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C9R7B6

- APHA_AGGAD

UniProt

C9R7B6 - APHA_AGGAD

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Protein

Class B acid phosphatase

Gene
aphA, D11S_0149
Organism
Aggregatibacter actinomycetemcomitans serotype C (strain D11S-1) (Actinobacillus actinomycetemcomitans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds By similarity.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Binds 1 magnesium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Nucleophile By similarity
Metal bindingi67 – 671Magnesium By similarity
Active sitei69 – 691Proton donor By similarity
Metal bindingi69 – 691Magnesium; via carbonyl oxygen By similarity
Binding sitei175 – 1751Substrate By similarity
Metal bindingi190 – 1901Magnesium By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciAACT668336:GJBF-149-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Class B acid phosphatase (EC:3.1.3.2)
Short name:
CBAP
Gene namesi
Name:aphA
Ordered Locus Names:D11S_0149
OrganismiAggregatibacter actinomycetemcomitans serotype C (strain D11S-1) (Actinobacillus actinomycetemcomitans)
Taxonomic identifieri668336 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter
ProteomesiUP000002569: Chromosome

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 235213Class B acid phosphatasePRO_0000415224Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi668336.D11S_0149.

Structurei

3D structure databases

ProteinModelPortaliC9R7B6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni135 – 1362Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3700.
HOGENOMiHOG000270623.
KOiK03788.
OMAiPEFWEKM.
OrthoDBiEOG6HTNVZ.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR005519. Acid_phosphat_B.
IPR023214. HAD-like_dom.
IPR010025. HAD-SF_ppase_IIIB_AphA.
[Graphical view]
PfamiPF03767. Acid_phosphat_B. 1 hit.
[Graphical view]
PIRSFiPIRSF017818. Acid_Ptase_B. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01672. AphA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C9R7B6-1 [UniParc]FASTAAdd to Basket

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MKNLVKLSLI AMLTAATLPA MAAKSEPYTH QGTNAREMLV EQPIHWISVD    50
QLKKELEGKA PMNISFDIDE TVLFSSPCFY HGQQKYSPGK QDYLKNQDFW 100
NEVNAGCDQY SIPKQIAVDL INMHQERGDQ IYFITGRTAE DKDGVTPVLQ 150
KAFNIKNMHP VEFMGGRDRT TKYNKTPGII EHKVTIHYGD SDDDILAAKE 200
AGVRGIRLMR AANSTYQPMP TLGGYGEEVL INSSY 235
Length:235
Mass (Da):26,419
Last modified:November 24, 2009 - v1
Checksum:iE10606329006CD38
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001733 Genomic DNA. Translation: ACX81568.1.
RefSeqiWP_012820812.1. NC_013416.1.
YP_003254787.1. NC_013416.1.

Genome annotation databases

EnsemblBacteriaiACX81568; ACX81568; D11S_0149.
GeneIDi8535868.
KEGGiaat:D11S_0149.
PATRICi31911098. VBIAggAct139153_0138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001733 Genomic DNA. Translation: ACX81568.1 .
RefSeqi WP_012820812.1. NC_013416.1.
YP_003254787.1. NC_013416.1.

3D structure databases

ProteinModelPortali C9R7B6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 668336.D11S_0149.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACX81568 ; ACX81568 ; D11S_0149 .
GeneIDi 8535868.
KEGGi aat:D11S_0149.
PATRICi 31911098. VBIAggAct139153_0138.

Phylogenomic databases

eggNOGi COG3700.
HOGENOMi HOG000270623.
KOi K03788.
OMAi PEFWEKM.
OrthoDBi EOG6HTNVZ.

Enzyme and pathway databases

BioCyci AACT668336:GJBF-149-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR005519. Acid_phosphat_B.
IPR023214. HAD-like_dom.
IPR010025. HAD-SF_ppase_IIIB_AphA.
[Graphical view ]
Pfami PF03767. Acid_phosphat_B. 1 hit.
[Graphical view ]
PIRSFi PIRSF017818. Acid_Ptase_B. 1 hit.
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01672. AphA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aggregatibacter actinomycetemcomitans serotype c strain D11S-1."
    Chen C., Kittichotirat W., Si Y., Bumgarner R.
    J. Bacteriol. 191:7378-7379(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D11S-1.

Entry informationi

Entry nameiAPHA_AGGAD
AccessioniPrimary (citable) accession number: C9R7B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: November 24, 2009
Last modified: September 3, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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