C9SEV5 (AMPP3_VERA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase PEPP
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	PEPP
ORF Names:	VDBG_02807

Organism

Verticillium albo-atrum (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt) [Complete proteome]

Taxonomic identifier

526221 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Hypocreomycetidae › Glomerellales › Plectosphaerellaceae › mitosporic Plectosphaerellaceae › Verticillium › Verticillium albo-atrum

Protein attributes

Sequence length	563 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 563	563	Probable Xaa-Pro aminopeptidase PEPP		PRO_0000411892
Sites
	Metal binding	331	1	Manganese 2 By similarity
	Metal binding	342	1	Manganese 1 By similarity
	Metal binding	342	1	Manganese 2 By similarity
	Metal binding	491	1	Manganese 1 By similarity
	Metal binding	532	1	Manganese 1 By similarity
	Metal binding	532	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C9SEV5 [UniParc]. Last modified November 24, 2009. Version 1. Checksum: 0BACEA0C22BA0697	FASTA	563	60,027
	10 20 30 40 50 60 MASGDNVDYE AVMVDEFDAL NIEVRVSAGP SSSVPGAALS APRCPGMRAL PLKAPVMSTP 70 80 90 100 110 120 VPAAAPLPTP PAVDDGPSAV GVGNVPPAVD DVPSAVDDVV IQKETTKYSA KLHAAKVADE 130 140 150 160 170 180 LKASAGLVFL PGEPSRTYEY SDMGPAFSSN AATSSTSPAS TSLTPRKVLY NGRVPSIKDV 190 200 210 220 230 240 LAASDVDEVR HMQDLPAFLH AYAHQHDKAT VYLLDASQSH PALVDNARVH IDTAALRPAM 250 260 270 280 290 300 DEARVTKTAH EIALIREANA VSSAAHRAVM RHIRRFASER QVAALFTAEC TVRGAPTQAY 310 320 330 340 350 360 APIAGSGPNA ATLHYGANDE PLAGRHVLVL DAGCEVNCYA SDVTRTLPLG PTGHFTPEAR 370 380 390 400 410 420 HIYDLVERMQ EACVAAVAPG LLYYSLHLKA SAIALRGLLR LGILKGDEKA IWAAGTVAAF 430 440 450 460 470 480 FPHGLGHHIG LETHDVTGRD RLLLAAGERE PRAKRDAVSA EMLVGLAAAV ATGPPYRGKQ 490 500 510 520 530 540 MLRPGMVVTV EPGIYFNKDY IEGYFLREDK HRAFIDRDVL ARYYPVGGVR IEDCILVTDD 550 560 GYENLTKAPK GEDMLRIIRG EAQ

References

[1]

"Annotation of Verticillium albo-atrum VaMs.102." The Broad Institute Genome Sequencing Platform Ma L.-J.J., Klosterman S.J., Subbarao K., Dobinson K., Veronese P., Kang S., Gold S.E., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D., Hepburn T., Sykes S., Chen Z., Alvarado L., Kodira C.D., Lander E. , Galagan J., Nusbaum C., Birren B. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VaMs.102 / ATCC MYA-4576 / FGSC 10136.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS985216 Genomic DNA. Translation: EEY16698.1.
RefSeq	XP_003006668.1. XM_003006622.1.
3D structure databases
ProteinModelPortal	C9SEV5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9532810.
KEGG	val:VDBG_02807.
Phylogenomic databases
KO	K14213.
Family and domain databases
Gene3D	3.90.230.10. 2 hits.
InterPro	IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP3_VERA1

Accession

Primary (citable) accession number: C9SEV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	November 24, 2009
Last modified:	March 6, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program