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C9S688

- KEX1_VERA1

UniProt

C9S688 - KEX1_VERA1

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Protein
Pheromone-processing carboxypeptidase KEX1
Gene
KEX1, VDBG_00507
Organism
Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei176 – 1761 By similarity
Active sitei376 – 3761 By similarity
Active sitei438 – 4381 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:VDBG_00507
OrganismiVerticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Taxonomic identifieri526221 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesPlectosphaerellaceaemitosporic PlectosphaerellaceaeVerticillium
ProteomesiUP000008698: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 524500Lumenal Reviewed prediction
Add
BLAST
Transmembranei525 – 54521Helical; Reviewed prediction
Add
BLAST
Topological domaini546 – 63590Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 635611Pheromone-processing carboxypeptidase KEX1
PRO_0000411952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi427 – 4271N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi546 – 5516Poly-Arg

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C9S688-1 [UniParc]FASTAAdd to Basket

« Hide

MAPAIRQLAT GLLLALSWAP TTRADSSAAD YYVKSLPGQP AGPPVKMHAG    50
HIETDADHNG NLFFWHFENK HIAQRQRTVI WLNGGPGCSS EDGAMMEIGP 100
YRVKGDQLVN NNGSWHEFAN LLFVDNPVGT GFSYVDTNSY LHELDEMGDQ 150
FILFLEKFFK LFPQYAQDDL YFAGESYAGQ HIPYIAKHIL ERNEKAGPDD 200
QWNLKGLVIG NGWISPFEQY GSYLKFAYEK GLLAQGSEKA KQLEQQWKIC 250
RKQMAVDIKI DISECEAILQ KILDVTATLT TSGKRNCYNM YDVRLKDTYP 300
SCGMNWPPDL TDVTPYLRRK DVTEALHINA AKNTGWKECN GAVGSAFRAH 350
KSKPSRDLLP DLLKKVPITL FSGAEDLICN HIGTEEMIGN MEWNGAKGFE 400
VSPGNWAPRR DWTFEGKDAG FWQEARNLTY VLFKEASHMV PFDWPRRSRD 450
MIDRVMKVDI SAIGGEPTDS RIDGEKGPVT SVPPSKGSNN HPDTKPGGGD 500
KGSSTNDDET QKQVDEAKWK AYYRSGEIVL VIVVIAAGLW GWYIWRDRRR 550
RSGYQGVAGG DGAGPGHRAG ARGLDRFQDR RTARDVETGD FDESELDDLH 600
VETPREGPHK EAYAIGDDSD EEDIKGKGPE RSGTR 635
Length:635
Mass (Da):71,005
Last modified:November 24, 2009 - v1
Checksum:i23BDD5BA32051919
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS985214 Genomic DNA. Translation: EEY14400.1.
RefSeqiXP_003008826.1. XM_003008780.1.

Genome annotation databases

GeneIDi9529181.
KEGGival:VDBG_00507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS985214 Genomic DNA. Translation: EEY14400.1 .
RefSeqi XP_003008826.1. XM_003008780.1.

3D structure databases

ModBasei Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9529181.
KEGGi val:VDBG_00507.

Phylogenomic databases

KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VaMs.102 / ATCC MYA-4576 / FGSC 10136.

Entry informationi

Entry nameiKEX1_VERA1
AccessioniPrimary (citable) accession number: C9S688
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi