Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C9XNT4

- C9XNT4_PEPDC

UniProt

C9XNT4 - C9XNT4_PEPDC

Protein

1-deoxy-D-xylulose-5-phosphate synthase

Gene

dxs

Organism
Peptoclostridium difficile (strain CD196) (Clostridium difficile)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (24 Nov 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).UniRule annotationSAAS annotation

    Catalytic activityi

    Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotationSAAS annotation
    Binds 1 thiamine pyrophosphate per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei74 – 741Thiamine pyrophosphateUniRule annotation
    Metal bindingi146 – 1461MagnesiumUniRule annotation
    Metal bindingi175 – 1751MagnesiumUniRule annotation
    Binding sitei175 – 1751Thiamine pyrophosphateUniRule annotation
    Binding sitei287 – 2871Thiamine pyrophosphateUniRule annotation
    Binding sitei366 – 3661Thiamine pyrophosphateUniRule annotation

    GO - Molecular functioni

    1. 1-deoxy-D-xylulose-5-phosphate synthase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 1-deoxy-D-xylulose 5-phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
    3. thiamine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Isoprene biosynthesisUniRule annotationSAAS annotation, Thiamine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Thiamine pyrophosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCDIF645462:GJED-1153-MONOMER.
    UniPathwayiUPA00064; UER00091.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthaseUniRule annotation (EC:2.2.1.7UniRule annotation)
    Alternative name(s):
    1-deoxyxylulose-5-phosphate synthaseUniRule annotation
    Gene namesi
    Name:dxsUniRule annotationImported
    Ordered Locus Names:CD196_1067Imported
    OrganismiPeptoclostridium difficile (strain CD196) (Clostridium difficile)Imported
    Taxonomic identifieri645462 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
    ProteomesiUP000002068: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi645462.CD196_1067.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni115 – 1173Thiamine pyrophosphate bindingUniRule annotation
    Regioni147 – 1482Thiamine pyrophosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the transketolase family. DXPS subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1154.
    HOGENOMiHOG000012987.
    KOiK01662.
    OMAiNIAIMSP.
    OrthoDBiEOG6BKJ6P.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 3 hits.
    HAMAPiMF_00315. DXP_synth.
    InterProiIPR005477. Dxylulose-5-P_synthase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR020826. Transketolase_BS.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view]
    PfamiPF13292. DXP_synthase_N. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view]
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 3 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsiTIGR00204. dxs. 1 hit.
    PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
    PS00802. TRANSKETOLASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C9XNT4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYKYLDKVNS PKDIKNMSIE EMDLLAKDIR KFLVKSVSKT GGHLASNLGV    50
    VELTLALHKV FDSPKDKIVW DVGHQSYVHK IVTGRKDCFV SLRQFNGLSG 100
    FPKENESPHD IFDTGHSSTS ISIATGIACA RDIKKENYSV ISVIGDGSIT 150
    GGMALEALNQ LGYIDTNMIV ILNDNEMSID KNVGGMSKYL SSIIRNSTVE 200
    KMTDEVDKIL NVTQTGEILS KTAHRFKDKL MYSFSPQDCS FFDSLGIRYY 250
    GPIDGHNTKE LIDILRKAKH KKGPVLLHVI TKKGKGYRFA EEQPDKYHGV 300
    SKFDIKTGVT SAKVKSMSIS VGEKLVDMAN NNEDIVAITA AMPSGTGLNL 350
    FESAYPKRYY DVGIAEQHAT GFAAGLAKNG MKPYFAVYSS FLQRAYDQVI 400
    HDVCITKKPV TFLIDRAGLV GNDGETHHGM FDLSYLNSIP NIVVMAPKDT 450
    REMELMMDLS LKLDCPLAIR YPRGSSYYLD KGEYGEIVLG KYEVLDDGQD 500
    TVILCIGSMV KHALEAKEIL SREGINPTIV NARFLKPIDE GMLKALLKNH 550
    KNVVTIEDNI VTGGFGSRIN KFIIDNEYNV NILNIAIPEE FVKHGNIDEL 600
    YDFVGLSPKS IADKIRKLVI E 621
    Length:621
    Mass (Da):68,970
    Last modified:November 24, 2009 - v1
    Checksum:iB99CF096BFC9762F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN538970 Genomic DNA. Translation: CBA62029.1.
    RefSeqiYP_003214098.1. NC_013315.1.

    Genome annotation databases

    EnsemblBacteriaiCBA62029; CBA62029; CD196_1067.
    GeneIDi8463984.
    KEGGicdc:CD196_1067.
    PATRICi19448384. VBICloDif125228_1108.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN538970 Genomic DNA. Translation: CBA62029.1 .
    RefSeqi YP_003214098.1. NC_013315.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 645462.CD196_1067.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBA62029 ; CBA62029 ; CD196_1067 .
    GeneIDi 8463984.
    KEGGi cdc:CD196_1067.
    PATRICi 19448384. VBICloDif125228_1108.

    Phylogenomic databases

    eggNOGi COG1154.
    HOGENOMi HOG000012987.
    KOi K01662.
    OMAi NIAIMSP.
    OrthoDBi EOG6BKJ6P.

    Enzyme and pathway databases

    UniPathwayi UPA00064 ; UER00091 .
    BioCyci CDIF645462:GJED-1153-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 3 hits.
    HAMAPi MF_00315. DXP_synth.
    InterProi IPR005477. Dxylulose-5-P_synthase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR020826. Transketolase_BS.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view ]
    Pfami PF13292. DXP_synthase_N. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 3 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsi TIGR00204. dxs. 1 hit.
    PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
    PS00802. TRANSKETOLASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium."
      Stabler R.A., He M., Dawson L., Martin M., Valiente E., Corton C., Lawley T.D., Sebaihia M., Quail M.A., Rose G., Gerding D.N., Gibert M., Popoff M.R., Parkhill J., Dougan G., Wren B.W.
      Genome Biol. 10:R102.1-R102.15(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CD196Imported.

    Entry informationi

    Entry nameiC9XNT4_PEPDC
    AccessioniPrimary (citable) accession number: C9XNT4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 24, 2009
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3