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Protein

Tetrahydromethanopterin S-methyltransferase subunit E

Gene

mtrE

Organism
Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.UniRule annotation

Catalytic activityi

5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na+(In) = 5,6,7,8-tetrahydromethanopterin + 2-(methylsulfanyl)ethane-1-sulfonate + 2 Na+(Out).UniRule annotation

Pathwayi: methanogenesis from CO(2)

This protein is involved in step 2 of the subpathway that synthesizes methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 5,10-methylenetetrahydromethanopterin reductase (mer)
  2. Tetrahydromethanopterin S-methyltransferase subunit G (mtrG), Tetrahydromethanopterin S-methyltransferase subunit H (mtrH), Tetrahydromethanopterin S-methyltransferase subunit A (mtrA), Tetrahydromethanopterin S-methyltransferase subunit F (mtrF), Tetrahydromethanopterin S-methyltransferase subunit B (mtrB), Tetrahydromethanopterin S-methyltransferase subunit D (mtrD), Tetrahydromethanopterin S-methyltransferase subunit C (mtrC), Tetrahydromethanopterin S-methyltransferase subunit E (mtrE)
This subpathway is part of the pathway methanogenesis from CO(2), which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin, the pathway methanogenesis from CO(2) and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseUniRule annotationImported, Transferase
Biological processMethanogenesisUniRule annotation, One-carbon metabolismUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00640; UER00698.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetrahydromethanopterin S-methyltransferase subunit EUniRule annotation (EC:2.1.1.86UniRule annotation)
Alternative name(s):
N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit EUniRule annotation
Gene namesi
Name:mtrEUniRule annotation
Ordered Locus Names:Metvu_0150Imported
OrganismiMethanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)Imported
Taxonomic identifieri579137 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002063 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei63 – 80HelicalUniRule annotationAdd BLAST18
Transmembranei87 – 110HelicalUniRule annotationAdd BLAST24
Transmembranei130 – 154HelicalUniRule annotationAdd BLAST25
Transmembranei227 – 246HelicalUniRule annotationAdd BLAST20
Transmembranei266 – 286HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.UniRule annotation

Protein-protein interaction databases

STRINGi579137.Metvu_0150.

Family & Domainsi

Sequence similaritiesi

Belongs to the MtrE family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiarCOG04870. Archaea.
COG4059. LUCA.
HOGENOMiHOG000229708.
KOiK00581.
OMAiVGSQSNP.
OrthoDBiPOG093Z081I.

Family and domain databases

HAMAPiMF_01098. MtrE. 1 hit.
InterProiView protein in InterPro
IPR005780. MeTrfase_E.
PfamiView protein in Pfam
PF04206. MtrE. 1 hit.
PIRSFiPIRSF016509. MtrE. 1 hit.
TIGRFAMsiTIGR01113. mtrE. 1 hit.

Sequencei

Sequence statusi: Complete.

C9REL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTTLIALGA LALSGALATV AGCAEDAESD VGSQSNPNSQ VQLAPQMGNI
60 70 80 90 100
HRYYNKAISG EPVSYGLFVA VAGSIAYALI QAGINPILAI ILGAGAAAFV
110 120 130 140 150
HGAYAVSAYL GRIVGQSKNF GQPVYWDVVM SHLGPIVGHG FIAVFCMVLM
160 170 180 190 200
AYLANTLLGD PFPLPLIAFI FGITVGAIGS STGDVHYGAE REYQKYPFGG
210 220 230 240 250
GVPVANHGDI DVEADYGIRN SMDSSYFCVR VGSVLTGLCF GLIVFLDGWR
260 270 280 290 300
GVLGNILGGL SGGSAINASI ISIVIGLIIV AAMAIINRKI EVFARNKFGP

YTK
Length:303
Mass (Da):31,470
Last modified:November 24, 2009 - v1
Checksum:i5AF121C89C60F4E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001787 Genomic DNA. Translation: ACX72018.1.
RefSeqiWP_012819564.1. NC_013407.1.

Genome annotation databases

EnsemblBacteriaiACX72018; ACX72018; Metvu_0150.
GeneIDi8512478.
KEGGimvu:Metvu_0150.

Similar proteinsi

Entry informationi

Entry nameiC9REL6_METVM
AccessioniPrimary (citable) accession number: C9REL6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: September 27, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported