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Protein

Signal peptidase complex catalytic subunit SEC11

Gene

SEC11

Organism
Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11 (EC:3.4.21.89)
Alternative name(s):
Signal peptidase I
Gene namesi
Name:SEC11
ORF Names:VDBG_01459
OrganismiVerticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Taxonomic identifieri526221 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesPlectosphaerellaceaeVerticillium
Proteomesi
  • UP000008698 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414CytoplasmicSequence analysisAdd
BLAST
Transmembranei15 – 3521HelicalSequence analysisAdd
BLAST
Topological domaini36 – 13095LumenalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Topological domaini152 – 17221CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Signal peptidase complex catalytic subunit SEC11PRO_0000412371Add
BLAST

Interactioni

Subunit structurei

Component of the signal peptidase complex (SPC).By similarity

Protein-protein interaction databases

STRINGi526221.XP_003009776.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
KOiK13280.
OrthoDBiEOG092C4ZUJ.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9S8G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSLKNPRQ AAAQLLNFGL ILSTAFMMWK GLSVITDSPS PIVVVLSGSM
60 70 80 90 100
EPAFQRGDLL FLWNRNLLRE TDVGEVVVYN VKDKDIPIVH RIVRKFGAGA
110 120 130 140 150
SAKLLTKGDN NAADDTELYA RGQDYLERQD IIGSVVAYIP FVGYVTILLS
160 170
EHPWLKTVML GIMGLVVVLQ RE
Length:172
Mass (Da):19,061
Last modified:November 24, 2009 - v1
Checksum:iABB484B4F3FB83A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985214 Genomic DNA. Translation: EEY15350.1.
RefSeqiXP_003009776.1. XM_003009730.1.

Genome annotation databases

EnsemblFungiiEEY15350; EEY15350; VDBG_01459.
GeneIDi9536471.
KEGGival:VDBG_01459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985214 Genomic DNA. Translation: EEY15350.1.
RefSeqiXP_003009776.1. XM_003009730.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi526221.XP_003009776.1.

Protein family/group databases

MEROPSiS26.010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEY15350; EEY15350; VDBG_01459.
GeneIDi9536471.
KEGGival:VDBG_01459.

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
KOiK13280.
OrthoDBiEOG092C4ZUJ.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEC11_VERA1
AccessioniPrimary (citable) accession number: C9S8G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: November 24, 2009
Last modified: September 7, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.