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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Fibrobacter succinogenes (strain ATCC 19169 / S85)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi20Metal cation 1UniRule annotation1
Metal bindingi22Metal cation 1UniRule annotation1
Binding sitei22cAMPUniRule annotation1
Metal bindingi59Metal cation 1UniRule annotation1
Metal bindingi59Metal cation 2UniRule annotation1
Binding sitei59cAMPUniRule annotation1
Metal bindingi89Metal cation 2UniRule annotation1
Metal bindingi156Metal cation 2UniRule annotation1
Metal bindingi196Metal cation 2UniRule annotation1
Metal bindingi198Metal cation 1UniRule annotation1
Binding sitei198cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi89 – 90cAMPUniRule annotation2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:Fisuc_1441, FSU_1912
OrganismiFibrobacter succinogenes (strain ATCC 19169 / S85)
Taxonomic identifieri59374 [NCBI]
Taxonomic lineageiBacteriaFibrobacteresFibrobacteralesFibrobacteraceaeFibrobacter
Proteomesi
  • UP000000517 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133681 – 2563',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST256

Interactioni

Protein-protein interaction databases

STRINGi59374.FSU_1912.

Structurei

3D structure databases

ProteinModelPortaliC9RR52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41083VT. Bacteria.
COG1409. LUCA.
KOiK03651.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

C9RR52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYILRSCMEK KVLKIGQISD AHIGDDDRLV QDIDVRKNFL TAYNSESMKD
60 70 80 90 100
LDLLVLSGDL ADNASTDAYS FIAGVIKDSK VPVCIIPGNH DNLEVMEKVF
110 120 130 140 150
DLKDKVHNGK CYYRYDLDGR SIFFLDSADG TVSSDQLSWL EQETAKIDGE
160 170 180 190 200
VLLFLHHPPC LCGHKFMDLR YSMKNIAEVQ ATLSKIKNLK HIFVGHYHSE
210 220 230 240 250
MTIQLEDKTV YVTPSTQMQI DPNITVFCLS SAAPRWRLIE WGENFMETKV

YFSNTP
Length:256
Mass (Da):29,186
Last modified:October 19, 2011 - v2
Checksum:i136B36E74CCA0D3A
GO

Sequence cautioni

The sequence ACX75038 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001792 Genomic DNA. Translation: ACX75038.1. Different initiation.
CP002158 Genomic DNA. Translation: ADL25604.1.
RefSeqiWP_014546132.1. NC_017448.1.

Genome annotation databases

EnsemblBacteriaiACX75038; ACX75038; Fisuc_1441.
ADL25604; ADL25604; FSU_1912.
KEGGifsc:FSU_1912.
fsu:Fisuc_1441.
PATRICi32142651. VBIFibSuc28982_1412.
43021265. VBIFibSuc28982203727_1844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001792 Genomic DNA. Translation: ACX75038.1. Different initiation.
CP002158 Genomic DNA. Translation: ADL25604.1.
RefSeqiWP_014546132.1. NC_017448.1.

3D structure databases

ProteinModelPortaliC9RR52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59374.FSU_1912.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX75038; ACX75038; Fisuc_1441.
ADL25604; ADL25604; FSU_1912.
KEGGifsc:FSU_1912.
fsu:Fisuc_1441.
PATRICi32142651. VBIFibSuc28982_1412.
43021265. VBIFibSuc28982203727_1844.

Phylogenomic databases

eggNOGiENOG41083VT. Bacteria.
COG1409. LUCA.
KOiK03651.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPDA_FIBSS
AccessioniPrimary (citable) accession number: C9RR52
Secondary accession number(s): D9SBF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: November 30, 2016
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.