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C9R7B6

- APHA_AGGAD

UniProt

C9R7B6 - APHA_AGGAD

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Protein
Class B acid phosphatase
Gene
aphA, D11S_0149
Organism
Aggregatibacter actinomycetemcomitans serotype C (strain D11S-1) (Actinobacillus actinomycetemcomitans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds By similarity.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Binds 1 magnesium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Nucleophile By similarity
Metal bindingi67 – 671Magnesium By similarity
Active sitei69 – 691Proton donor By similarity
Metal bindingi69 – 691Magnesium; via carbonyl oxygen By similarity
Binding sitei175 – 1751Substrate By similarity
Metal bindingi190 – 1901Magnesium By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciAACT668336:GJBF-149-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Class B acid phosphatase (EC:3.1.3.2)
    Short name:
    CBAP
    Gene namesi
    Name:aphA
    Ordered Locus Names:D11S_0149
    OrganismiAggregatibacter actinomycetemcomitans serotype C (strain D11S-1) (Actinobacillus actinomycetemcomitans)
    Taxonomic identifieri668336 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter
    ProteomesiUP000002569: Chromosome

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro
    Complete GO annotation...

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222 Reviewed prediction
    Add
    BLAST
    Chaini23 – 235213Class B acid phosphatase
    PRO_0000415224Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer By similarity.

    Protein-protein interaction databases

    STRINGi668336.D11S_0149.

    Structurei

    3D structure databases

    ProteinModelPortaliC9R7B6.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni135 – 1362Substrate binding By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3700.
    HOGENOMiHOG000270623.
    KOiK03788.
    OMAiPEFWEKM.
    OrthoDBiEOG6HTNVZ.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR005519. Acid_phosphat_B.
    IPR023214. HAD-like_dom.
    IPR010025. HAD-SF_ppase_IIIB_AphA.
    [Graphical view]
    PfamiPF03767. Acid_phosphat_B. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017818. Acid_Ptase_B. 1 hit.
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01672. AphA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C9R7B6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNLVKLSLI AMLTAATLPA MAAKSEPYTH QGTNAREMLV EQPIHWISVD    50
    QLKKELEGKA PMNISFDIDE TVLFSSPCFY HGQQKYSPGK QDYLKNQDFW 100
    NEVNAGCDQY SIPKQIAVDL INMHQERGDQ IYFITGRTAE DKDGVTPVLQ 150
    KAFNIKNMHP VEFMGGRDRT TKYNKTPGII EHKVTIHYGD SDDDILAAKE 200
    AGVRGIRLMR AANSTYQPMP TLGGYGEEVL INSSY 235
    Length:235
    Mass (Da):26,419
    Last modified:November 24, 2009 - v1
    Checksum:iE10606329006CD38
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001733 Genomic DNA. Translation: ACX81568.1.
    RefSeqiWP_012820812.1. NC_013416.1.
    YP_003254787.1. NC_013416.1.

    Genome annotation databases

    EnsemblBacteriaiACX81568; ACX81568; D11S_0149.
    GeneIDi8535868.
    KEGGiaat:D11S_0149.
    PATRICi31911098. VBIAggAct139153_0138.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001733 Genomic DNA. Translation: ACX81568.1 .
    RefSeqi WP_012820812.1. NC_013416.1.
    YP_003254787.1. NC_013416.1.

    3D structure databases

    ProteinModelPortali C9R7B6.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 668336.D11S_0149.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACX81568 ; ACX81568 ; D11S_0149 .
    GeneIDi 8535868.
    KEGGi aat:D11S_0149.
    PATRICi 31911098. VBIAggAct139153_0138.

    Phylogenomic databases

    eggNOGi COG3700.
    HOGENOMi HOG000270623.
    KOi K03788.
    OMAi PEFWEKM.
    OrthoDBi EOG6HTNVZ.

    Enzyme and pathway databases

    BioCyci AACT668336:GJBF-149-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR005519. Acid_phosphat_B.
    IPR023214. HAD-like_dom.
    IPR010025. HAD-SF_ppase_IIIB_AphA.
    [Graphical view ]
    Pfami PF03767. Acid_phosphat_B. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017818. Acid_Ptase_B. 1 hit.
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01672. AphA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Aggregatibacter actinomycetemcomitans serotype c strain D11S-1."
      Chen C., Kittichotirat W., Si Y., Bumgarner R.
      J. Bacteriol. 191:7378-7379(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D11S-1.

    Entry informationi

    Entry nameiAPHA_AGGAD
    AccessioniPrimary (citable) accession number: C9R7B6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: November 24, 2009
    Last modified: September 3, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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