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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei176 – 1761By similarity
Active sitei376 – 3761By similarity
Active sitei438 – 4381By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.A67.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:VDBG_00507
OrganismiVerticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Taxonomic identifieri526221 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesPlectosphaerellaceaemitosporic PlectosphaerellaceaeVerticillium
ProteomesiUP000008698: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 524500LumenalSequence AnalysisAdd
BLAST
Transmembranei525 – 54521HelicalSequence AnalysisAdd
BLAST
Topological domaini546 – 63590CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 635611Pheromone-processing carboxypeptidase KEX1PRO_0000411952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi546 – 5516Poly-Arg

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C9S688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAIRQLAT GLLLALSWAP TTRADSSAAD YYVKSLPGQP AGPPVKMHAG
60 70 80 90 100
HIETDADHNG NLFFWHFENK HIAQRQRTVI WLNGGPGCSS EDGAMMEIGP
110 120 130 140 150
YRVKGDQLVN NNGSWHEFAN LLFVDNPVGT GFSYVDTNSY LHELDEMGDQ
160 170 180 190 200
FILFLEKFFK LFPQYAQDDL YFAGESYAGQ HIPYIAKHIL ERNEKAGPDD
210 220 230 240 250
QWNLKGLVIG NGWISPFEQY GSYLKFAYEK GLLAQGSEKA KQLEQQWKIC
260 270 280 290 300
RKQMAVDIKI DISECEAILQ KILDVTATLT TSGKRNCYNM YDVRLKDTYP
310 320 330 340 350
SCGMNWPPDL TDVTPYLRRK DVTEALHINA AKNTGWKECN GAVGSAFRAH
360 370 380 390 400
KSKPSRDLLP DLLKKVPITL FSGAEDLICN HIGTEEMIGN MEWNGAKGFE
410 420 430 440 450
VSPGNWAPRR DWTFEGKDAG FWQEARNLTY VLFKEASHMV PFDWPRRSRD
460 470 480 490 500
MIDRVMKVDI SAIGGEPTDS RIDGEKGPVT SVPPSKGSNN HPDTKPGGGD
510 520 530 540 550
KGSSTNDDET QKQVDEAKWK AYYRSGEIVL VIVVIAAGLW GWYIWRDRRR
560 570 580 590 600
RSGYQGVAGG DGAGPGHRAG ARGLDRFQDR RTARDVETGD FDESELDDLH
610 620 630
VETPREGPHK EAYAIGDDSD EEDIKGKGPE RSGTR
Length:635
Mass (Da):71,005
Last modified:November 24, 2009 - v1
Checksum:i23BDD5BA32051919
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985214 Genomic DNA. Translation: EEY14400.1.
RefSeqiXP_003008826.1. XM_003008780.1.

Genome annotation databases

GeneIDi9529181.
KEGGival:VDBG_00507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS985214 Genomic DNA. Translation: EEY14400.1.
RefSeqiXP_003008826.1. XM_003008780.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.A67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9529181.
KEGGival:VDBG_00507.

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VaMs.102 / ATCC MYA-4576 / FGSC 10136.

Entry informationi

Entry nameiKEX1_VERA1
AccessioniPrimary (citable) accession number: C9S688
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: November 24, 2009
Last modified: March 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.