C9RG41 (C9RG41_METVM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine synthase 2 HAMAP MF_00420
EC=6.3.5.3 HAMAP MF_00420

Alternative name(s):
Phosphoribosylformylglycinamidine synthase II HAMAP MF_00420

Gene names

Name:	purL HAMAP MF_00420
Ordered Locus Names:	Metvu_0685

Organism

Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius) [Complete proteome] [HAMAP]

Taxonomic identifier

579137 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	733 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP MF_00420
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP MF_00420
Subunit structure	Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP MF_00420
Subcellular location	Cytoplasm By similarity HAMAP MF_00420.
Sequence similarities	Belongs to the FGAMS family. HAMAP MF_00420

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00420
Cellular component	Cytoplasm HAMAP MF_00420
Ligand	ATP-binding HAMAP MF_00420 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00420 EMBL ACX72543.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphoribosylformylglycinamidine synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C9RG41 [UniParc]. Last modified November 24, 2009. Version 1. Checksum: D671295B8C7607BC	FASTA	733	80,778
	10 20 30 40 50 60 MDENDIKYIE NTLGRKLNDI ELAMFENLWS EHCAYRTSKK LLRMFAKTVN EKTSKNIVVG 70 80 90 100 110 120 IGDDAAIIRL KDDICLAIAM ESHNHPSYID PYNGAATGVG GIVRDVLSMG AKPIALLDPL 130 140 150 160 170 180 RFGDIFGKEG DKVRWLIDGV VRGIGDYGNR IGVPTVGGEC EFDSSFDYNN LVNVVCVGLV 190 200 210 220 230 240 KENEIITGKA KEPGLSLILV GSTGRDGIGG ASFASKDLTE ESEEDRPSVQ VGDAFSEKCL 250 260 270 280 290 300 IDAVLEAVKT GKVKAMKDLG AAGLSGASSE MCYGGGVGCE LYLENVILRE PLTPYEIMIS 310 320 330 340 350 360 ESQERMLLAV EPGSEEEIIE IFKKYELPAS VIGKTIKEKK IIAKYNEEEV VNLPLDLLCE 370 380 390 400 410 420 APLYDREAKE DLKEKEDDKE KIKMPEDLNA VLLKLLESPN ICSKEWIYQQ YDHEVQIRTI 430 440 450 460 470 480 IKPGKDAAVL RILETYPTGI ALTTDCNSRY CKLNPYVGAL NAVAEAVRNL ATVGAEPMAM 490 500 510 520 530 540 LDNLNFGNPE RAERFWQLAE CIKGLADAAE FFEIPVVGGN VSLYNETVIE GKEFPINPTP 550 560 570 580 590 600 AIFVLGKVED VEKVPGVLGN KIKDGDVLII TNETRDEMGG SEYYKVIHNT EEGIVPRVDL 610 620 630 640 650 660 EKEKKIYKEI REIIKEGLVS EAVDCSRGGL AIALAKMAVL NNIGLDVDLT SYNKNNLRDD 670 680 690 700 710 720 VLLFSETSGR IILAVREENK DKVLNKLSSA HVIGKVGGNR LKIKVNGRGI IDLDVNTMKK 730 RYYEAFPKMM GEL

References

[1]

"Complete sequence of chromosome of Methanocaldococcus vulcanius M7." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Lcollab F.I., Brettin T., Detter J.C., Han C., Tapia R., Kuske C.R., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Ovchinikova G., Sieprawska-Lupa M., Whitman W.B., Woyke T. Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700851 / DSM 12094 / M7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001787 Genomic DNA. Translation: ACX72543.1.
RefSeq	YP_003247025.1. NC_013407.1.
3D structure databases
ProteinModelPortal	C9RG41.
ModBase	Search...
Protein-protein interaction databases
STRING	C9RG41.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8513022.
GenomeReviews	Gene locus Metvu_0685 in contig CP001787_GR.
KEGG	mvu:Metvu_0685.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	YGNSFGV.
Family and domain databases
HAMAP	MF_00420. PurL_2. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR010074. PRibForGlyAmidine_synth_II. IPR016188. PurM_N-like. [Graphical view]
KO	K01952.
Pfam	PF00586. AIRS. 2 hits. PF02769. AIRS_C. 2 hits. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 2 hits. SSF55326. PurM_N-like. 2 hits.
TIGRFAMs	TIGR01736. FGAM_synth_II. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C9RG41_METVM

Accession

Primary (citable) accession number: C9RG41

Entry history

Integrated into UniProtKB/TrEMBL:	November 24, 2009
Last sequence update:	November 24, 2009
Last modified:	January 25, 2012
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)