C9TVV8 (C9TVV8_BRUPB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydrolipoyl dehydrogenase RuleBase RU003692
EC=1.8.1.4 RuleBase RU003692

Gene names

Name:	lpdA-1 EMBL AEK54442.1
ORF Names:	BAHG_01410 EMBL EEY00481.1, BPI_I1173 EMBL AEK54442.1

Organism

Brucella pinnipedialis (strain NCTC 12890 / BCCN 94-73 / B2/94) [Complete proteome] [HAMAP] EMBL EEY00481.1

Taxonomic identifier

520461 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella pinnipedialis

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH. RuleBase RU003692
Cofactor	Binds 1 FAD per subunit By similarity. RuleBase RU003692
Miscellaneous	The active site is a redox-active disulfide bond By similarity. RuleBase RU003692
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. RuleBase RU003691

Ontologies

Keywords
Domain	Redox-active center RuleBase RU003691
Ligand	FAD RuleBase RU003691 Flavoprotein RuleBase RU003691 NAD RuleBase RU003692
Molecular function	Oxidoreductase RuleBase RU003691 EMBL AEK54442.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	dihydrolipoyl dehydrogenase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C9TVV8 [UniParc]. Last modified November 24, 2009. Version 1. Checksum: C10FED445D0BA0AA	FASTA	487	51,736
	10 20 30 40 50 60 MADIYDVIVI GSGPGGYVTA IRAAQLGLKT AIVEREHLGG ICLNWGCIPT KALLRSAEIL 70 80 90 100 110 120 HFGEHAKDYG LKLDGTITPD VKAVVQRSRG VSARLNGGVA FLMKKNKIDV IWGEAKLVKA 130 140 150 160 170 180 ASGSNPAEIS VGKTSKQPMQ PQNPVPKGVL GEGSYKAKHI IVATGARPRA LPGIEPDGKL 190 200 210 220 230 240 IWTYFEAMVP QALPKSMLVM GSGAIGIEFA SFYHDMGVDV TVVEVMSQIM PVEDAEISAI 250 260 270 280 290 300 ARKQLEKRGL KIITDAKVAK VEKGANSVTA HVETKDGKTQ TLTVDRMISA VGVQGNIENL 310 320 330 340 350 360 GLEALGVKTD RGCIVIDGYG KTNVAGIYAI GDVAGPPMLA HKAEHEGVIC VEKIAGLPNV 370 380 390 400 410 420 HPLDKGKIPG CTYCNPQVAS VGLTEAKAKE QGYDIRVGRY SFSANGKAIA LGEDQGLVKT 430 440 450 460 470 480 IFDRKTGQLL GAHMVGAEVT ELIQGFVIAM NLETTEEELM HSVFPHPTLS ETMKESVLDA YGRVLNA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Genome Sequence of Brucella pinnipedialis B2/94." The Broad Institute Genome Sequencing Platform Ward D., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C. , Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Whatmore A.M., Perrett L.L., O'Callaghan D., Nusbaum C., Galagan J., Birren B. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: B2/94 EMBL EEY00481.1.
[2]	Zygmunt M., Clockaert A. Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: B2/94 EMBL AEK54442.1.
[3]	"The genome sequence of Brucella pinnipedialis B2/94 sheds light on the evolutionary history of the genus Brucella." Audic S., Lescot M., Claverie J.M., Cloeckaert A., Zygmunt M.S. BMC Evol. Biol. 11:200-200(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B2/94 EMBL AEK54442.1 and NCTC 12890 / BCCN 94-73 / B2/94.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002078 Genomic DNA. Translation: AEK54442.1. DS999848 Genomic DNA. Translation: EEY00481.1.
RefSeq	YP_004756210.1. NC_015857.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEK54442; AEK54442; BPI_I1173. EEY00481; EEY00481; BAHG_01410.
GeneID	10997650.
KEGG	bpp:BPI_I1173.
PATRIC	24252161. VBIBruPin17457_1206.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00382.
Enzyme and pathway databases
BioCyc	BPIN520461:GJF0-1171-MONOMER.
Family and domain databases
Gene3D	3.30.390.30. 1 hit.
InterPro	IPR016156. FAD/NAD-linked_Rdtase_dimer. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR006258. Lipoamide_DH. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR012999. Pyr_OxRdtase_I_AS. IPR001327. Pyr_OxRdtase_NAD-bd_dom. [Graphical view]
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR.
SUPFAM	SSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
TIGRFAMs	TIGR01350. lipoamide_DH. 1 hit.
PROSITE	PS00076. PYRIDINE_REDOX_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C9TVV8_BRUPB

Accession

Primary (citable) accession number: C9TVV8

Entry history

Integrated into UniProtKB/TrEMBL:	November 24, 2009
Last sequence update:	November 24, 2009
Last modified:	May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)