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C9XNT4

- C9XNT4_PEPDC

UniProt

C9XNT4 - C9XNT4_PEPDC

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Protein

1-deoxy-D-xylulose-5-phosphate synthase

Gene
dxs, CD196_1067
Organism
Peptoclostridium difficile (strain CD196) (Clostridium difficile)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotationSAAS annotations

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotationSAAS annotations
Binds 1 thiamine pyrophosphate per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741Thiamine pyrophosphate By similarityUniRule annotation
Metal bindingi146 – 1461Magnesium By similarityUniRule annotation
Metal bindingi175 – 1751Magnesium By similarityUniRule annotation
Binding sitei175 – 1751Thiamine pyrophosphate By similarityUniRule annotation
Binding sitei287 – 2871Thiamine pyrophosphate By similarityUniRule annotation
Binding sitei366 – 3661Thiamine pyrophosphate By similarityUniRule annotation

GO - Molecular functioni

  1. 1-deoxy-D-xylulose-5-phosphate synthase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 1-deoxy-D-xylulose 5-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
  3. thiamine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotations

Keywords - Biological processi

Isoprene biosynthesisUniRule annotationSAAS annotations, Thiamine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Thiamine pyrophosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCDIF645462:GJED-1153-MONOMER.
UniPathwayiUPA00064; UER00091.

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose-5-phosphate synthaseUniRule annotation (EC:2.2.1.7UniRule annotation)
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Gene namesi
Name:dxsUniRule annotationImported
Ordered Locus Names:CD196_1067Imported
OrganismiPeptoclostridium difficile (strain CD196) (Clostridium difficile)Imported
Taxonomic identifieri645462 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
ProteomesiUP000002068: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi645462.CD196_1067.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 1173Thiamine pyrophosphate binding By similarityUniRule annotation
Regioni147 – 1482Thiamine pyrophosphate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the transketolase family. DXPS subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1154.
HOGENOMiHOG000012987.
KOiK01662.
OMAiNIAIMSP.
OrthoDBiEOG6BKJ6P.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 3 hits.
HAMAPiMF_00315. DXP_synth.
InterProiIPR005477. Dxylulose-5-P_synthase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF13292. DXP_synthase_N. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 3 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00204. dxs. 1 hit.
PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9XNT4-1 [UniParc]FASTAAdd to Basket

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MYKYLDKVNS PKDIKNMSIE EMDLLAKDIR KFLVKSVSKT GGHLASNLGV    50
VELTLALHKV FDSPKDKIVW DVGHQSYVHK IVTGRKDCFV SLRQFNGLSG 100
FPKENESPHD IFDTGHSSTS ISIATGIACA RDIKKENYSV ISVIGDGSIT 150
GGMALEALNQ LGYIDTNMIV ILNDNEMSID KNVGGMSKYL SSIIRNSTVE 200
KMTDEVDKIL NVTQTGEILS KTAHRFKDKL MYSFSPQDCS FFDSLGIRYY 250
GPIDGHNTKE LIDILRKAKH KKGPVLLHVI TKKGKGYRFA EEQPDKYHGV 300
SKFDIKTGVT SAKVKSMSIS VGEKLVDMAN NNEDIVAITA AMPSGTGLNL 350
FESAYPKRYY DVGIAEQHAT GFAAGLAKNG MKPYFAVYSS FLQRAYDQVI 400
HDVCITKKPV TFLIDRAGLV GNDGETHHGM FDLSYLNSIP NIVVMAPKDT 450
REMELMMDLS LKLDCPLAIR YPRGSSYYLD KGEYGEIVLG KYEVLDDGQD 500
TVILCIGSMV KHALEAKEIL SREGINPTIV NARFLKPIDE GMLKALLKNH 550
KNVVTIEDNI VTGGFGSRIN KFIIDNEYNV NILNIAIPEE FVKHGNIDEL 600
YDFVGLSPKS IADKIRKLVI E 621
Length:621
Mass (Da):68,970
Last modified:November 24, 2009 - v1
Checksum:iB99CF096BFC9762F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN538970 Genomic DNA. Translation: CBA62029.1.
RefSeqiYP_003214098.1. NC_013315.1.

Genome annotation databases

EnsemblBacteriaiCBA62029; CBA62029; CD196_1067.
GeneIDi8463984.
KEGGicdc:CD196_1067.
PATRICi19448384. VBICloDif125228_1108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN538970 Genomic DNA. Translation: CBA62029.1 .
RefSeqi YP_003214098.1. NC_013315.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 645462.CD196_1067.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBA62029 ; CBA62029 ; CD196_1067 .
GeneIDi 8463984.
KEGGi cdc:CD196_1067.
PATRICi 19448384. VBICloDif125228_1108.

Phylogenomic databases

eggNOGi COG1154.
HOGENOMi HOG000012987.
KOi K01662.
OMAi NIAIMSP.
OrthoDBi EOG6BKJ6P.

Enzyme and pathway databases

UniPathwayi UPA00064 ; UER00091 .
BioCyci CDIF645462:GJED-1153-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 3 hits.
HAMAPi MF_00315. DXP_synth.
InterProi IPR005477. Dxylulose-5-P_synthase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF13292. DXP_synthase_N. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view ]
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 3 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00204. dxs. 1 hit.
PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium."
    Stabler R.A., He M., Dawson L., Martin M., Valiente E., Corton C., Lawley T.D., Sebaihia M., Quail M.A., Rose G., Gerding D.N., Gibert M., Popoff M.R., Parkhill J., Dougan G., Wren B.W.
    Genome Biol. 10:R102.1-R102.15(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CD196Imported.

Entry informationi

Entry nameiC9XNT4_PEPDC
AccessioniPrimary (citable) accession number: C9XNT4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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