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C9S688

- KEX1_VERA1

UniProt

C9S688 - KEX1_VERA1

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei176 – 1761By similarity
    Active sitei376 – 3761By similarity
    Active sitei438 – 4381By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:VDBG_00507
    OrganismiVerticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
    Taxonomic identifieri526221 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesPlectosphaerellaceaemitosporic PlectosphaerellaceaeVerticillium
    ProteomesiUP000008698: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 635611Pheromone-processing carboxypeptidase KEX1PRO_0000411952Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 524500LumenalSequence AnalysisAdd
    BLAST
    Topological domaini546 – 63590CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei525 – 54521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi546 – 5516Poly-Arg

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C9S688-1 [UniParc]FASTAAdd to Basket

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    MAPAIRQLAT GLLLALSWAP TTRADSSAAD YYVKSLPGQP AGPPVKMHAG    50
    HIETDADHNG NLFFWHFENK HIAQRQRTVI WLNGGPGCSS EDGAMMEIGP 100
    YRVKGDQLVN NNGSWHEFAN LLFVDNPVGT GFSYVDTNSY LHELDEMGDQ 150
    FILFLEKFFK LFPQYAQDDL YFAGESYAGQ HIPYIAKHIL ERNEKAGPDD 200
    QWNLKGLVIG NGWISPFEQY GSYLKFAYEK GLLAQGSEKA KQLEQQWKIC 250
    RKQMAVDIKI DISECEAILQ KILDVTATLT TSGKRNCYNM YDVRLKDTYP 300
    SCGMNWPPDL TDVTPYLRRK DVTEALHINA AKNTGWKECN GAVGSAFRAH 350
    KSKPSRDLLP DLLKKVPITL FSGAEDLICN HIGTEEMIGN MEWNGAKGFE 400
    VSPGNWAPRR DWTFEGKDAG FWQEARNLTY VLFKEASHMV PFDWPRRSRD 450
    MIDRVMKVDI SAIGGEPTDS RIDGEKGPVT SVPPSKGSNN HPDTKPGGGD 500
    KGSSTNDDET QKQVDEAKWK AYYRSGEIVL VIVVIAAGLW GWYIWRDRRR 550
    RSGYQGVAGG DGAGPGHRAG ARGLDRFQDR RTARDVETGD FDESELDDLH 600
    VETPREGPHK EAYAIGDDSD EEDIKGKGPE RSGTR 635
    Length:635
    Mass (Da):71,005
    Last modified:November 24, 2009 - v1
    Checksum:i23BDD5BA32051919
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS985214 Genomic DNA. Translation: EEY14400.1.
    RefSeqiXP_003008826.1. XM_003008780.1.

    Genome annotation databases

    GeneIDi9529181.
    KEGGival:VDBG_00507.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS985214 Genomic DNA. Translation: EEY14400.1 .
    RefSeqi XP_003008826.1. XM_003008780.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9529181.
    KEGGi val:VDBG_00507.

    Phylogenomic databases

    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VaMs.102 / ATCC MYA-4576 / FGSC 10136.

    Entry informationi

    Entry nameiKEX1_VERA1
    AccessioniPrimary (citable) accession number: C9S688
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3