Hydroxymethylbilane synthase
Pre-uroporphyrinogen synthase
Gene namesi
Name:hemCUniRule annotationImported
Ordered Locus Names:Ctu_02370Imported
ORF Names:CTU_02370Imported
OrganismiCronobacter turicensis (strain DSM 18703 / LMG 23827 / z3032)
Taxonomic identifieri693216 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
ProteomesiUP000002069: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei242 – 2421S-(dipyrrolylmethanemethyl)cysteine By similarityUniRule annotation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi413502.Ctu_02370.

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228588.
KOiK01749.
OMAiGIECRTD.
OrthoDBiEOG6HB9Z6.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam.
InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9Y4V2-1 [UniParc]FASTAAdd to Basket

« Hide

MLDNVLRIAT RQSPLALWQA QYVKQRLEAC HPGLTVELVP MVTRGDVILD    50
TPLAKVGGKG LFVKELELAM LDGRADIAVH SMKDVPVEFP EGLGLVTICE 100
REDPRDAFVS NRYKSLDEMP AGSIVGTSSL RRQCQIAARR PDLIIRSLRG 150
NVGTRLSKLD NGDYDAIILA VAGLKRLQLD ARITSPLAPE ISLPAVGQGA 200
VGIECRLDDT RTRELLAPLN HEETAVRVRA ERAMNTRLEG GCQVPIGSYA 250
ELKDGELWLR ALVGAPDGSR IVRGERRGAP QDASQLGVSL AEELLNHGAR 300
EILADVYQGN GPA 313
Length:313
Mass (Da):33,959
Last modified:November 24, 2009 - v1
Checksum:i99EFDD5C4C257AB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN543093 Genomic DNA. Translation: CBA27057.1.
RefSeqiWP_012814898.1. NC_013282.2.
YP_003208600.1. NC_013282.2.

Genome annotation databases

EnsemblBacteriaiCBA27057; CBA27057; CTU_02370.
GeneIDi8460720.
KEGGictu:CTU_02370.
PATRICi20401164. VBICroTur2449_0227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN543093 Genomic DNA. Translation: CBA27057.1 .
RefSeqi WP_012814898.1. NC_013282.2.
YP_003208600.1. NC_013282.2.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 413502.Ctu_02370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBA27057 ; CBA27057 ; CTU_02370 .
GeneIDi 8460720.
KEGGi ctu:CTU_02370.
PATRICi 20401164. VBICroTur2449_0227.

Phylogenomic databases

HOGENOMi HOG000228588.
KOi K01749.
OMAi GIECRTD.
OrthoDBi EOG6HB9Z6.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00319 .
BioCyci CTUR693216:GI0P-249-MONOMER.

Family and domain databases

Gene3Di 3.30.160.40. 1 hit.
HAMAPi MF_00260. Porphobil_deam.
InterProi IPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view ]
PANTHERi PTHR11557. PTHR11557. 1 hit.
Pfami PF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSi PR00151. PORPHBDMNASE.
SUPFAMi SSF54782. SSF54782. 1 hit.
TIGRFAMsi TIGR00212. hemC. 1 hit.
PROSITEi PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Cronobacter turicensis."
    Tischler P., Lehner A., Rattei T., Stephan R.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18703 / LMG 23827 / z3032.

Entry informationi

Entry nameiC9Y4V2_CROTZ
AccessioniPrimary (citable) accession number: C9Y4V2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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