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C9TTT1

- C9TTT1_BRUPB

UniProt

C9TTT1 - C9TTT1_BRUPB

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Protein
1-deoxy-D-xylulose-5-phosphate synthase
Gene
dxs, BPI_I466, BAHG_00761
Organism
Brucella pinnipedialis (strain NCTC 12890 / BCCN 94-73 / B2/94)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotationSAAS annotations

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotationSAAS annotations
Binds 1 thiamine pyrophosphate per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 781Thiamine pyrophosphate By similarityUniRule annotation
Metal bindingi150 – 1501Magnesium By similarityUniRule annotation
Metal bindingi179 – 1791Magnesium By similarityUniRule annotation
Binding sitei179 – 1791Thiamine pyrophosphate By similarityUniRule annotation
Binding sitei288 – 2881Thiamine pyrophosphate By similarityUniRule annotation
Binding sitei370 – 3701Thiamine pyrophosphate By similarityUniRule annotation

GO - Molecular functioni

  1. 1-deoxy-D-xylulose-5-phosphate synthase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 1-deoxy-D-xylulose 5-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
  3. thiamine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotations

Keywords - Biological processi

Isoprene biosynthesisUniRule annotationSAAS annotations, Thiamine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Thiamine pyrophosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBPIN520461:GJF0-465-MONOMER.
UniPathwayiUPA00064; UER00091.

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose-5-phosphate synthaseUniRule annotation (EC:2.2.1.7UniRule annotation)
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Gene namesi
Name:dxsUniRule annotationImported
Ordered Locus Names:BPI_I466Imported
ORF Names:BAHG_00761Imported
OrganismiBrucella pinnipedialis (strain NCTC 12890 / BCCN 94-73 / B2/94)Imported
Taxonomic identifieri520461 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000010095: Chromosome 1

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni119 – 1213Thiamine pyrophosphate binding By similarityUniRule annotation
Regioni151 – 1522Thiamine pyrophosphate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the transketolase family. DXPS subfamily.UniRule annotation

Phylogenomic databases

KOiK01662.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 3 hits.
HAMAPiMF_00315. DXP_synth.
InterProiIPR005477. Dxylulose-5-P_synthase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF13292. DXP_synthase_N. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 3 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00204. dxs. 1 hit.
PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9TTT1-1 [UniParc]FASTAAdd to Basket

« Hide

MSRPSTPLLD KAPTPDRLRA LPEQDLPQLA EELRTELIDA VSTTGGHLGA    50
GLGVVELTVA LHHVFNTPYD RIIWDVGHQA YPHKILTGRR DRIRTLRQAG 100
GLSGFTKRAE SEYDPFGAAH SSTSISAGLG MAVASELSGE KRNVIAVIGD 150
GSMSAGMAYE AMNNAGALDA RLIVILNDND MSIAPPTGAM SAYLARLVSG 200
RTYRSVREAA KQVAQKLPKF LQDKARKSEE YARAFFTGGT LFEELGFYYV 250
GPIDGHNLDH LLPVLKNVRD TQKGPVLIHV VTQKGKGYAP AEAAADKYHG 300
VNEFDVITGK QAKPPANAPS YTKIFGTSLI EEARHDDKIV AVTAAMPTGT 350
GLDLFGEAFP KRVFDVGIAE QHAVTFAAGL ASEGYKPFCA IYSTFLQRGY 400
DQVVHDVSIQ NLPVRFPIDR AGLVGADGPT HAGSFDTGFL AALPGFVVMA 450
ASDEAELRHM VRTAAEYDEG PISFRYPRGD GVGVDLPERG SVLEIGKGRI 500
VREGTKVALL SFGTRLQECL AAAEELGAAG LSTTVADARF AKPLDHDLIR 550
RLAREHEVLV MVEEGAVGGF GSHVLQFLAT DGLLDRGLKV RALTLPDIYQ 600
DHGKPDAMYA EAGLDRTGIV RTVFAALHRD ELGHEALPTP FRA 643
Length:643
Mass (Da):69,153
Last modified:November 24, 2009 - v1
Checksum:i4948F8DD11A59F65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002078 Genomic DNA. Translation: AEK53773.1.
DS999848 Genomic DNA. Translation: EEX99831.1.
RefSeqiYP_004755541.1. NC_015857.1.

Genome annotation databases

EnsemblBacteriaiAEK53773; AEK53773; BPI_I466.
EEX99831; EEX99831; BAHG_00761.
GeneIDi10996945.
KEGGibpp:BPI_I466.
PATRICi24250790. VBIBruPin17457_0401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002078 Genomic DNA. Translation: AEK53773.1 .
DS999848 Genomic DNA. Translation: EEX99831.1 .
RefSeqi YP_004755541.1. NC_015857.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEK53773 ; AEK53773 ; BPI_I466 .
EEX99831 ; EEX99831 ; BAHG_00761 .
GeneIDi 10996945.
KEGGi bpp:BPI_I466.
PATRICi 24250790. VBIBruPin17457_0401.

Phylogenomic databases

KOi K01662.

Enzyme and pathway databases

UniPathwayi UPA00064 ; UER00091 .
BioCyci BPIN520461:GJF0-465-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 3 hits.
HAMAPi MF_00315. DXP_synth.
InterProi IPR005477. Dxylulose-5-P_synthase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF13292. DXP_synthase_N. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view ]
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 3 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00204. dxs. 1 hit.
PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B2/94Imported.
  2. Zygmunt M., Clockaert A.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B2/94Imported.
  3. "The genome sequence of Brucella pinnipedialis B2/94 sheds light on the evolutionary history of the genus Brucella."
    Audic S., Lescot M., Claverie J.M., Cloeckaert A., Zygmunt M.S.
    BMC Evol. Biol. 11:200-200(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B2/94Imported and NCTC 12890 / BCCN 94-73 / B2/94.

Entry informationi

Entry nameiC9TTT1_BRUPB
AccessioniPrimary (citable) accession number: C9TTT1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi