Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Fibrobacter succinogenes (strain ATCC 19169 / S85)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi20Metal cation 1UniRule annotation1
Metal bindingi22Metal cation 1UniRule annotation1
Binding sitei22cAMPUniRule annotation1
Metal bindingi59Metal cation 1UniRule annotation1
Metal bindingi59Metal cation 2UniRule annotation1
Binding sitei59cAMPUniRule annotation1
Metal bindingi89Metal cation 2UniRule annotation1
Metal bindingi156Metal cation 2UniRule annotation1
Metal bindingi196Metal cation 2UniRule annotation1
Metal bindingi198Metal cation 1UniRule annotation1
Binding sitei198cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi89 – 90cAMPUniRule annotation2

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFSUC59374:G1GMS-1838-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:Fisuc_1441, FSU_1912
OrganismiFibrobacter succinogenes (strain ATCC 19169 / S85)
Taxonomic identifieri59374 [NCBI]
Taxonomic lineageiBacteriaFibrobacteresFibrobacteralesFibrobacteraceaeFibrobacter
Proteomesi
  • UP000000517 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133681 – 2563',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST256

Proteomic databases

PRIDEiC9RR52

Interactioni

Protein-protein interaction databases

STRINGi59374.FSU_1912

Structurei

3D structure databases

ProteinModelPortaliC9RR52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41083VT Bacteria
COG1409 LUCA
KOiK03651

Family and domain databases

Gene3Di3.60.21.10, 1 hit
HAMAPiMF_00905 cAMP_phophodiest_CpdA, 1 hit
InterProiView protein in InterPro
IPR024654 Calcineurin-like_PHP_lpxH
IPR026575 cAMP_Pdiest_CpdA
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF12850 Metallophos_2, 1 hit

Sequencei

Sequence statusi: Complete.

C9RR52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYILRSCMEK KVLKIGQISD AHIGDDDRLV QDIDVRKNFL TAYNSESMKD
60 70 80 90 100
LDLLVLSGDL ADNASTDAYS FIAGVIKDSK VPVCIIPGNH DNLEVMEKVF
110 120 130 140 150
DLKDKVHNGK CYYRYDLDGR SIFFLDSADG TVSSDQLSWL EQETAKIDGE
160 170 180 190 200
VLLFLHHPPC LCGHKFMDLR YSMKNIAEVQ ATLSKIKNLK HIFVGHYHSE
210 220 230 240 250
MTIQLEDKTV YVTPSTQMQI DPNITVFCLS SAAPRWRLIE WGENFMETKV

YFSNTP
Length:256
Mass (Da):29,186
Last modified:October 19, 2011 - v2
Checksum:i136B36E74CCA0D3A
GO

Sequence cautioni

The sequence ACX75038 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001792 Genomic DNA Translation: ACX75038.1 Different initiation.
CP002158 Genomic DNA Translation: ADL25604.1
RefSeqiWP_014546132.1, NC_017448.1

Genome annotation databases

EnsemblBacteriaiACX75038; ACX75038; Fisuc_1441
ADL25604; ADL25604; FSU_1912
GeneIDi34755785
KEGGifsc:FSU_1912
fsu:Fisuc_1441
PATRICifig|59374.8.peg.1844

Similar proteinsi

Entry informationi

Entry nameiCPDA_FIBSS
AccessioniPrimary (citable) accession number: C9RR52
Secondary accession number(s): D9SBF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: May 23, 2018
This is version 46 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health