C9SDK8 (AMPP2_VERA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase VDBG_02538
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

VDBG_02538

Organism

Verticillium albo-atrum (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt) [Complete proteome]

Taxonomic identifier

526221 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Hypocreomycetidae › Glomerellales › Plectosphaerellaceae › mitosporic Plectosphaerellaceae › Verticillium › Verticillium albo-atrum

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 460	460	Probable Xaa-Pro aminopeptidase VDBG_02538		PRO_0000411857
Sites
	Metal binding	256	1	Manganese 2 By similarity
	Metal binding	267	1	Manganese 1 By similarity
	Metal binding	267	1	Manganese 2 By similarity
	Metal binding	390	1	Manganese 1 By similarity
	Metal binding	430	1	Manganese 1 By similarity
	Metal binding	430	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C9SDK8 [UniParc]. Last modified November 24, 2009. Version 1. Checksum: 61674BB07A92EB65	FASTA	460	51,296
	10 20 30 40 50 60 MSDYETILKG KYPAKDHAKR VADHIRSKVP GANGILYLEG RHTKLEEDSD HPEPFRQRRY 70 80 90 100 110 120 FFYLTGCILA DCHYIFDLKT SQSTLFIPPV DPEDVIWSGM PMTAEEAKEK YDIDNVLYTN 130 140 150 160 170 180 EVNAELARLG KGSGSTAFAI ANQVLDTVSF IGFEDKNFDV LKGAIEECRV VKDDYEVALT 190 200 210 220 230 240 RKANAISTTA HHAVMKAVNT AKNEQELEAI FLERCFAHGA KNQAYHAIHA AGRAAATLHY 250 260 270 280 290 300 VHNSAPLDGK LNVLLDGGAE WDCYASDITR TFPISGKFSK ESRAIYDIVL KMQLESIKVL 310 320 330 340 350 360 KEGILWDDVH ELAHKIAIEG LLDLGILKGE ADEILKARTS VAFFPHGLGH YLGMDTHDVG 370 380 390 400 410 420 GTPNYADSDP MFRYLRKRGT LPAGSLVTVE PGIYFCSFII EPYLKDPTHS KYIDTDVLDK 430 440 450 460 YWDVGGVRIE DNLLITKTGS ENLTPTIKEP EEIEKFVGSS

References

[1]

"Annotation of Verticillium albo-atrum VaMs.102." The Broad Institute Genome Sequencing Platform Ma L.-J.J., Klosterman S.J., Subbarao K., Dobinson K., Veronese P., Kang S., Gold S.E., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D., Hepburn T., Sykes S., Chen Z., Alvarado L., Kodira C.D., Lander E. , Galagan J., Nusbaum C., Birren B. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VaMs.102 / ATCC MYA-4576 / FGSC 10136.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS985216 Genomic DNA. Translation: EEY16429.1.
RefSeq	XP_003006399.1. XM_003006353.1.
3D structure databases
ProteinModelPortal	C9SDK8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9535450.
KEGG	val:VDBG_02538.
Phylogenomic databases
KO	K14213.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_VERA1

Accession

Primary (citable) accession number: C9SDK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	November 24, 2009
Last modified:	March 6, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program