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Protein

Proline--tRNA ligase

Gene

proS

Organism
Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).UniRule annotation

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
Alternative name(s):
Prolyl-tRNA synthetaseUniRule annotation
Short name:
ProRSUniRule annotation
Gene namesi
Name:proSUniRule annotation
Ordered Locus Names:Metvu_0171Imported
OrganismiMethanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)Imported
Taxonomic identifieri579137 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002063 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi579137.Metvu_0171

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 282AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST243

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili366 – 386Sequence analysisAdd BLAST21

Domaini

Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.UniRule annotation

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG00402 Archaea
COG0442 LUCA
HOGENOMiHOG000167538
KOiK01881
OMAiEVYWVTH
OrthoDBiPOG093Z01RZ

Family and domain databases

CDDicd00778 ProRS_core_arch_euk, 1 hit
Gene3Di3.30.110.30, 1 hit
3.40.50.800, 1 hit
HAMAPiMF_01571 Pro_tRNA_synth_type3, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR002316 Pro-tRNA-ligase_IIa
IPR004499 Pro-tRNA-ligase_IIa_arc-type
IPR017449 Pro-tRNA_synth_II
IPR015264 Pro-tRNA_synth_II_arc
IPR033721 ProRS_core_arch_euk
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF09181 ProRS-C_2, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PRINTSiPR01046 TRNASYNTHPRO
SUPFAMiSSF64586 SSF64586, 1 hit
TIGRFAMsiTIGR00408 proS_fam_I, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

C9REN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKINRGEIL DFSEWYSDIL EKAGIYDVRY PIKGCGVYLP YGFKIRRYAF
60 70 80 90 100
ELIRKLLDET GHDETLFPML IPEDLLAKEA EHIKGFEDEV YWVTHGGKTP
110 120 130 140 150
LDVKLALRPT SETPIYYMMR LWVKVHTDLP IKVYQIVNTF RYETKHTRPL
160 170 180 190 200
IRLREIMTFK EAHTAHSTKE EAEKQVEEAI SIYKKFFDVL GIPHLVSKRP
210 220 230 240 250
EWDKFPGAEY TMAFDTIFPD GRVMQIATVH NLGQNFSKTF EIIFETPTGD
260 270 280 290 300
KDFAYQTCYG ISDRVIASII AIHGDEKGLI LPPVVAPLQI VIVPLIFKGK
310 320 330 340 350
KEIVMEKSKE IYERLKDKYR VYIDDRDIRP GKKFYDWEIK GVPLRIEVGP
360 370 380 390 400
KDIESGKITI FRRDTMEKFQ VEDEQLEDEI EKTLNNIMEN IKNKAYRKFE
410 420 430 440 450
EYITMLEDVD LEKIRKILSE KRGVVLIPYK KEIYNEDLEE KVDATILGET
460
NYKGKKYIAI AKTY
Length:464
Mass (Da):54,389
Last modified:November 24, 2009 - v1
Checksum:iFAD0DA4FBAFEE3F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001787 Genomic DNA Translation: ACX72038.1

Genome annotation databases

EnsemblBacteriaiACX72038; ACX72038; Metvu_0171
KEGGimvu:Metvu_0171

Similar proteinsi

Entry informationi

Entry nameiC9REN6_METVM
AccessioniPrimary (citable) accession number: C9REN6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health