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C9S688 (KEX1_VERA1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:VDBG_00507
OrganismVerticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum) [Complete proteome]
Taxonomic identifier526221 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesPlectosphaerellaceaemitosporic PlectosphaerellaceaeVerticillium

Protein attributes

Sequence length635 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 635611Pheromone-processing carboxypeptidase KEX1
PRO_0000411952

Regions

Topological domain25 – 524500Lumenal Potential
Transmembrane525 – 54521Helical; Potential
Topological domain546 – 63590Cytoplasmic Potential
Compositional bias546 – 5516Poly-Arg

Sites

Active site1761 By similarity
Active site3761 By similarity
Active site4381 By similarity

Amino acid modifications

Glycosylation1121N-linked (GlcNAc...) Potential
Glycosylation4271N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C9S688 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 23BDD5BA32051919

FASTA63571,005
        10         20         30         40         50         60 
MAPAIRQLAT GLLLALSWAP TTRADSSAAD YYVKSLPGQP AGPPVKMHAG HIETDADHNG 

        70         80         90        100        110        120 
NLFFWHFENK HIAQRQRTVI WLNGGPGCSS EDGAMMEIGP YRVKGDQLVN NNGSWHEFAN 

       130        140        150        160        170        180 
LLFVDNPVGT GFSYVDTNSY LHELDEMGDQ FILFLEKFFK LFPQYAQDDL YFAGESYAGQ 

       190        200        210        220        230        240 
HIPYIAKHIL ERNEKAGPDD QWNLKGLVIG NGWISPFEQY GSYLKFAYEK GLLAQGSEKA 

       250        260        270        280        290        300 
KQLEQQWKIC RKQMAVDIKI DISECEAILQ KILDVTATLT TSGKRNCYNM YDVRLKDTYP 

       310        320        330        340        350        360 
SCGMNWPPDL TDVTPYLRRK DVTEALHINA AKNTGWKECN GAVGSAFRAH KSKPSRDLLP 

       370        380        390        400        410        420 
DLLKKVPITL FSGAEDLICN HIGTEEMIGN MEWNGAKGFE VSPGNWAPRR DWTFEGKDAG 

       430        440        450        460        470        480 
FWQEARNLTY VLFKEASHMV PFDWPRRSRD MIDRVMKVDI SAIGGEPTDS RIDGEKGPVT 

       490        500        510        520        530        540 
SVPPSKGSNN HPDTKPGGGD KGSSTNDDET QKQVDEAKWK AYYRSGEIVL VIVVIAAGLW 

       550        560        570        580        590        600 
GWYIWRDRRR RSGYQGVAGG DGAGPGHRAG ARGLDRFQDR RTARDVETGD FDESELDDLH 

       610        620        630 
VETPREGPHK EAYAIGDDSD EEDIKGKGPE RSGTR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS985214 Genomic DNA. Translation: EEY14400.1.
RefSeqXP_003008826.1. XM_003008780.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9529181.
KEGGval:VDBG_00507.

Phylogenomic databases

KOK01288.
OrthoDBEOG7TJ3SJ.

Family and domain databases

InterProIPR001563. Peptidase_S10.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
ProtoNetSearch...

Entry information

Entry nameKEX1_VERA1
AccessionPrimary (citable) accession number: C9S688
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: November 24, 2009
Last modified: February 19, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries