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Protein

Putative archaetidylserine decarboxylase proenzyme

Gene

asd

Organism
Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).UniRule annotation

Catalytic activityi

Archaetidyl-L-serine = Archaetidylethanolamine + CO2.UniRule annotation

Cofactori

pyruvateUniRule annotationNote: Binds 1 pyruvoyl group covalently per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175Schiff-base intermediate with substrate; via pyruvic acidUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotation, Lyase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesisUniRule annotation, Phospholipid metabolism
LigandPyruvateUniRule annotation

Enzyme and pathway databases

BioCyciMVUL579137:G1GGC-116-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative archaetidylserine decarboxylase proenzymeUniRule annotation (EC:4.1.1.-UniRule annotation)
Cleaved into the following 2 chains:
Archaetidylserine decarboxylase alpha chainUniRule annotation
Archaetidylserine decarboxylase beta chainUniRule annotation
Gene namesi
Name:asdUniRule annotation
Ordered Locus Names:Metvu_0119Imported
OrganismiMethanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)Imported
Taxonomic identifieri579137 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175Pyruvic acid (Ser); by autocatalysisUniRule annotation1

Post-translational modificationi

Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei174 – 175Cleavage (non-hydrolytic); by autocatalysisUniRule annotation2

Keywords - PTMi

ZymogenUniRule annotation

Interactioni

Subunit structurei

Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.UniRule annotation

Protein-protein interaction databases

STRINGi579137.Metvu_0119

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04470 Archaea
COG0688 LUCA
HOGENOMiHOG000229359
KOiK01613
OMAiVSIFMSP
OrthoDBiPOG093Z0HMR

Family and domain databases

HAMAPiMF_00664 PS_decarb_PSD_A, 1 hit
InterProiView protein in InterPro
IPR003817 PS_Dcarbxylase
IPR033175 PSD-A
PANTHERiPTHR35809 PTHR35809, 1 hit
PfamiView protein in Pfam
PF02666 PS_Dcarbxylase, 1 hit
TIGRFAMsiTIGR00164 PS_decarb_rel, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C9REI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMDMKHKKF FAITVCSLLL FTVYFYRDPD RPITKGNNII LSPADGTIEY
60 70 80 90 100
INFYKSGNPE VFKDGNCYVV NVSKYFPNGC YVIGIFMSPL DVHVNRAPIG
110 120 130 140 150
GDVVYIKHIN GAFYPAFLSG VQKINERNIV IIKNGSEYVG VVQIAGFVAR
160 170 180 190 200
RCWLKIHEGE HVDMGERIGM IKLGSQTALI IPSDYNLKVK VGEKLYAGES
210
IVAIKKGENN
Length:210
Mass (Da):23,492
Last modified:November 24, 2009 - v1
Checksum:iE5E76FFE5BF10B36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001787 Genomic DNA Translation: ACX71987.1
RefSeqiWP_012819533.1, NC_013407.1

Genome annotation databases

EnsemblBacteriaiACX71987; ACX71987; Metvu_0119
GeneIDi8512445
KEGGimvu:Metvu_0119

Similar proteinsi

Entry informationi

Entry nameiC9REI5_METVM
AccessioniPrimary (citable) accession number: C9REI5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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