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Protein

Beta-galactosidase BgaB

Gene

bgaB

Organism
Geobacillus sp. (strain Y412MC61)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091SubstrateBy similarity
Metal bindingi113 – 1131ZincBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Active sitei148 – 1481Proton donorBy similarity
Metal bindingi156 – 1561ZincBy similarity
Metal bindingi158 – 1581ZincBy similarity
Metal bindingi161 – 1611ZincBy similarity
Active sitei303 – 3031NucleophileBy similarity
Binding sitei311 – 3111SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciGSP544556:GI3L-565-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase BgaB (EC:3.2.1.23)
Short name:
Beta-galBy similarity
Alternative name(s):
Beta-galactosidase IBy similarity
LactaseBy similarity
Gene namesi
Name:bgaBBy similarity
Ordered Locus Names:GYMC61_0530
OrganismiGeobacillus sp. (strain Y412MC61)
Taxonomic identifieri544556 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 672672Beta-galactosidase BgaBPRO_0000407689Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC9S0R2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni351 – 3544Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the glycosyl hydrolase 42 family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000117811.
KOiK12308.
OMAiDWENWWA.
OrthoDBiEOG6GTZGG.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR013739. Beta_galactosidase_C.
IPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02449. Glyco_hydro_42. 1 hit.
PF08533. Glyco_hydro_42C. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view]
PIRSFiPIRSF001084. B-galactosidase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.

Sequencei

Sequence statusi: Complete.

C9S0R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVLSSICYG GDYNPEQWPE EIWYEDAKLM QKAGVNLVSL GIFSWSKIEP
60 70 80 90 100
SDGVFDFEWL DKVIDILYDH GVYINLGTAT ATTPAWFVKK YPDSLPIDES
110 120 130 140 150
GVIFSFGSRQ HYCPNHPQLI THIKRLVRAI AERYKNHPAL KMWHVNNEYA
160 170 180 190 200
CHVSKCFCEN CAVAFRKWLK ERYKTIDELN ERWGTNFWGQ RYNHWDEINP
210 220 230 240 250
PRKAPTFINP SQELDYYRFM NDSILKLFLT EKEILRGVTP DIPVSTNFMG
260 270 280 290 300
SFKPLNYFQW AQHVDIVTWD SYPDPREGLP IQHAMMNDLM RSLRKGQPFI
310 320 330 340 350
LMEQVTSHVN WRDINVPKPP GVMRLWSYAT IARGADGIMF FQWRQSRAGA
360 370 380 390 400
EKFHGAMVPH FLNENNRIYR EVTQLGQELK KLDCLVGSRI KAEVAIIFDW
410 420 430 440 450
ENWWAVELSS KPHNKLRYIP IVEAYYRELY KRNIAVDFVR PSDDLTKYKV
460 470 480 490 500
VIAPMLYMVK EGEDENLRQF VANGGTLIVS FFSGIVDEND RVHLGGYPGP
510 520 530 540 550
LRDILGIFVE EFVPYPETKV NKIYSNDGEY DCTTWADIIR LEGAEPLATF
560 570 580 590 600
KGDWYAGLPA VTRNCYGKGE GIYVGTYPDS NYLGRLLEQV FAKHHINPIL
610 620 630 640 650
EVAENVEVQQ RETDEWKYLI IINHNDYEVT LSLPEDKIYQ NMIDGKCFRG
660 670
GELRIQGVDV AVLREHDEAG KV
Length:672
Mass (Da):78,015
Last modified:November 24, 2009 - v1
Checksum:i5B4573522E398425
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001794 Genomic DNA. Translation: ACX77212.1.
RefSeqiWP_013524100.1. NC_013411.1.

Genome annotation databases

EnsemblBacteriaiACX77212; ACX77212; GYMC61_0530.
KEGGigyc:GYMC61_0530.
PATRICi32162521. VBIGeoSp85804_0561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001794 Genomic DNA. Translation: ACX77212.1.
RefSeqiWP_013524100.1. NC_013411.1.

3D structure databases

ProteinModelPortaliC9S0R2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX77212; ACX77212; GYMC61_0530.
KEGGigyc:GYMC61_0530.
PATRICi32162521. VBIGeoSp85804_0561.

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000117811.
KOiK12308.
OMAiDWENWWA.
OrthoDBiEOG6GTZGG.

Enzyme and pathway databases

BioCyciGSP544556:GI3L-565-MONOMER.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR013739. Beta_galactosidase_C.
IPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02449. Glyco_hydro_42. 1 hit.
PF08533. Glyco_hydro_42C. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view]
PIRSFiPIRSF001084. B-galactosidase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Geobacillus sp. Y412MC61."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Brumm P., Mead D.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y412MC61Imported.

Entry informationi

Entry nameiBGAL_GEOSY
AccessioniPrimary (citable) accession number: C9S0R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: November 24, 2009
Last modified: July 22, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.