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C9RB48 (C9RB48_AMMDK) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138
Ordered Locus Names:Adeg_0312
OrganismAmmonifex degensii (strain DSM 10501 / KC4) [Complete proteome] [HAMAP] EMBL ACX51475.1
Taxonomic identifier429009 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteraceae › Moorella group › Ammonifex ›

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds (magnesium or manganese,ion) per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain107 – 313207ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding133 – 19462ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2831Magnesium or manganese By similarity HAMAP-Rule MF_00138
Metal binding2851Magnesium or manganese By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
C9RB48 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 314FA407736B5ACA

FASTA42645,613
        10         20         30         40         50         60 
MRVLVVGGGG REHALVWKLA QSSRVEKLFC APGNAGIERL ATCVPIKATD LEGLLAFARQ 

        70         80         90        100        110        120 
EKIDLTVVGP EAPLAAGIVD LWEQAGLRIF GPSKQAAALE ASKVFAKKLM QRYGIPTARA 

       130        140        150        160        170        180 
AIFTSPEEAK AYVRSLETPC VVKADGLAAG KGVVVAATVE EAEKAIEDMM VRRVFGTAGE 

       190        200        210        220        230        240 
RVLIEEKLEG EEASVIALTD GKTVLPLLPA QDHKPVYDGD KGPNTGGMGA YAPAPMVDGA 

       250        260        270        280        290        300 
MLGRIQKEIL EPAVRGLASE GIVYRGALYA GLMLTREGPK VLEFNVRFGD PEAQPLLYLL 

       310        320        330        340        350        360 
ESDLLEALEA AIDGRLEDIK LSWYPGAAVC VVLAAAGYPG PARSGDEIKG LEELEEEEGI 

       370        380        390        400        410        420 
MVFHAGTRRE GDRLLTAGGR VLGVTARGKD VREARERAYK AVERISFPGM HFRRDIGLKA 


LKYLEG

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References

[1]"Complete sequence of chromosome of Ammonifex degensii KC4."
US DOE Joint Genome Institute
Kerfeld C., Goodner B., Huber H., Stetter K., Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Ovchinnikova G., Richardson P.
Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 10501 / KC4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001785 Genomic DNA. Translation: ACX51475.1.
RefSeqYP_003238325.1. NC_013385.1.

3D structure databases

ProteinModelPortalC9RB48.
ModBaseSearch...

Protein-protein interaction databases

STRING429009.Adeg_0312.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACX51475; ACX51475; Adeg_0312.
GeneID8490277.
KEGGadg:Adeg_0312.
PATRIC20880138. VBIAmmDeg104956_0312.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033464.
KOK01945.

Enzyme and pathway databases

BioCycADEG429009:GHG1-348-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC9RB48_AMMDK
AccessionPrimary (citable) accession number: C9RB48
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: May 1, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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