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C9SV08 (IF6_VERA1) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export By similarity. HAMAP-Rule MF_03132

Subunit structure

Monomer. Associates with the 60S ribosomal subunit By similarity.

Subcellular location

Cytoplasm By similarity. Nucleusnucleolus By similarity. Note: Shuttles between cytoplasm and nucleus/nucleolus By similarity. HAMAP-Rule MF_03132

Post-translational modification

Phosphorylation at Ser-174 and Ser-175 promotes nuclear export By similarity. HAMAP-Rule MF_03132

Sequence similarities

Belongs to the eIF-6 family.

Sequence caution

The sequence EEY22623.1 differs from that shown. Reason: Frameshift at position 163.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Eukaryotic translation initiation factor 6 HAMAP-Rule MF_03132
PRO_0000402112

Amino acid modifications

Modified residue1741Phosphoserine; by CK1 By similarity
Modified residue1751Phosphoserine; by CK1 By similarity

Sequences

Sequence LengthMass (Da)Tools
C9SV08 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: 4B5A0A5928125123

FASTA24626,577
        10         20         30         40         50         60 
MAVRAQFENS NEVGVFATLT NSYALTAIGA SENFYSVFEA ELQDVIPICR TTIAGSRIIG 

        70         80         90        100        110        120 
RMTAGNRKGL LVPTNTTDQE LQHLRNSLPD AIRIQRIEER LSALGNVIVT NDHIALVHPD 

       130        140        150        160        170        180 
IERETEEIIA DVLGVEVFRQ TIADNVLVGS YMSLSNQGGL VHPKTSIQDQ DELSSLLQVP 

       190        200        210        220        230        240 
LVAGSVNRGS NVVGAGMVVN DWMAVTGLDT TATELSVIES VFRLGEGLGP SNINTGMKDT 


MVESFY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS985226 Genomic DNA. Translation: EEY22623.1. Frameshift.
RefSeqXP_003000937.1. XM_003000891.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9534325.
KEGGval:VDBG_08733.

Phylogenomic databases

KOK03264.
OrthoDBEOG7TTQKB.

Family and domain databases

HAMAPMF_00032. eIF_6.
InterProIPR002769. eIF6.
[Graphical view]
PANTHERPTHR10784. PTHR10784. 1 hit.
PfamPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFPIRSF006413. IF-6. 1 hit.
SMARTSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsTIGR00323. eIF-6. 1 hit.
ProtoNetSearch...

Entry information

Entry nameIF6_VERA1
AccessionPrimary (citable) accession number: C9SV08
Entry history
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 11, 2014
This is version 24 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries