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C9TXE7 (C9TXE7_BRUPB) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AEK54733.1
Ordered Locus Names:BPI_I1480 EMBL AEK54733.1
ORF Names:BAHG_01690 EMBL EEY00761.1
OrganismBrucella pinnipedialis (strain NCTC 12890 / BCCN 94-73 / B2/94) [Complete proteome] [HAMAP] EMBL EEY00761.1
Taxonomic identifier520461 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. SAAS SAAS011095 HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. SAAS SAAS011095 HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. SAAS SAAS011095 HAMAP-Rule MF_00047

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. SAAS SAAS011095 HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity SAAS SAAS011095 HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain102 – 302201ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding128 – 18356ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2521Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2691Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2691Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2711Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C9TXE7 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 633111E4CB6596F8

FASTA30833,394
        10         20         30         40         50         60 
MTGKHVAVLM GGFSSERSVS LSSGVACATT LEECGYRVTR IDVDRNVASI LVELKPDVVF 

        70         80         90        100        110        120 
NALHGPFGED GAIQGVLEYL QIPYTHSGVL ASALAMDKDR AKKVAAAAGV VVAPSRLMNR 

       130        140        150        160        170        180 
FDIGSQHPMK PPYVVKPVRE GSSFGVVIVK EDQPHPPQVI GSADWKYGDE VMVEGYIAGR 

       190        200        210        220        230        240 
ELTCAVMGDR AMDVCEIIPV GYQFYDYDSK YVAGASTHVC PAKILPNIYQ KIQTMALTAH 

       250        260        270        280        290        300 
RAIGCRGVSR SDFRFDDRFS EEGEVVWLEI NTQPGMTPTS LVPDIAKAAG ISFAELLSWM 


VEDASCLR 

« Hide

References

« Hide 'large scale' references
[1]"The Genome Sequence of Brucella pinnipedialis B2/94."
The Broad Institute Genome Sequencing Platform
Ward D., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C. expand/collapse author list , Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Whatmore A.M., Perrett L.L., O'Callaghan D., Nusbaum C., Galagan J., Birren B.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: B2/94 EMBL EEY00761.1.
[2]Zygmunt M., Clockaert A.
Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: B2/94 EMBL AEK54733.1.
[3]"The genome sequence of Brucella pinnipedialis B2/94 sheds light on the evolutionary history of the genus Brucella."
Audic S., Lescot M., Claverie J.M., Cloeckaert A., Zygmunt M.S.
BMC Evol. Biol. 11:200-200(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B2/94 EMBL AEK54733.1 and NCTC 12890 / BCCN 94-73 / B2/94.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002078 Genomic DNA. Translation: AEK54733.1.
DS999848 Genomic DNA. Translation: EEY00761.1.
RefSeqYP_004756501.1. NC_015857.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEK54733; AEK54733; BPI_I1480.
EEY00761; EEY00761; BAHG_01690.
GeneID10997957.
KEGGbpp:BPI_I1480.
PATRIC24252781. VBIBruPin17457_1509.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycBPIN520461:GJF0-1478-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC9TXE7_BRUPB
AccessionPrimary (citable) accession number: C9TXE7
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: July 9, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)