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Protein

Signal peptidase complex catalytic subunit SEC11

Gene

SEC11

Organism
Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPSiS26.010

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11 (EC:3.4.21.89)
Alternative name(s):
Signal peptidase I
Gene namesi
Name:SEC11
ORF Names:VDBG_01459
OrganismiVerticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Taxonomic identifieri526221 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesPlectosphaerellaceaeVerticillium
Proteomesi
  • UP000008698 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 130LumenalSequence analysisAdd BLAST95
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 172CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004123711 – 172Signal peptidase complex catalytic subunit SEC11Add BLAST172

Interactioni

Subunit structurei

Component of the signal peptidase complex (SPC).By similarity

Protein-protein interaction databases

STRINGi526221.XP_003009776.1

Structurei

3D structure databases

SMRiC9S8G0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342 Eukaryota
COG0681 LUCA
KOiK13280
OrthoDBiEOG092C4ZUJ

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
IPR001733 Peptidase_S26B
PANTHERiPTHR10806 PTHR10806, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00728 SIGNALPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02228 sigpep_I_arch, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit

Sequencei

Sequence statusi: Complete.

C9S8G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSLKNPRQ AAAQLLNFGL ILSTAFMMWK GLSVITDSPS PIVVVLSGSM
60 70 80 90 100
EPAFQRGDLL FLWNRNLLRE TDVGEVVVYN VKDKDIPIVH RIVRKFGAGA
110 120 130 140 150
SAKLLTKGDN NAADDTELYA RGQDYLERQD IIGSVVAYIP FVGYVTILLS
160 170
EHPWLKTVML GIMGLVVVLQ RE
Length:172
Mass (Da):19,061
Last modified:November 24, 2009 - v1
Checksum:iABB484B4F3FB83A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985214 Genomic DNA Translation: EEY15350.1
RefSeqiXP_003009776.1, XM_003009730.1

Genome annotation databases

EnsemblFungiiEEY15350; EEY15350; VDBG_01459
GeneIDi9536471
KEGGival:VDBG_01459

Similar proteinsi

Entry informationi

Entry nameiSEC11_VERA1
AccessioniPrimary (citable) accession number: C9S8G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: November 24, 2009
Last modified: May 23, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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