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C9RR52

- CPDA_FIBSS

UniProt

C9RR52 - CPDA_FIBSS

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Fibrobacter succinogenes (strain ATCC 19169 / S85)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 2 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi20 – 201Metal cation 1UniRule annotation
    Metal bindingi22 – 221Metal cation 1UniRule annotation
    Binding sitei22 – 221cAMPUniRule annotation
    Metal bindingi59 – 591Metal cation 1UniRule annotation
    Metal bindingi59 – 591Metal cation 2UniRule annotation
    Binding sitei59 – 591cAMPUniRule annotation
    Metal bindingi89 – 891Metal cation 2UniRule annotation
    Metal bindingi156 – 1561Metal cation 2UniRule annotation
    Metal bindingi196 – 1961Metal cation 2UniRule annotation
    Metal bindingi198 – 1981Metal cation 1UniRule annotation
    Binding sitei198 – 1981cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi89 – 902cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:Fisuc_1441, FSU_1912
    OrganismiFibrobacter succinogenes (strain ATCC 19169 / S85)
    Taxonomic identifieri59374 [NCBI]
    Taxonomic lineageiBacteriaFibrobacteresFibrobacteralesFibrobacteraceaeFibrobacter
    ProteomesiUP000000517: Chromosome, UP000001497: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2562563',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413368Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi59374.Fisuc_1441.

    Structurei

    3D structure databases

    ProteinModelPortaliC9RR52.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1409.
    KOiK03651.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF12850. Metallophos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C9RR52-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYILRSCMEK KVLKIGQISD AHIGDDDRLV QDIDVRKNFL TAYNSESMKD    50
    LDLLVLSGDL ADNASTDAYS FIAGVIKDSK VPVCIIPGNH DNLEVMEKVF 100
    DLKDKVHNGK CYYRYDLDGR SIFFLDSADG TVSSDQLSWL EQETAKIDGE 150
    VLLFLHHPPC LCGHKFMDLR YSMKNIAEVQ ATLSKIKNLK HIFVGHYHSE 200
    MTIQLEDKTV YVTPSTQMQI DPNITVFCLS SAAPRWRLIE WGENFMETKV 250
    YFSNTP 256
    Length:256
    Mass (Da):29,186
    Last modified:October 19, 2011 - v2
    Checksum:i136B36E74CCA0D3A
    GO

    Sequence cautioni

    The sequence ACX75038.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001792 Genomic DNA. Translation: ACX75038.1. Different initiation.
    CP002158 Genomic DNA. Translation: ADL25604.1.
    RefSeqiWP_014546132.1. NC_017448.1.
    YP_003249520.1. NC_013410.1.
    YP_005821847.1. NC_017448.1.

    Genome annotation databases

    EnsemblBacteriaiACX75038; ACX75038; Fisuc_1441.
    ADL25604; ADL25604; FSU_1912.
    GeneIDi12433470.
    8522047.
    KEGGifsc:FSU_1912.
    fsu:Fisuc_1441.
    PATRICi32142651. VBIFibSuc28982_1412.
    43021265. VBIFibSuc28982203727_1844.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001792 Genomic DNA. Translation: ACX75038.1 . Different initiation.
    CP002158 Genomic DNA. Translation: ADL25604.1 .
    RefSeqi WP_014546132.1. NC_017448.1.
    YP_003249520.1. NC_013410.1.
    YP_005821847.1. NC_017448.1.

    3D structure databases

    ProteinModelPortali C9RR52.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59374.Fisuc_1441.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACX75038 ; ACX75038 ; Fisuc_1441 .
    ADL25604 ; ADL25604 ; FSU_1912 .
    GeneIDi 12433470.
    8522047.
    KEGGi fsc:FSU_1912.
    fsu:Fisuc_1441.
    PATRICi 32142651. VBIFibSuc28982_1412.
    43021265. VBIFibSuc28982203727_1844.

    Phylogenomic databases

    eggNOGi COG1409.
    KOi K03651.
    OrthoDBi EOG6QG8GQ.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF12850. Metallophos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Weimer P.J.
      , Stevenson D.M., Boyum J., Brumm P.I., Mead D.
      Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19169 / S85.
    2. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
      Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B., Russell J.B., Cann I.K.O., Mackie R.I., White B.A.
      Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19169 / S85.

    Entry informationi

    Entry nameiCPDA_FIBSS
    AccessioniPrimary (citable) accession number: C9RR52
    Secondary accession number(s): D9SBF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3