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Protein

Tetrahydromethanopterin S-methyltransferase subunit B

Gene

mtrB

Organism
Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.UniRule annotation

Catalytic activityi

5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na+(In) = 5,6,7,8-tetrahydromethanopterin + 2-(methylsulfanyl)ethane-1-sulfonate + 2 Na+(Out).UniRule annotation

Pathwayi: methanogenesis from CO(2)

This protein is involved in step 2 of the subpathway that synthesizes methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 5,10-methylenetetrahydromethanopterin reductase (mer)
  2. Tetrahydromethanopterin S-methyltransferase subunit G (mtrG), Tetrahydromethanopterin S-methyltransferase subunit H (mtrH), Tetrahydromethanopterin S-methyltransferase subunit A (mtrA), Tetrahydromethanopterin S-methyltransferase subunit F (mtrF), Tetrahydromethanopterin S-methyltransferase subunit B (mtrB), Tetrahydromethanopterin S-methyltransferase subunit D (mtrD), Tetrahydromethanopterin S-methyltransferase subunit C (mtrC), Tetrahydromethanopterin S-methyltransferase subunit E (mtrE)
This subpathway is part of the pathway methanogenesis from CO(2), which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin, the pathway methanogenesis from CO(2) and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseUniRule annotationImported, Transferase
Biological processMethanogenesisUniRule annotation, One-carbon metabolismUniRule annotation

Enzyme and pathway databases

BioCyciMVUL579137:G1GGC-151-MONOMER
UniPathwayiUPA00640; UER00698

Names & Taxonomyi

Protein namesi
Recommended name:
Tetrahydromethanopterin S-methyltransferase subunit BUniRule annotation (EC:2.1.1.86UniRule annotation)
Alternative name(s):
N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit BUniRule annotation
Gene namesi
Name:mtrBUniRule annotation
Ordered Locus Names:Metvu_0153Imported
OrganismiMethanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)Imported
Taxonomic identifieri579137 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002063 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei83 – 105HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.UniRule annotation

Protein-protein interaction databases

STRINGi579137.Metvu_0153

Family & Domainsi

Sequence similaritiesi

Belongs to the MtrB family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiarCOG04867 Archaea
COG4062 LUCA
HOGENOMiHOG000229675
KOiK00578
OMAiYFKSAFF
OrthoDBiPOG093Z0J8N

Family and domain databases

HAMAPiMF_01094 MtrB, 1 hit
InterProiView protein in InterPro
IPR008690 MtrB_MeTrfase
PfamiView protein in Pfam
PF05440 MtrB, 1 hit
PIRSFiPIRSF005518 MtrB, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012565 MtrB_MeTrfase, 1 hit
TIGRFAMsiTIGR04166 methano_MtrB, 1 hit

Sequencei

Sequence statusi: Complete.

C9REL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYVFIDLN IPLVYNVETG VITKGFGDIL YVDVAPIEEQ IKKLETLVDA
60 70 80 90 100
YEHSLDPRYP PLKSFPNRDG VYAMAGYFKS AFFGFWIGLG IMALLAIILG

VKILFKTLS
Length:109
Mass (Da):12,197
Last modified:November 24, 2009 - v1
Checksum:i94C3B26682812487
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001787 Genomic DNA Translation: ACX72021.1
RefSeqiWP_012819567.1, NC_013407.1

Genome annotation databases

EnsemblBacteriaiACX72021; ACX72021; Metvu_0153
GeneIDi8512481
KEGGimvu:Metvu_0153

Similar proteinsi

Entry informationi

Entry nameiC9REL9_METVM
AccessioniPrimary (citable) accession number: C9REL9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: February 28, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health