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C9Y4V2

- C9Y4V2_CROTZ

UniProt

C9Y4V2 - C9Y4V2_CROTZ

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Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Cronobacter turicensis (strain DSM 18703 / LMG 23827 / z3032)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotationSAAS annotation

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotationSAAS annotation

Cofactori

Note: Binds 1 dipyrromethane group covalently.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. hydroxymethylbilane synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidyl-pyrromethane cofactor linkage Source: InterPro
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotation

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCTUR693216:GI0P-249-MONOMER.
UniPathwayiUPA00251; UER00319.

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
Short name:
PBGUniRule annotation
Alternative name(s):
Hydroxymethylbilane synthaseUniRule annotation
Pre-uroporphyrinogen synthaseUniRule annotation
Gene namesi
Name:hemCUniRule annotationImported
Ordered Locus Names:Ctu_02370Imported
ORF Names:CTU_02370Imported
OrganismiCronobacter turicensis (strain DSM 18703 / LMG 23827 / z3032)Imported
Taxonomic identifieri693216 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
ProteomesiUP000002069: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei242 – 2421S-(dipyrrolylmethanemethyl)cysteineUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi413502.Ctu_02370.

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228588.
KOiK01749.
OMAiGIECRTD.
OrthoDBiEOG6HB9Z6.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam.
InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9Y4V2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLDNVLRIAT RQSPLALWQA QYVKQRLEAC HPGLTVELVP MVTRGDVILD
60 70 80 90 100
TPLAKVGGKG LFVKELELAM LDGRADIAVH SMKDVPVEFP EGLGLVTICE
110 120 130 140 150
REDPRDAFVS NRYKSLDEMP AGSIVGTSSL RRQCQIAARR PDLIIRSLRG
160 170 180 190 200
NVGTRLSKLD NGDYDAIILA VAGLKRLQLD ARITSPLAPE ISLPAVGQGA
210 220 230 240 250
VGIECRLDDT RTRELLAPLN HEETAVRVRA ERAMNTRLEG GCQVPIGSYA
260 270 280 290 300
ELKDGELWLR ALVGAPDGSR IVRGERRGAP QDASQLGVSL AEELLNHGAR
310
EILADVYQGN GPA
Length:313
Mass (Da):33,959
Last modified:November 24, 2009 - v1
Checksum:i99EFDD5C4C257AB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN543093 Genomic DNA. Translation: CBA27057.1.
RefSeqiYP_003208600.1. NC_013282.2.

Genome annotation databases

EnsemblBacteriaiCBA27057; CBA27057; CTU_02370.
GeneIDi8460720.
KEGGictu:CTU_02370.
PATRICi20401164. VBICroTur2449_0227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN543093 Genomic DNA. Translation: CBA27057.1 .
RefSeqi YP_003208600.1. NC_013282.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 413502.Ctu_02370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBA27057 ; CBA27057 ; CTU_02370 .
GeneIDi 8460720.
KEGGi ctu:CTU_02370.
PATRICi 20401164. VBICroTur2449_0227.

Phylogenomic databases

HOGENOMi HOG000228588.
KOi K01749.
OMAi GIECRTD.
OrthoDBi EOG6HB9Z6.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00319 .
BioCyci CTUR693216:GI0P-249-MONOMER.

Family and domain databases

Gene3Di 3.30.160.40. 1 hit.
HAMAPi MF_00260. Porphobil_deam.
InterProi IPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view ]
PANTHERi PTHR11557. PTHR11557. 1 hit.
Pfami PF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSi PR00151. PORPHBDMNASE.
SUPFAMi SSF54782. SSF54782. 1 hit.
TIGRFAMsi TIGR00212. hemC. 1 hit.
PROSITEi PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Cronobacter turicensis."
    Tischler P., Lehner A., Rattei T., Stephan R.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18703 / LMG 23827 / z3032Imported.

Entry informationi

Entry nameiC9Y4V2_CROTZ
AccessioniPrimary (citable) accession number: C9Y4V2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3