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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Ammonifex degensii (strain DSM 10501 / KC4)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi255Magnesium or manganese 1UniRule annotation1
Metal bindingi268Magnesium or manganese 1UniRule annotation1
Metal bindingi268Magnesium or manganese 2UniRule annotation1
Metal bindingi270Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Adeg_1108Imported
OrganismiAmmonifex degensii (strain DSM 10501 / KC4)Imported
Taxonomic identifieri429009 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupAmmonifex
Proteomesi
  • UP000002620 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi429009.Adeg_1108.

Structurei

3D structure databases

ProteinModelPortaliC9RDA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 301ATP-graspInterPro annotationAdd BLAST203

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF. Bacteria.
COG1181. LUCA.
HOGENOMiHOG000011592.
KOiK01921.
OrthoDBiPOG091H00GT.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 2 hits.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C9RDA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVAVLCGGN SAEREVSLRS GEAVYRALQE RGWEAVKIDV GPDIALRLSE
60 70 80 90 100
VKPDVVFLAL HGKGGEDGSI QGLLEVMGLP YTGPGILASA LAMNKIATKR
110 120 130 140 150
YLRSASLPTP DFITLDKEET HDEWLQRVKE FRPFPVVVKA PTQGSSLGMN
160 170 180 190 200
IVRREEELLP ALAEAFRYDP VVLVEEFIEG VEVTAAVLGN RKPVVLPLIE
210 220 230 240 250
IVADKGVYDY EAKYTPGKSQ HIIPPRLPEP WQEKVKELAL ATYRWLDCRG
260 270 280 290 300
FSRIDFMVDH KGNPYILEVN TIPGLTEVSL FPDAARAAGI SFGELVERLI

YLALGREE
Length:308
Mass (Da):34,121
Last modified:November 24, 2009 - v1
Checksum:i3307237EEA2F773F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001785 Genomic DNA. Translation: ACX52234.1.
RefSeqiWP_015739111.1. NC_013385.1.

Genome annotation databases

EnsemblBacteriaiACX52234; ACX52234; Adeg_1108.
KEGGiadg:Adeg_1108.

Similar proteinsi

Entry informationi

Entry nameiC9RDA7_AMMDK
AccessioniPrimary (citable) accession number: C9RDA7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: September 27, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported