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Protein

Orotate phosphoribosyltransferase

Gene

pyrE

Organism
Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei905-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei915-phosphoribose 1-diphosphateUniRule annotation1
Binding sitei945-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei120OrotateUniRule annotation1
Binding sitei148OrotateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationImported, Transferase
Biological processPyrimidine biosynthesisUniRule annotation
LigandMagnesiumUniRule annotation

Enzyme and pathway databases

BioCyciMVUL579137:G1GGC-161-MONOMER
UniPathwayiUPA00070; UER00119

Names & Taxonomyi

Protein namesi
Recommended name:
Orotate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.10UniRule annotation)
Short name:
OPRTUniRule annotation
Short name:
OPRTaseUniRule annotation
Gene namesi
Name:pyrEUniRule annotation
Ordered Locus Names:Metvu_0163Imported
OrganismiMethanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)Imported
Taxonomic identifieri579137 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002063 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi579137.Metvu_0163

Structurei

3D structure databases

ProteinModelPortaliC9REM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 157PribosyltranInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 1245-phosphoribose 1-diphosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00029 Archaea
COG0461 LUCA
HOGENOMiHOG000037976
KOiK00762
OMAiMKAYQRQ
OrthoDBiPOG093Z0DC2

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00336 pyrE, 1 hit

Sequencei

Sequence statusi: Complete.

C9REM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCKNAELIKM LKEVGCIKFG DFVLSSGKRS DYYIDIKKAT TNPKVLKLVG
60 70 80 90 100
EMIADRIKDE NVKVAGVELG SVPIATAVSI ISQKPLLIVR KKAKDYGTKN
110 120 130 140 150
KIEGELNKGD RVVIVEDVTT TGGSVLKAVK EIRENGGIVD RVFVVVDRME
160 170
GARENLKKEG VELIPLVSVK ELRENL
Length:176
Mass (Da):19,354
Last modified:November 24, 2009 - v1
Checksum:i83668C0B184912E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001787 Genomic DNA Translation: ACX72030.1
RefSeqiWP_012819576.1, NC_013407.1

Genome annotation databases

EnsemblBacteriaiACX72030; ACX72030; Metvu_0163
GeneIDi8512491
KEGGimvu:Metvu_0163

Similar proteinsi

Entry informationi

Entry nameiC9REM8_METVM
AccessioniPrimary (citable) accession number: C9REM8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: February 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health