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C9RWQ1

- C9RWQ1_GEOSY

UniProt

C9RWQ1 - C9RWQ1_GEOSY

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Protein

Thymidine kinase

Gene

tdk

Organism
Geobacillus sp. (strain Y412MC61)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptorUniRule annotation
Metal bindingi145 – 1451ZincUniRule annotation
Metal bindingi148 – 1481ZincUniRule annotation
Metal bindingi183 – 1831ZincUniRule annotation
Metal bindingi186 – 1861ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATPUniRule annotation
Nucleotide bindingi88 – 914ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGSP544556:GI3L-3554-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:GYMC61_3437Imported
OrganismiGeobacillus sp. (strain Y412MC61)Imported
Taxonomic identifieri544556 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000008468: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi544556.GYMC61_3437.

Structurei

3D structure databases

ProteinModelPortaliC9RWQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiTMRKTEE.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9RWQ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYVMTQSGWL EVICGCMFSG KSEELIRRVR RAQFAKQEVK VFKPTIDNRY
60 70 80 90 100
SEDAVVSHNG NSVIAIPVAT PAEMFRYISA ATDVVAIDEV QFFSDDIIDV
110 120 130 140 150
VQTLADGGCR VIAAGLDQDF RGEPFGPVPA LMAIAESVTK LQAVCTVCGS
160 170 180 190 200
PASRTQRLIN GAPASYDDPV ILVGASEAYE PRCRHHHEVP GKPKKRYNRP

LAGHTGE
Length:207
Mass (Da):22,583
Last modified:November 24, 2009 - v1
Checksum:i9C92F9565C9B2C66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001794 Genomic DNA. Translation: ACX79985.1.
RefSeqiYP_003254467.1. NC_013411.1.

Genome annotation databases

EnsemblBacteriaiACX79985; ACX79985; GYMC61_3437.
GeneIDi8527325.
KEGGigyc:GYMC61_3437.
PATRICi32168775. VBIGeoSp85804_3607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001794 Genomic DNA. Translation: ACX79985.1 .
RefSeqi YP_003254467.1. NC_013411.1.

3D structure databases

ProteinModelPortali C9RWQ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 544556.GYMC61_3437.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACX79985 ; ACX79985 ; GYMC61_3437 .
GeneIDi 8527325.
KEGGi gyc:GYMC61_3437.
PATRICi 32168775. VBIGeoSp85804_3607.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi TMRKTEE.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci GSP544556:GI3L-3554-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Geobacillus sp. Y412MC61."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Brumm P., Mead D.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y412MC61Imported.

Entry informationi

Entry nameiC9RWQ1_GEOSY
AccessioniPrimary (citable) accession number: C9RWQ1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: November 26, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3