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C9XQ44 (C9XQ44_PEPDC) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL CBA62427.1
Ordered Locus Names:CD196_1278 EMBL CBA62427.1
ORF Names:QGC_1251 EMBL EQF77307.1
OrganismPeptoclostridium difficile (strain CD196) (Clostridium difficile) [Complete proteome] [HAMAP] EMBL CBA62427.1
Taxonomic identifier645462 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain100 – 295196ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding127 – 18256ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2501Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2621Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2621Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2641Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C9XQ44 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 30E8FB3B65F0697D

FASTA29933,566
        10         20         30         40         50         60 
MKIAVIMGGI SSEREVSLNS GKEIYNNLDK NKYEVVKVII DDKKDIFTKI PEDIDFAILA 

        70         80         90        100        110        120 
LHGKFGEDGC IQSILETMDI PYSGCGPLCS GMCMDKNITK KMLRDSNLPT APWVLVKSVD 

       130        140        150        160        170        180 
EIDYDEIDNI GYPVFIKPNS GGSSVATFFI HSKDEVEEAV RKGLEVDEFV MIEKYIPGGE 

       190        200        210        220        230        240 
YTSFILNGEV FPTISIKSDS GFFDYEAKYS VEKGAKEEVV YLDEELQKRV NEISETCWKI 

       250        260        270        280        290 
FNCKAYVRVD MIISEGIPYV LELNTLPGMT QTSLIPRSAA ARGIKYSELL DKLIEYSLN 

« Hide

References

« Hide 'large scale' references
[1]"Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium."
Stabler R.A., He M., Dawson L., Martin M., Valiente E., Corton C., Lawley T.D., Sebaihia M., Quail M.A., Rose G., Gerding D.N., Gibert M., Popoff M.R., Parkhill J., Dougan G., Wren B.W.
Genome Biol. 10:R102.1-R102.15(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CD196 EMBL CBA62427.1.
[2]Walk S., Aronoff D., Young V.Y., Marsh J., Harrison L., Daugherty S.C., Shefchek K.A., Hine E.E., Tallon L.J., Sadzewicz L.K., Rasko D.A.
Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CD196 EMBL EQF77307.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN538970 Genomic DNA. Translation: CBA62427.1.
AVIE01000357 Genomic DNA. Translation: EQF77307.1.
RefSeqYP_003214307.1. NC_013315.1.

3D structure databases

ProteinModelPortalC9XQ44.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING645462.CD196_1278.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBA62427; CBA62427; CD196_1278.
EQF77307; EQF77307; QGC_1251.
GeneID8464139.
KEGGcdc:CD196_1278.
PATRIC19448819. VBICloDif125228_1325.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAGCDARSS.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycCDIF645462:GJED-1363-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC9XQ44_PEPDC
AccessionPrimary (citable) accession number: C9XQ44
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)