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Protein

Aspartate carbamoyltransferase regulatory chain

Gene

pyrI

Organism
Salmonella typhimurium (strain D23580)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in allosteric regulation of aspartate carbamoyltransferase.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi109 – 1091ZincUniRule annotation
Metal bindingi114 – 1141ZincUniRule annotation
Metal bindingi138 – 1381ZincUniRule annotation
Metal bindingi141 – 1411ZincUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. pyrimidine nucleotide biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciSENT568708:GJDP-4491-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferase regulatory chainUniRule annotation
Gene namesi
Name:pyrIUniRule annotation
Ordered Locus Names:STMMW_44041Imported
OrganismiSalmonella typhimurium (strain D23580)Imported
Taxonomic identifieri568708 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000002622: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. aspartate carbamoyltransferase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiC9XE68.

Interactioni

Subunit structurei

Contains catalytic and regulatory chains.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC9XE68.
SMRiC9XE68. Positions 1-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PyrI family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000113530.

Family and domain databases

Gene3Di2.30.30.20. 1 hit.
3.30.70.140. 1 hit.
HAMAPiMF_00002. Asp_carb_tr_reg.
InterProiIPR020545. Asp_carbamoyltransf_reg_N.
IPR002801. Asp_carbamoylTrfase_reg.
IPR020542. Asp_carbamoyltrfase_reg_C.
[Graphical view]
PfamiPF01948. PyrI. 1 hit.
PF02748. PyrI_C. 1 hit.
[Graphical view]
ProDomiPD006194. Asp_carbamoylTrfase_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54893. SSF54893. 1 hit.
SSF57825. SSF57825. 1 hit.
TIGRFAMsiTIGR00240. ATCase_reg. 1 hit.

Sequencei

Sequence statusi: Complete.

C9XE68-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHDNKLQVE AIKCGTVIDH IPAQVGFKLL SLFKLTETDQ RITIGLNLPS
60 70 80 90 100
GEMGRKDLIK IENTFLTEEQ VNQLALYAPQ ATVNRIDNYD VVGKSRPSLP
110 120 130 140 150
ERINNVLVCP NSNCISHAEP VSSSFAVKKR ANDIALKCKY CEKEFSHYVV

LAN
Length:153
Mass (Da):17,087
Last modified:November 24, 2009 - v1
Checksum:i5C5730A07D45FD6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN424405 Genomic DNA. Translation: CBG27414.1.
RefSeqiYP_005235400.1. NC_016854.1.

Genome annotation databases

EnsemblBacteriaiCBG27414; CBG27414; STMMW_44041.
PATRICi36730695. VBISalEnt111430_4709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN424405 Genomic DNA. Translation: CBG27414.1.
RefSeqiYP_005235400.1. NC_016854.1.

3D structure databases

ProteinModelPortaliC9XE68.
SMRiC9XE68. Positions 1-153.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiC9XE68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBG27414; CBG27414; STMMW_44041.
PATRICi36730695. VBISalEnt111430_4709.

Phylogenomic databases

HOGENOMiHOG000113530.

Enzyme and pathway databases

BioCyciSENT568708:GJDP-4491-MONOMER.

Family and domain databases

Gene3Di2.30.30.20. 1 hit.
3.30.70.140. 1 hit.
HAMAPiMF_00002. Asp_carb_tr_reg.
InterProiIPR020545. Asp_carbamoyltransf_reg_N.
IPR002801. Asp_carbamoylTrfase_reg.
IPR020542. Asp_carbamoyltrfase_reg_C.
[Graphical view]
PfamiPF01948. PyrI. 1 hit.
PF02748. PyrI_C. 1 hit.
[Graphical view]
ProDomiPD006194. Asp_carbamoylTrfase_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54893. SSF54893. 1 hit.
SSF57825. SSF57825. 1 hit.
TIGRFAMsiTIGR00240. ATCase_reg. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Epidemic multiple drug resistant Salmonella typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype."
    Kingsley R.A., Msefula C.L., Thomson N.R., Kariuki S., Holt K.E., Gordon M.A., Harris D., Clarke L., Whitehead S., Sangal V., Marsh K., Achtman M., Molyneux M.E., Cormican M., Parkhill J., Maclennan C.A., Heyderman R.S., Dougan G.
    Genome Res. 19:2279-2287(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D23580Imported.

Entry informationi

Entry nameiC9XE68_SALTD
AccessioniPrimary (citable) accession number: C9XE68
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: January 7, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.