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C9XRQ8 (C9XRQ8_CLODC) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Ribonuclease Ph EMBL CBA66330.1
Gene names
Name:rph EMBL CBA66330.1
Ordered Locus Names:CD196_3123
OrganismClostridium difficile (strain CD196) [Complete proteome] [HAMAP]
Taxonomic identifier645462 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Peptostreptococcaceae ›

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates By similarity. SAAS SAAS002381

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. SAAS SAAS020922

tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. SAAS SAAS002381

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. SAAS SAAS020922

Subunit structure

Homodimer By similarity. SAAS SAAS020922

Sequence similarities

Belongs to the HAM1 NTPase family. RuleBase RU003781

Sequences

Sequence LengthMass (Da)Tools
C9XRQ8 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 0F0A68EC1DCB9408

FASTA44950,066
        10         20         30         40         50         60 
MTRSYDRSNE QIRPVKITRD YTKYAEGSVL IEMGETKVIC TASVEEKVPP FLRNSGTGWI 

        70         80         90        100        110        120 
NAEYSMLPRA TQQRKIRDAS RGKIDGRTQE IQRLIGRAIR SVVDLNKLGE RTIWVDCDVI 

       130        140        150        160        170        180 
QADGGTRTAS ITGAFVAVAE AIYKLYKAKT IKEMPITNFV SAISVGIVNG IHMLDLCYEE 

       190        200        210        220        230        240 
DSKAQVDMNI IMTDKCEFVE VQGTGEEKPF SRADLNLLLE LGEKGNKELI RLQREALGEI 

       250        260        270        280        290        300 
ADEILGMDYG NEVVIATNNA HKLEEIGEIL KDFEYKVYSL KDVDLAGIEI VEDGKTFEHN 

       310        320        330        340        350        360 
ALIKARAIAK KTKLIAISDD SGLEVDALGK KPGVYSARYA GEHATDEENR KKLLKAMQNV 

       370        380        390        400        410        420 
PMSKRNARFV SAIAVVFPDG KEFVVRGICE GMIGFEEKGK NGFGYDSLFI VKGYDKTFGE 

       430        440 
IPSVIKNSIS HRANALKLMK QEFIKRVVK

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References

[1]"Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium."
Stabler R.A., He M., Dawson L., Martin M., Valiente E., Corton C., Lawley T.D., Sebaihia M., Quail M.A., Rose G., Gerding D.N., Gibert M., Popoff M.R., Parkhill J., Dougan G., Wren B.W.
Genome Biol. 10:R102.1-R102.15(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CD196.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN538970 Genomic DNA. Translation: CBA66330.1.
RefSeqYP_003216137.1. NC_013315.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING645462.CD196_3123.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBA66330; CBA66330; CD196_3123.
GeneID8465516.
KEGGcdc:CD196_3123.
PATRIC19452738. VBICloDif125228_3278.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0689.
HOGENOMHOG000122621.

Enzyme and pathway databases

BioCycCDIF645462:GJED-3212-MONOMER.

Family and domain databases

HAMAPMF_00564. RNase_PH.
MF_01405. Non_canon_purine_NTPase.
InterProIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR002381. RNase_PH_bac-type.
IPR018336. RNase_PH_CS.
[Graphical view]
PANTHERPTHR11067. PTHR11067. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
PF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMSSF55666. 3_ExoRNase. 1 hit.
SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR01966. RNasePH. 1 hit.
TIGR00042. TIGR00042. 1 hit.
PROSITEPS01277. RIBONUCLEASE_PH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC9XRQ8_CLODC
AccessionPrimary (citable) accession number: C9XRQ8
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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