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Protein

DNA ligase

Gene

lig

Organism
Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei248ATPUniRule annotation1
Active sitei250N6-AMP-lysine intermediateUniRule annotation1
Binding sitei255ATPUniRule annotation1
Binding sitei270ATPUniRule annotation1
Binding sitei299ATPUniRule annotation1
Binding sitei340ATPUniRule annotation1
Binding sitei432ATPUniRule annotation1
Binding sitei438ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVUL579137:G1GGC-1667-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Metvu_1663Imported
OrganismiMethanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)Imported
Taxonomic identifieri579137 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002063 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi579137.Metvu_1663

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini328 – 473DNA_LIGASE_A3InterPro annotationAdd BLAST146

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

C9RDY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWKDVCEIF DKIENTTKRL EKRDYFIKLI DLVKEKGKPE DLKKICYMAI
60 70 80 90 100
GRVYPEYDER ELGIGEKLLI NAITSMGIKK EELLEKIKET GDIGFAVEQL
110 120 130 140 150
KSKTKQLSLL LSPLTVDDVY ETLKRVGEIE GEGSQKKKLR LISSLFMRAS
160 170 180 190 200
PIECRYLARL ILEDMRLGMN VPTILDALSV YFNVPKEKLE KIYAITNDIG
210 220 230 240 250
LLAEKLIKNE LESEDLKLKL FRPIKPMLAQ LAPSIEEALL EMGKAQFETK
260 270 280 290 300
YDGARVQIHK GGDKVKIYSR RLEDVTNALP EIVDAIKKIN VEELIVEGEC
310 320 330 340 350
VAIDKQTGKP RPFQDILRRF RRKYDIGKMM KEINLRVYLF DILYKNGTSL
360 370 380 390 400
IDEEFEKRRK ELEDIVGYEN DWRTERERIE RELKSDKIVD ISYKLVSDDP
410 420 430 440 450
KEAREFYNWS LSIGHEGVMI KNLKAPYTPG SRVRTMYKFK PTLESLDVVI
460 470 480 490 500
TKAKRGMGKR KDWYGSFEIC VKDEEGNLYP IGYVGTGLSE ADLEMLKEEI
510 520 530 540 550
DKIIKRDLGE EVEVEPKIVI EVAYEEIQKS DKYPCGYALR FPRVVRFRFD
560 570
KGKDDINTVK DVERIYEIQR GRK
Length:573
Mass (Da):66,685
Last modified:November 24, 2009 - v1
Checksum:i9C5FDFF9566B3945
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001787 Genomic DNA Translation: ACX73516.1
RefSeqiWP_015733734.1, NC_013407.1

Genome annotation databases

EnsemblBacteriaiACX73516; ACX73516; Metvu_1663
GeneIDi8514023
KEGGimvu:Metvu_1663

Similar proteinsi

Entry informationi

Entry nameiC9RDY7_METVM
AccessioniPrimary (citable) accession number: C9RDY7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: March 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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