SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C9RR52

- CPDA_FIBSS

UniProt

C9RR52 - CPDA_FIBSS

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene
cpdA, Fisuc_1441, FSU_1912
Organism
Fibrobacter succinogenes (strain ATCC 19169 / S85)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201Metal cation 1 By similarity
Metal bindingi22 – 221Metal cation 1 By similarity
Binding sitei22 – 221cAMP By similarity
Metal bindingi59 – 591Metal cation 1 By similarity
Metal bindingi59 – 591Metal cation 2 By similarity
Binding sitei59 – 591cAMP By similarity
Metal bindingi89 – 891Metal cation 2 By similarity
Metal bindingi156 – 1561Metal cation 2 By similarity
Metal bindingi196 – 1961Metal cation 2 By similarity
Metal bindingi198 – 1981Metal cation 1 By similarity
Binding sitei198 – 1981cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 902cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Ordered Locus Names:Fisuc_1441, FSU_1912
OrganismiFibrobacter succinogenes (strain ATCC 19169 / S85)
Taxonomic identifieri59374 [NCBI]
Taxonomic lineageiBacteriaFibrobacteresFibrobacteralesFibrobacteraceaeFibrobacter
ProteomesiUP000000517: Chromosome, UP000001497: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2562563',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotationPRO_0000413368Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59374.Fisuc_1441.

Structurei

3D structure databases

ProteinModelPortaliC9RR52.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1409.
KOiK03651.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF12850. Metallophos_2. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

C9RR52-1 [UniParc]FASTAAdd to Basket

« Hide

MYILRSCMEK KVLKIGQISD AHIGDDDRLV QDIDVRKNFL TAYNSESMKD    50
LDLLVLSGDL ADNASTDAYS FIAGVIKDSK VPVCIIPGNH DNLEVMEKVF 100
DLKDKVHNGK CYYRYDLDGR SIFFLDSADG TVSSDQLSWL EQETAKIDGE 150
VLLFLHHPPC LCGHKFMDLR YSMKNIAEVQ ATLSKIKNLK HIFVGHYHSE 200
MTIQLEDKTV YVTPSTQMQI DPNITVFCLS SAAPRWRLIE WGENFMETKV 250
YFSNTP 256
Length:256
Mass (Da):29,186
Last modified:October 19, 2011 - v2
Checksum:i136B36E74CCA0D3A
GO

Sequence cautioni

The sequence ACX75038.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001792 Genomic DNA. Translation: ACX75038.1. Different initiation.
CP002158 Genomic DNA. Translation: ADL25604.1.
RefSeqiWP_014546132.1. NC_017448.1.
YP_003249520.1. NC_013410.1.
YP_005821847.1. NC_017448.1.

Genome annotation databases

EnsemblBacteriaiACX75038; ACX75038; Fisuc_1441.
ADL25604; ADL25604; FSU_1912.
GeneIDi12433470.
8522047.
KEGGifsc:FSU_1912.
fsu:Fisuc_1441.
PATRICi32142651. VBIFibSuc28982_1412.
43021265. VBIFibSuc28982203727_1844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001792 Genomic DNA. Translation: ACX75038.1 . Different initiation.
CP002158 Genomic DNA. Translation: ADL25604.1 .
RefSeqi WP_014546132.1. NC_017448.1.
YP_003249520.1. NC_013410.1.
YP_005821847.1. NC_017448.1.

3D structure databases

ProteinModelPortali C9RR52.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59374.Fisuc_1441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACX75038 ; ACX75038 ; Fisuc_1441 .
ADL25604 ; ADL25604 ; FSU_1912 .
GeneIDi 12433470.
8522047.
KEGGi fsc:FSU_1912.
fsu:Fisuc_1441.
PATRICi 32142651. VBIFibSuc28982_1412.
43021265. VBIFibSuc28982203727_1844.

Phylogenomic databases

eggNOGi COG1409.
KOi K03651.
OrthoDBi EOG6QG8GQ.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF12850. Metallophos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Weimer P.J.
    , Stevenson D.M., Boyum J., Brumm P.I., Mead D.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19169 / S85.
  2. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
    Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B., Russell J.B., Cann I.K.O., Mackie R.I., White B.A.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19169 / S85.

Entry informationi

Entry nameiCPDA_FIBSS
AccessioniPrimary (citable) accession number: C9RR52
Secondary accession number(s): D9SBF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: September 3, 2014
This is version 26 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi