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C9SV08

- IF6_VERA1

UniProt

C9SV08 - IF6_VERA1

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Protein

Eukaryotic translation initiation factor 6

Gene
TIF6, VDBG_08733
Organism
Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export By similarity.UniRule annotation

GO - Molecular functioni

  1. ribosomal large subunit binding Source: UniProtKB-HAMAP
  2. ribosome binding Source: InterPro
  3. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. mature ribosome assembly Source: UniProtKB-HAMAP
  2. ribosomal large subunit biogenesis Source: UniProtKB-HAMAP
  3. ribosomal subunit export from nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6
Short name:
eIF-6
Gene namesi
Name:TIF6
ORF Names:VDBG_08733
OrganismiVerticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Taxonomic identifieri526221 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesPlectosphaerellaceaemitosporic PlectosphaerellaceaeVerticillium
ProteomesiUP000008698: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity. Nucleusnucleolus By similarity
Note: Shuttles between cytoplasm and nucleus/nucleolus By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Eukaryotic translation initiation factor 6UniRule annotationPRO_0000402112Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741Phosphoserine; by CK1 By similarity
Modified residuei175 – 1751Phosphoserine; by CK1 By similarity

Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 promotes nuclear export By similarity.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit By similarity.

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.

Phylogenomic databases

KOiK03264.
OrthoDBiEOG7TTQKB.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

C9SV08-1 [UniParc]FASTAAdd to Basket

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MAVRAQFENS NEVGVFATLT NSYALTAIGA SENFYSVFEA ELQDVIPICR    50
TTIAGSRIIG RMTAGNRKGL LVPTNTTDQE LQHLRNSLPD AIRIQRIEER 100
LSALGNVIVT NDHIALVHPD IERETEEIIA DVLGVEVFRQ TIADNVLVGS 150
YMSLSNQGGL VHPKTSIQDQ DELSSLLQVP LVAGSVNRGS NVVGAGMVVN 200
DWMAVTGLDT TATELSVIES VFRLGEGLGP SNINTGMKDT MVESFY 246
Length:246
Mass (Da):26,577
Last modified:November 30, 2010 - v2
Checksum:i4B5A0A5928125123
GO

Sequence cautioni

The sequence EEY22623.1 differs from that shown. Reason: Frameshift at position 163.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS985226 Genomic DNA. Translation: EEY22623.1. Frameshift.
RefSeqiXP_003000937.1. XM_003000891.1.

Genome annotation databases

GeneIDi9534325.
KEGGival:VDBG_08733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS985226 Genomic DNA. Translation: EEY22623.1 . Frameshift.
RefSeqi XP_003000937.1. XM_003000891.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9534325.
KEGGi val:VDBG_08733.

Phylogenomic databases

KOi K03264.
OrthoDBi EOG7TTQKB.

Family and domain databases

HAMAPi MF_00032. eIF_6.
InterProi IPR002769. eIF6.
[Graphical view ]
PANTHERi PTHR10784. PTHR10784. 1 hit.
Pfami PF01912. eIF-6. 1 hit.
[Graphical view ]
PIRSFi PIRSF006413. IF-6. 1 hit.
SMARTi SM00654. eIF6. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00323. eIF-6. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VaMs.102 / ATCC MYA-4576 / FGSC 10136.

Entry informationi

Entry nameiIF6_VERA1
AccessioniPrimary (citable) accession number: C9SV08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 11, 2014
This is version 24 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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