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C9RG06 (C9RG06_METVM) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase HAMAP MF_00435
EC=1.1.1.86 HAMAP MF_00435
Alternative name(s):
Acetohydroxy-acid isomeroreductase HAMAP MF_00435
Alpha-keto-beta-hydroxylacil reductoisomerase HAMAP MF_00435
Gene names
Name:ilvC HAMAP MF_00435
Ordered Locus Names:Metvu_0649
OrganismMethanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius) [Complete proteome] [HAMAP]
Taxonomic identifier579137 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family. HAMAP MF_00435

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1081 By similarity HAMAP MF_00435

Sequences

Sequence LengthMass (Da)Tools
C9RG06 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: CCF43D81EC28AA58

FASTA33036,887
        10         20         30         40         50         60 
MVKIFYDKDV DFNAVKDKII AVIGYGSQGR AQALNMKDSG LNVVVGLRPN GSSWEKAKKD 

        70         80         90        100        110        120 
GHEVMSIEEA AEKADIIHIL IPDEVQPAVY KKQIEPYLTE GKTISFSHGY NIHYGFIKPP 

       130        140        150        160        170        180 
ENVNITMVAP KSPGAMVRKT YEEGFGVPGL VAVERDYTGD ALQIALGMAK GIGLTRVGVI 

       190        200        210        220        230        240 
QTTFKEETET DLFGEQVVLC GGVTELIKAA FETLVEAGYA PEMAYFETCH ELKLIVDLIY 

       250        260        270        280        290        300 
QKGLQGMWEN VSNTAEYGGL TRRERVINEE SRKAMKEILK EIQDGRFAKE WSLEREAGFP 

       310        320        330 
HLNALRRLEK EHLIEKVGKD LRKMCGLEKE

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References

[1]"Complete sequence of chromosome of Methanocaldococcus vulcanius M7."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Lcollab F.I., Brettin T., Detter J.C., Han C., Tapia R., Kuske C.R., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Ovchinikova G., Sieprawska-Lupa M., Whitman W.B., Woyke T.
Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700851 / DSM 12094 / M7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001787 Genomic DNA. Translation: ACX72508.1.
RefSeqYP_003246990.1. NC_013407.1.

3D structure databases

ProteinModelPortalC9RG06.
ModBaseSearch...

Protein-protein interaction databases

STRINGC9RG06.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8512983.
GenomeReviewsGene locus Metvu_0649 in contig CP001787_GR.
KEGGmvu:Metvu_0649.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAMAYAKGI.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
Gene3DG3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC9RG06_METVM
AccessionPrimary (citable) accession number: C9RG06
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: November 16, 2011
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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