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Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Siccibacter turicensis (strain DSM 18703 / LMG 23827 / z3032) (Cronobacter turicensis)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotationSAAS annotation

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotationSAAS annotation

Cofactori

dipyrromethaneUniRule annotationSAAS annotationNote: Binds 1 dipyrromethane group covalently.UniRule annotationSAAS annotation

Pathway:iprotoporphyrin-IX biosynthesis

This protein is involved in step 2 and 2 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Porphobilinogen deaminase (hemC), Porphobilinogen deaminase (hemC)
  3. no protein annotated in this organism
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Pathway:iprotoporphyrin-IX biosynthesis

This protein is involved in step 2 and 2 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.SAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Porphobilinogen deaminase (hemC), Porphobilinogen deaminase (hemC)
  3. no protein annotated in this organism
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotation

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCTUR693216:GI0P-249-MONOMER.
UniPathwayiUPA00251; UER00319.
UPA00251; UER00319.

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminaseUniRule annotationImported (EC:2.5.1.61UniRule annotationImported)
Short name:
PBGUniRule annotation
Alternative name(s):
Hydroxymethylbilane synthaseUniRule annotation
Pre-uroporphyrinogen synthaseUniRule annotation
Gene namesi
Name:hemCUniRule annotationImported
Ordered Locus Names:Ctu_02370Imported
OrganismiSiccibacter turicensis (strain DSM 18703 / LMG 23827 / z3032) (Cronobacter turicensis)Imported
Taxonomic identifieri693216 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSiccibacter
ProteomesiUP000002069 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei242 – 2421S-(dipyrrolylmethanemethyl)cysteineUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228588.
KOiK01749.
OMAiGIECRTD.
OrthoDBiEOG6HB9Z6.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam.
InterProiIPR000860. HemC.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9Y4V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDNVLRIAT RQSPLALWQA QYVKQRLEAC HPGLTVELVP MVTRGDVILD
60 70 80 90 100
TPLAKVGGKG LFVKELELAM LDGRADIAVH SMKDVPVEFP EGLGLVTICE
110 120 130 140 150
REDPRDAFVS NRYKSLDEMP AGSIVGTSSL RRQCQIAARR PDLIIRSLRG
160 170 180 190 200
NVGTRLSKLD NGDYDAIILA VAGLKRLQLD ARITSPLAPE ISLPAVGQGA
210 220 230 240 250
VGIECRLDDT RTRELLAPLN HEETAVRVRA ERAMNTRLEG GCQVPIGSYA
260 270 280 290 300
ELKDGELWLR ALVGAPDGSR IVRGERRGAP QDASQLGVSL AEELLNHGAR
310
EILADVYQGN GPA
Length:313
Mass (Da):33,959
Last modified:November 24, 2009 - v1
Checksum:i99EFDD5C4C257AB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN543093 Genomic DNA. Translation: CBA27057.1.
RefSeqiWP_012814898.1. NC_013282.2.

Genome annotation databases

EnsemblBacteriaiCBA27057; CBA27057; CTU_02370.
KEGGictu:CTU_02370.
PATRICi20401164. VBICroTur2449_0227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN543093 Genomic DNA. Translation: CBA27057.1.
RefSeqiWP_012814898.1. NC_013282.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBA27057; CBA27057; CTU_02370.
KEGGictu:CTU_02370.
PATRICi20401164. VBICroTur2449_0227.

Phylogenomic databases

HOGENOMiHOG000228588.
KOiK01749.
OMAiGIECRTD.
OrthoDBiEOG6HB9Z6.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00319.
UPA00251; UER00319.
BioCyciCTUR693216:GI0P-249-MONOMER.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam.
InterProiIPR000860. HemC.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Cronobacter turicensis."
    Tischler P., Lehner A., Rattei T., Stephan R.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18703 / LMG 23827 / z3032Imported.

Entry informationi

Entry nameiC9Y4V2_SICTZ
AccessioniPrimary (citable) accession number: C9Y4V2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: July 22, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.