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C9SV08

- IF6_VERA1

UniProt

C9SV08 - IF6_VERA1

Protein

Eukaryotic translation initiation factor 6

Gene

TIF6

Organism
Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.UniRule annotation

    GO - Molecular functioni

    1. ribosomal large subunit binding Source: UniProtKB-HAMAP
    2. ribosome binding Source: InterPro
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mature ribosome assembly Source: UniProtKB-HAMAP
    2. ribosomal large subunit biogenesis Source: UniProtKB-HAMAP
    3. ribosomal subunit export from nucleus Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis, Ribosome biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 6UniRule annotation
    Short name:
    eIF-6UniRule annotation
    Gene namesi
    Name:TIF6UniRule annotation
    ORF Names:VDBG_08733
    OrganismiVerticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
    Taxonomic identifieri526221 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesPlectosphaerellaceaemitosporic PlectosphaerellaceaeVerticillium
    ProteomesiUP000008698: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleusnucleolus UniRule annotation
    Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Eukaryotic translation initiation factor 6PRO_0000402112Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei174 – 1741Phosphoserine; by CK1UniRule annotation
    Modified residuei175 – 1751Phosphoserine; by CK1UniRule annotation

    Post-translational modificationi

    Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.UniRule annotation

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eIF-6 family.UniRule annotation

    Phylogenomic databases

    KOiK03264.
    OrthoDBiEOG7TTQKB.

    Family and domain databases

    HAMAPiMF_00032. eIF_6.
    InterProiIPR002769. eIF6.
    [Graphical view]
    PANTHERiPTHR10784. PTHR10784. 1 hit.
    PfamiPF01912. eIF-6. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006413. IF-6. 1 hit.
    SMARTiSM00654. eIF6. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00323. eIF-6. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C9SV08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVRAQFENS NEVGVFATLT NSYALTAIGA SENFYSVFEA ELQDVIPICR    50
    TTIAGSRIIG RMTAGNRKGL LVPTNTTDQE LQHLRNSLPD AIRIQRIEER 100
    LSALGNVIVT NDHIALVHPD IERETEEIIA DVLGVEVFRQ TIADNVLVGS 150
    YMSLSNQGGL VHPKTSIQDQ DELSSLLQVP LVAGSVNRGS NVVGAGMVVN 200
    DWMAVTGLDT TATELSVIES VFRLGEGLGP SNINTGMKDT MVESFY 246
    Length:246
    Mass (Da):26,577
    Last modified:November 30, 2010 - v2
    Checksum:i4B5A0A5928125123
    GO

    Sequence cautioni

    The sequence EEY22623.1 differs from that shown. Reason: Frameshift at position 163.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS985226 Genomic DNA. Translation: EEY22623.1. Frameshift.
    RefSeqiXP_003000937.1. XM_003000891.1.

    Genome annotation databases

    GeneIDi9534325.
    KEGGival:VDBG_08733.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS985226 Genomic DNA. Translation: EEY22623.1 . Frameshift.
    RefSeqi XP_003000937.1. XM_003000891.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9534325.
    KEGGi val:VDBG_08733.

    Phylogenomic databases

    KOi K03264.
    OrthoDBi EOG7TTQKB.

    Family and domain databases

    HAMAPi MF_00032. eIF_6.
    InterProi IPR002769. eIF6.
    [Graphical view ]
    PANTHERi PTHR10784. PTHR10784. 1 hit.
    Pfami PF01912. eIF-6. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006413. IF-6. 1 hit.
    SMARTi SM00654. eIF6. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00323. eIF-6. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VaMs.102 / ATCC MYA-4576 / FGSC 10136.

    Entry informationi

    Entry nameiIF6_VERA1
    AccessioniPrimary (citable) accession number: C9SV08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 30, 2010
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 25 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3