Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei726Charge relay systemBy similarity1
Active sitei803Charge relay systemBy similarity1
Active sitei836Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERivera1-dapb. DPP4N_Peptidase_S9.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:VDBG_05047
OrganismiVerticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Taxonomic identifieri526221 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesPlectosphaerellaceaeVerticillium
Proteomesi
  • UP000008698 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 98CytoplasmicSequence analysisAdd BLAST98
Transmembranei99 – 119Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini120 – 875VacuolarSequence analysisAdd BLAST756

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004121681 – 875Probable dipeptidyl-aminopeptidase BAdd BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi354N-linked (GlcNAc...)Sequence analysis1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1
Glycosylationi785N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi526221.XP_003005441.1.

Structurei

3D structure databases

ProteinModelPortaliC9SJ15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2100. Eukaryota.
COG1506. LUCA.
KOiK01282.
OrthoDBiEOG092C0PZJ.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

C9SJ15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPKPIQDT LDRRHSRESS ISSASTTSLV FDRLAEESEK NHDASSRPHP
60 70 80 90 100
SAARHAYTDD NSDAIKESDI NDPETGPFLG ASSETTPPRK GVDRKLKKVL
110 120 130 140 150
LIVGGFFVAA WIVSLVVFLT NKSYKHGSQI DHDPAATNRK SGKRVTLDQV
160 170 180 190 200
QSGFWRPTSH TFSWIPGPDG EDGLLLEQEA RGKHFLVVED VRSQGSADGE
210 220 230 240 250
AHPDAAESRT LIKDPWFYWG DQQHSILQTW PSKNQKKVLV ATQKQRNWRH
260 270 280 290 300
SFTALYWVFD VESQSAEPLD PAHPEERVQL ATWNAQSDAI VFTRSNNLFL
310 320 330 340 350
RKLADDKVTP ITTDGGPEYF YGIPDWVYEE EVFSGNSATW WSADGKHVAF
360 370 380 390 400
LRTNETEVPE YPIQYFVSRP SGAEPEVGEE NYPEVRQIKY PKVGSPNPVV
410 420 430 440 450
DLLFYDVEKG DVFTVDIDGD FPEKDKLINF VMWADGNVLV KTTNRVSDVL
460 470 480 490 500
QVNLIDIVAR TGKTVQHVDV AKIDGGWFEI SHVMYIPADP KNGRPHDGYV
510 520 530 540 550
DTVIHNDGDH LAYFTPMDNP KPVYITEGPG WEVDGSASAV DLKNNLVYFR
560 570 580 590 600
STKESSIQRH IYSVHLNGTD MKPFTDTTHE SYYDVSFSSG AGFGLLSYQG
610 620 630 640 650
PKVPWQKVVS TPSNPKSYER IIEENKDLTQ QAKKHELPVL EYGTIKVDDV
660 670 680 690 700
ELNYVERRPP HFDKNKKYPV LFQQYSGPGS QTVTKKFAVD FQSSDGGRRT
710 720 730 740 750
TRSPRRATGR PSATSTPTAF AIWGWSYGGF ATLKTLETDA GRTFRYGMAV
760 770 780 790 800
APVTDWRFYD SIYTERYMRT PDLNRNGYQQ TAISNTTALG ANERFLVMHG
810 820 830 840 850
VADDNVHMQN TLTLLDELDL AGVENYDVHV FPDSDHSIYF HNANRIVYDK
860 870
LSNWLINAFN GEWVKVNDAK PKIES
Length:875
Mass (Da):98,704
Last modified:November 24, 2009 - v1
Checksum:i6ED2051D22DBFEB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985218 Genomic DNA. Translation: EEY18938.1.
RefSeqiXP_003005441.1. XM_003005395.1.

Genome annotation databases

EnsemblFungiiEEY18938; EEY18938; VDBG_05047.
GeneIDi9532123.
KEGGival:VDBG_05047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985218 Genomic DNA. Translation: EEY18938.1.
RefSeqiXP_003005441.1. XM_003005395.1.

3D structure databases

ProteinModelPortaliC9SJ15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi526221.XP_003005441.1.

Protein family/group databases

ESTHERivera1-dapb. DPP4N_Peptidase_S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEY18938; EEY18938; VDBG_05047.
GeneIDi9532123.
KEGGival:VDBG_05047.

Phylogenomic databases

eggNOGiKOG2100. Eukaryota.
COG1506. LUCA.
KOiK01282.
OrthoDBiEOG092C0PZJ.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDAPB_VERA1
AccessioniPrimary (citable) accession number: C9SJ15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: November 24, 2009
Last modified: September 7, 2016
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.