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C9SR45 (AMPP1_VERA1) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9
Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase
Gene names
Name:AMPP
ORF Names:VDBG_06957
OrganismVerticillium albo-atrum (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt) [Complete proteome]
Taxonomic identifier526221 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Glomerellales › Plectosphaerellaceae › mitosporic Plectosphaerellaceae › Verticillium ›

Protein attributes

Sequence length612 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.

Catalytic activity

Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Sequence similarities

Belongs to the peptidase M24B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 612612Probable Xaa-Pro aminopeptidase P
PRO_0000411814

Sites

Metal binding4091Manganese 2 By similarity
Metal binding4201Manganese 1 By similarity
Metal binding4201Manganese 2 By similarity
Metal binding5181Manganese 1 By similarity
Metal binding5321Manganese 1 By similarity
Metal binding5321Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
C9SR45 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: B391DC01B81B35CD

FASTA61267,404
        10         20         30         40         50         60 
MEKVDTSGRL SKLRELMRAH SIDVYVVPSE DSHSSEYIAA CDARREFISG FSGSAGCAVI 

        70         80         90        100        110        120 
TLDKAALATD GRYFNQASKQ LDHNWLLLKQ GLQDVPTWQD WSAEQSAGGK IVAVDPELIA 

       130        140        150        160        170        180 
AAAAKKLAAK IHKFGGSELV ALERNLVDVV WGKDRPDRPR NPVVILDTAF SGKNVETKLR 

       190        200        210        220        230        240 
DLRQELVKKD SLGMVVSMLD EVAWLLNLRG SDIPYNPVFF SYAVITLDTA TLFVDDTKLH 

       250        260        270        280        290        300 
PDSLEYLRKN GIVTKPYSCI FDDVKALTSS KGVQGREKRT LLSSKASWAL KRALGGDDLV 

       310        320        330        340        350        360 
EEVRSFIGDA KAVKNEAELA GMRACHIRDG IALIEYFAWL EDQLVAKRIV LDEVEAADKL 

       370        380        390        400        410        420 
EELRQKQENY VGLSFDTISS TGANAAVIHY KPERGSCPAI DPEAIYLCDS GAQYLDGTTD 

       430        440        450        460        470        480 
VTRTVHFGCP TAAEKLAYTL VLKGNIALDS AIFPKGTTGF ALDCLARQHL WREGLDYRHG 

       490        500        510        520        530        540 
TGHGVGSYLN VHEGPIGIGT RVQFAEVSLA SGNVVSIEPG FYEDGAFGIR IENLAIVREV 

       550        560        570        580        590        600 
QTQHSFGDKP YLGFEHVTMA PYCKNLIDIS ILTTAEKEWL NAHNTDIFNK TKDAFKDDAL 

       610 
TLAWLTRETQ PI

« Hide

References

[1]"Annotation of Verticillium albo-atrum VaMs.102."
The Broad Institute Genome Sequencing Platform
Ma L.-J.J., Klosterman S.J., Subbarao K., Dobinson K., Veronese P., Kang S., Gold S.E., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D., Hepburn T., Sykes S., Chen Z., Alvarado L., Kodira C.D., Lander E. expand/collapse author list , Galagan J., Nusbaum C., Birren B.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VaMs.102 / ATCC MYA-4576 / FGSC 10136.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DS985222 Genomic DNA. Translation: EEY20847.1.
RefSeqXP_003002386.1. XM_003002340.1.

3D structure databases

ProteinModelPortalC9SR45.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9527377.
KEGGval:VDBG_06957.

Phylogenomic databases

KOK01262.

Family and domain databases

Gene3D3.90.230.10. 1 hit.
InterProIPR000587. Creatinase.
IPR000994. Pept_M24_structural-domain.
IPR001131. Peptidase_M24B_aminopep-P_CS.
[Graphical view]
PfamPF01321. Creatinase_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
[Graphical view]
SUPFAMSSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITEPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPP1_VERA1
AccessionPrimary (citable) accession number: C9SR45
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: November 24, 2009
Last modified: March 6, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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