C9RQC3 (C9RQC3_FIBSS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine synthase HAMAP-Rule MF_00419
Short name=FGAM synthase HAMAP-Rule MF_00419
Short name=FGAMS HAMAP-Rule MF_00419
EC=6.3.5.3 HAMAP-Rule MF_00419

Alternative name(s):
Formylglycinamide ribotide amidotransferase HAMAP-Rule MF_00419
Formylglycinamide ribotide synthetase HAMAP-Rule MF_00419

Gene names

Name:	purL HAMAP-Rule MF_00419
Ordered Locus Names:	Fisuc_3090, FSU_0356

Organism

Fibrobacter succinogenes (strain ATCC 19169 / S85) [Complete proteome] [HAMAP] EMBL ACX76670.1

Taxonomic identifier

59374 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Fibrobacteres/Acidobacteria group › Fibrobacteres › Fibrobacteria › Fibrobacterales › Fibrobacteraceae › Fibrobacter › Fibrobacter succinogenes › Fibrobacter succinogenes subsp. succinogenes

Protein attributes

Sequence length	1291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00419
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00419
Subunit structure	Monomer By similarity. HAMAP-Rule MF_00419
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00419.
Sequence similarities	Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_00419 In the N-terminal section; belongs to the FGAMS family. HAMAP-Rule MF_00419

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP-Rule MF_00419
Cellular component	Cytoplasm HAMAP-Rule MF_00419
Domain	Glutamine amidotransferase HAMAP-Rule MF_00419
Ligand	ATP-binding HAMAP-Rule MF_00419 Nucleotide-binding
Molecular function	Ligase HAMAP-Rule MF_00419 EMBL ACX76670.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway glutamine metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphoribosylformylglycinamidine synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	307 – 318	12	ATP By similarity HAMAP-Rule MF_00419
Sites
	Active site	1131	1	Nucleophile By similarity HAMAP-Rule MF_00419
	Active site	1256	1	By similarity HAMAP-Rule MF_00419
	Active site	1258	1	By similarity HAMAP-Rule MF_00419

Sequences

	Sequence		Length	Mass (Da)
	C9RQC3 [UniParc]. Last modified November 24, 2009. Version 1. Checksum: 720C1082F73A0DD5	FASTA	1,291	140,004
	10 20 30 40 50 60 MLILRGTPAL SDFRLQKLSS DFKAAGIPVA SVYAEFLHVV DLSADLTASE KETLEKVLHY 70 80 90 100 110 120 GPMREVKALE GELFVVCPRP GTISPWSSKA TDIAHICGLP AIKRIERAIA YYVKFEGAAP 130 140 150 160 170 180 AGAREKISAK IHDRMTQAVF ADTAALEVLF SKEEPRPLNV IPVLTEGRNA LVKADKEMGL 190 200 210 220 230 240 ALSADEIDYL VKNFTELKRN PTDVELYMFA QANSEHCRHK VFGAEWTIDG VKQDKSLFQM 250 260 270 280 290 300 IKNTYQLHNS NIFSAYKDNA AVMKGATAGR FYADPRNNKY DFHNEEVDIL MKVETHNHPT 310 320 330 340 350 360 AISPFPGAAT GSGGEIRDEG ATGKGSKPKA GLTGFSVSNL KLPGAVQPWE KDFGSPSRIA 370 380 390 400 410 420 SALDIMIDGP LGGAAFNNEY GRPNILGYFR TFEQEVNAQN GKEVRGYHKP IMLAGGLGNI 430 440 450 460 470 480 KHQHIEKGHI DPGDHLIVLG GPAMLIGLGG GAASSVANGA GNESLDFASV QRENPEMERR 490 500 510 520 530 540 CQEVIDRCWA MNEENPITFI HDVGAGGLSN AFPELVNDGG LGGKFELRNV PNDEPGMSPF 550 560 570 580 590 600 EIWSNESQER YVIAIAGDKL DVFDAICKRE RCPYAVVGEA IPEKHLTLTD KHFGTTPIDM 610 620 630 640 650 660 PLGVLLGKPP RMIRNEKSQK RPLSSQVVPA GVTVKDLAHR VLANPTVADK TFLISIGDRS 670 680 690 700 710 720 VTGMICRDQM VGPWQVPVAD CAVTSATLDT YEGEVMSMGE RAPIALISPA AAARMTVAES 730 740 750 760 770 780 LTNMAAACVP DMGRVNLSAN WMATPNYEGD GADLYEAVKS IGMELCPELG ITIPVGKDSM 790 800 810 820 830 840 SMSTVWQDEK GSHRVTAPIS LVISAFAPCA DVRKTLTPQL LQKKDTTLVL VDLARGKNRM 850 860 870 880 890 900 GASIAAQVYN LLGDKAPDVD SAKELRAFFE TIQKLNADGK IMAYHDKSDG GLFTTVVEMA 910 920 930 940 950 960 FAGHVGVTLD ATALKGNVID ALFNEELGAV LQVANADLAA VKAAFEAVGL GDTVSEIGKL 970 980 990 1000 1010 1020 NDTYNIVIGD YAEGLSDLRA IWSDTTRRIA ALRDNPECAE SEYKLKLEQD DPGITPKVTF 1030 1040 1050 1060 1070 1080 DLAASAKIIK DYASRPKMAI LREQGVNGEL EMAAAFAKAG FESIDVHMTD ILSGRVSLKD 1090 1100 1110 1120 1130 1140 FNGLVACGGF SYGDVLGAGE GWAKSILFNP KARAEFEAYF NRKDTFTLGV CNGCQMVSNL 1150 1160 1170 1180 1190 1200 KDLIPGAKHW PRFVQNISER FEARYCSLKV EDTPAVLLKG MAGSVLPIAV AHGEGRAEFA 1210 1220 1230 1240 1250 1260 SREAAEACLK TGLVALRYVD GKHEYTERYP LNPNGSPFGI NGLCSEDGRA LVMMPHPERV 1270 1280 1290 FRTCQYSWHP AEWGEDGPWM QLFRNGRIFV G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Weimer P.J. , Stevenson D.M., Boyum J., Brumm P.I., Mead D. Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19169 / S85.
[2]	"Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85." Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B., Russell J.B., Cann I.K.O., Mackie R.I., White B.A. Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19169 / S85.
[3]	Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B., Russell J.B., Cann I.K.O., Mackie R.I., White B.A. Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: S85.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001792 Genomic DNA. Translation: ACX76670.1. CP002158 Genomic DNA. Translation: ADL26724.1.
RefSeq	YP_003251152.1. NC_013410.1. YP_005820502.1. NC_017448.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	59374.Fisuc_3090.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACX76670; ACX76670; Fisuc_3090. ADL26724; ADL26724; FSU_0356.
GeneID	12431999. 8523737.
KEGG	fsc:FSU_0356. fsu:Fisuc_3090.
PATRIC	32145935. VBIFibSuc28982_3015.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0046.
HOGENOM	HOG000261358.
KO	K01952.
OMA	TVKAVGM.
Enzyme and pathway databases
UniPathway	UPA00074; UER00128.
Family and domain databases
HAMAP	MF_00419. PurL_1.
InterPro	IPR010918. AIR_synth_C_dom. IPR000728. AIR_synth_N_dom. IPR017926. GATASE_1. IPR010073. PRibForGlyAmidine_synth. IPR022940. PRibForGlyAmidine_synth_bac. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 2 hits. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 2 hits. SSF55326. PurM_N-like. 2 hits.
TIGRFAMs	TIGR01735. FGAM_synt. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C9RQC3_FIBSS

Accession

Primary (citable) accession number: C9RQC3

Entry history

Integrated into UniProtKB/TrEMBL:	November 24, 2009
Last sequence update:	November 24, 2009
Last modified:	May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)