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C9RDY7

- C9RDY7_METVM

UniProt

C9RDY7 - C9RDY7_METVM

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Protein

DNA ligase

Gene
lig, Metvu_1663
Organism
Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei248 – 2481ATP By similarityUniRule annotation
Active sitei250 – 2501N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei255 – 2551ATP By similarityUniRule annotation
Binding sitei270 – 2701ATP By similarityUniRule annotation
Binding sitei299 – 2991ATP By similarityUniRule annotation
Binding sitei340 – 3401ATP By similarityUniRule annotation
Binding sitei432 – 4321ATP By similarityUniRule annotation
Binding sitei438 – 4381ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVUL579137:GHFP-1697-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Metvu_1663Imported
OrganismiMethanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)Imported
Taxonomic identifieri579137 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000002063: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi579137.Metvu_1663.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9RDY7-1 [UniParc]FASTAAdd to Basket

« Hide

MLWKDVCEIF DKIENTTKRL EKRDYFIKLI DLVKEKGKPE DLKKICYMAI    50
GRVYPEYDER ELGIGEKLLI NAITSMGIKK EELLEKIKET GDIGFAVEQL 100
KSKTKQLSLL LSPLTVDDVY ETLKRVGEIE GEGSQKKKLR LISSLFMRAS 150
PIECRYLARL ILEDMRLGMN VPTILDALSV YFNVPKEKLE KIYAITNDIG 200
LLAEKLIKNE LESEDLKLKL FRPIKPMLAQ LAPSIEEALL EMGKAQFETK 250
YDGARVQIHK GGDKVKIYSR RLEDVTNALP EIVDAIKKIN VEELIVEGEC 300
VAIDKQTGKP RPFQDILRRF RRKYDIGKMM KEINLRVYLF DILYKNGTSL 350
IDEEFEKRRK ELEDIVGYEN DWRTERERIE RELKSDKIVD ISYKLVSDDP 400
KEAREFYNWS LSIGHEGVMI KNLKAPYTPG SRVRTMYKFK PTLESLDVVI 450
TKAKRGMGKR KDWYGSFEIC VKDEEGNLYP IGYVGTGLSE ADLEMLKEEI 500
DKIIKRDLGE EVEVEPKIVI EVAYEEIQKS DKYPCGYALR FPRVVRFRFD 550
KGKDDINTVK DVERIYEIQR GRK 573
Length:573
Mass (Da):66,685
Last modified:November 24, 2009 - v1
Checksum:i9C5FDFF9566B3945
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001787 Genomic DNA. Translation: ACX73516.1.
RefSeqiYP_003247998.1. NC_013407.1.

Genome annotation databases

EnsemblBacteriaiACX73516; ACX73516; Metvu_1663.
GeneIDi8514023.
KEGGimvu:Metvu_1663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001787 Genomic DNA. Translation: ACX73516.1 .
RefSeqi YP_003247998.1. NC_013407.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 579137.Metvu_1663.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACX73516 ; ACX73516 ; Metvu_1663 .
GeneIDi 8514023.
KEGGi mvu:Metvu_1663.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MVUL579137:GHFP-1697-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700851 / DSM 12094 / M7.

Entry informationi

Entry nameiC9RDY7_METVM
AccessioniPrimary (citable) accession number: C9RDY7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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