Skip Header

Contribute Send feedback
Read comments (?) or add your own

C9R908 (C9R908_AMMDK) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine--tRNA ligase HAMAP-Rule MF_02007
EC=6.1.1.1 HAMAP-Rule MF_02007
Alternative name(s):
Tyrosyl-tRNA synthetase HAMAP-Rule MF_02007
Gene names
Name:tyrS HAMAP-Rule MF_02007
Ordered Locus Names:Adeg_1695
OrganismAmmonifex degensii (strain DSM 10501 / KC4) [Complete proteome] [HAMAP] EMBL ACX52787.1
Taxonomic identifier429009 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteraceae › Moorella group › Ammonifex ›

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) By similarity. HAMAP-Rule MF_02007 SAAS SAAS002307

Catalytic activity

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). HAMAP-Rule MF_02007 SAAS SAAS002307

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_02007 SAAS SAAS002307

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_02007.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. HAMAP-Rule MF_02007

Contains 1 S4 RNA-binding domain. HAMAP-Rule MF_02007 SAAS SAAS002307

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain345 – 40561S4 RNA-binding By similarity HAMAP-Rule MF_02007
Motif46 – 5510"HIGH" region By similarity HAMAP-Rule MF_02007
Motif230 – 2345"KMSKS" region By similarity HAMAP-Rule MF_02007

Sites

Binding site2331ATP By similarity HAMAP-Rule MF_02007

Sequences

Sequence LengthMass (Da)Tools
C9R908 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 7C96BD629FECC3C4

FASTA40545,959
        10         20         30         40         50         60 
MKSVAEQLRL IKRGVAEIIT EEELVRKLER SLATGVPLNV KLGLDPTAPD IHLGHTVVLQ 

        70         80         90        100        110        120 
KLRHFQELGH RTIIVLGDFT ARIGDPTGKL ETRKQLSEEE VLANARTYKE QIFKVLDPEK 

       130        140        150        160        170        180 
TEIVFNSTWL APLTFAEVIK LAAHYTVARM LEREDFSKRF RAGLPISIHE FFYPLMQGYD 

       190        200        210        220        230        240 
SVVLRADVEL GGTDQRFNLL MGRTLQEAYG QEPQVAIMTP ILEGLDGVQK MSKSLGNYVG 

       250        260        270        280        290        300 
VTDPPEEMYG KLMSLPDELI ARYLRLVTDV PEEEIERIEQ EMKEGELNPR DAKMLLARTV 

       310        320        330        340        350        360 
VKRFHSEEAA AKAEEEFIRV FRHRELPSEI PEFPLPSELR EGGPIPLFRL LFLSGLVPSL 

       370        380        390        400 
SEARRLISQG GVRVNEEKIT DPQAPIKPRP GMVLRAGKRR FVRLV

« Hide

References

[1]"Complete sequence of chromosome of Ammonifex degensii KC4."
US DOE Joint Genome Institute
Kerfeld C., Goodner B., Huber H., Stetter K., Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Ovchinnikova G., Richardson P.
Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 10501 / KC4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001785 Genomic DNA. Translation: ACX52787.1.
RefSeqYP_003239637.1. NC_013385.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING429009.Adeg_1695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACX52787; ACX52787; Adeg_1695.
GeneID8491695.
KEGGadg:Adeg_1695.
PATRIC20882972. VBIAmmDeg104956_1698.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0162.
HOGENOMHOG000242791.
KOK01866.

Enzyme and pathway databases

BioCycADEG429009:GHG1-1766-MONOMER.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_02007. Tyr_tRNA_synth_type2.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002942. S4_RNA-bd.
IPR002307. Tyr-tRNA-ligase.
IPR024088. Tyr-tRNA-ligase_bac-type.
IPR024108. Tyr-tRNA-ligase_bac_2.
[Graphical view]
PANTHERPTHR11766. PTHR11766. 1 hit.
PfamPF01479. S4. 1 hit.
PF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01040. TRNASYNTHTYR.
SMARTSM00363. S4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00234. tyrS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC9R908_AMMDK
AccessionPrimary (citable) accession number: C9R908
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info