Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

C9RDA7 (C9RDA7_AMMDK) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Adeg_1108 EMBL ACX52234.1
OrganismAmmonifex degensii (strain DSM 10501 / KC4) [Complete proteome] [HAMAP] EMBL ACX52234.1
Taxonomic identifier429009 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupAmmonifex

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain99 – 301203ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding129 – 18456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2551Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2681Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2681Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2701Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C9RDA7 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 3307237EEA2F773F

FASTA30834,121
        10         20         30         40         50         60 
MRVAVLCGGN SAEREVSLRS GEAVYRALQE RGWEAVKIDV GPDIALRLSE VKPDVVFLAL 

        70         80         90        100        110        120 
HGKGGEDGSI QGLLEVMGLP YTGPGILASA LAMNKIATKR YLRSASLPTP DFITLDKEET 

       130        140        150        160        170        180 
HDEWLQRVKE FRPFPVVVKA PTQGSSLGMN IVRREEELLP ALAEAFRYDP VVLVEEFIEG 

       190        200        210        220        230        240 
VEVTAAVLGN RKPVVLPLIE IVADKGVYDY EAKYTPGKSQ HIIPPRLPEP WQEKVKELAL 

       250        260        270        280        290        300 
ATYRWLDCRG FSRIDFMVDH KGNPYILEVN TIPGLTEVSL FPDAARAAGI SFGELVERLI 


YLALGREE 

« Hide

References

[1]"Complete sequence of chromosome of Ammonifex degensii KC4."
US DOE Joint Genome Institute
Kerfeld C., Goodner B., Huber H., Stetter K., Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Ovchinnikova G., Richardson P.
Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 10501 / KC4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001785 Genomic DNA. Translation: ACX52234.1.
RefSeqYP_003239084.1. NC_013385.1.

3D structure databases

ProteinModelPortalC9RDA7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING429009.Adeg_1108.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACX52234; ACX52234; Adeg_1108.
GeneID8491096.
KEGGadg:Adeg_1108.
PATRIC20881782. VBIAmmDeg104956_1113.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycADEG429009:GHG1-1139-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC9RDA7_AMMDK
AccessionPrimary (citable) accession number: C9RDA7
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 11, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)