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Protein

Venom serine carboxypeptidase

Gene
N/A
Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei202By similarity1
Active sitei387By similarity1
Active sitei444By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERiapime-vcp. Carboxypeptidase_S10.
MEROPSiS10.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Venom serine carboxypeptidase (EC:3.4.16.-)
Alternative name(s):
Allergen: Api m 9
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis
Proteomesi
  • UP000005203 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.By similarity

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei6189. Api m 9.
6190. Api m 9.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500052521919 – 467Venom serine carboxypeptidaseAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi304N-linked (GlcNAc...)Sequence analysis1
Glycosylationi322N-linked (GlcNAc...)Sequence analysis1
Glycosylationi344N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiC9WMM5.

Expressioni

Tissue specificityi

Expressed by the venom duct.

Interactioni

Protein-protein interaction databases

STRINGi7460.GB14710-PA.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
KOiK09645.
PhylomeDBiC9WMM5.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C9WMM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLVLLQFL FFISFARGFT NVYPKPKYCP LLHEEDAGIP LFLTPLIENG
60 70 80 90 100
KIDEARNKAV IQHKEVEAIS SYAGFLTVNK KYNSNMFFWF FPALHDPKTA
110 120 130 140 150
PVVLWLQGGP GATSMYGLFL ENGPFIVTKN KTLKMREYSW NKCHNLLYID
160 170 180 190 200
NPVGTGFSFT EDERGYATNE THVGRDVHTA LVQFFELFPE LQTNDFYVTG
210 220 230 240 250
ESYGGKYVPA VSHAIKDYNI KAKIKINLKG LAIGNGLTDP VNQLDYGDYL
260 270 280 290 300
YQLGLLDANG RNLFQKYEEQ GKNLIKQEKW LEAFDLFDEL LDGDITQQPS
310 320 330 340 350
LYKNLTGFDY YFNYLHEKDP SNDSDYMVEW LQRADVRKAI HVGNRTFIPE
360 370 380 390 400
SKKVEKYMKA DVMQSLAVLI ADLTQHYRVL IYNGQLDIIV AYPLTENYLQ
410 420 430 440 450
KLKWPGAEKY KTAQRKVWFV GNELAGYSKT VDSLTEVLVR NAGHMVPLDQ
460
PKWALDLITR FTHNKGF
Length:467
Mass (Da):53,702
Last modified:November 24, 2009 - v1
Checksum:i3482EB0FAF6BB466
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ765738 mRNA. Translation: ACN71203.1.
RefSeqiNP_001152775.1. NM_001159303.1.
UniGeneiAme.5189.

Genome annotation databases

GeneIDi410451.
KEGGiame:410451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ765738 mRNA. Translation: ACN71203.1.
RefSeqiNP_001152775.1. NM_001159303.1.
UniGeneiAme.5189.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7460.GB14710-PA.

Protein family/group databases

Allergomei6189. Api m 9.
6190. Api m 9.0101.
ESTHERiapime-vcp. Carboxypeptidase_S10.
MEROPSiS10.003.

Proteomic databases

PaxDbiC9WMM5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi410451.
KEGGiame:410451.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
KOiK09645.
PhylomeDBiC9WMM5.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVCP_APIME
AccessioniPrimary (citable) accession number: C9WMM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 24, 2009
Last modified: March 16, 2016
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.