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C9R7B6 (APHA_AGGAD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Class B acid phosphatase

Short name=CBAP
EC=3.1.3.2
Gene names
Name:aphA
Ordered Locus Names:D11S_0149
OrganismAggregatibacter actinomycetemcomitans serotype C (strain D11S-1) (Actinobacillus actinomycetemcomitans) [Complete proteome] [HAMAP]
Taxonomic identifier668336 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds By similarity.

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Periplasm By similarity.

Sequence similarities

Belongs to the class B bacterial acid phosphatase family.

Ontologies

Keywords
   Cellular componentPeriplasm
   DomainSignal
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentouter membrane-bounded periplasmic space

Inferred from electronic annotation. Source: InterPro

   Molecular_functionacid phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 235213Class B acid phosphatase
PRO_0000415224

Regions

Region135 – 1362Substrate binding By similarity

Sites

Active site671Nucleophile By similarity
Active site691Proton donor By similarity
Metal binding671Magnesium By similarity
Metal binding691Magnesium; via carbonyl oxygen By similarity
Metal binding1901Magnesium By similarity
Binding site1751Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
C9R7B6 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: E10606329006CD38

FASTA23526,419
        10         20         30         40         50         60 
MKNLVKLSLI AMLTAATLPA MAAKSEPYTH QGTNAREMLV EQPIHWISVD QLKKELEGKA 

        70         80         90        100        110        120 
PMNISFDIDE TVLFSSPCFY HGQQKYSPGK QDYLKNQDFW NEVNAGCDQY SIPKQIAVDL 

       130        140        150        160        170        180 
INMHQERGDQ IYFITGRTAE DKDGVTPVLQ KAFNIKNMHP VEFMGGRDRT TKYNKTPGII 

       190        200        210        220        230 
EHKVTIHYGD SDDDILAAKE AGVRGIRLMR AANSTYQPMP TLGGYGEEVL INSSY 

« Hide

References

[1]"Genome sequence of Aggregatibacter actinomycetemcomitans serotype c strain D11S-1."
Chen C., Kittichotirat W., Si Y., Bumgarner R.
J. Bacteriol. 191:7378-7379(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D11S-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001733 Genomic DNA. Translation: ACX81568.1.
RefSeqYP_003254787.1. NC_013416.1.

3D structure databases

ProteinModelPortalC9R7B6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING668336.D11S_0149.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACX81568; ACX81568; D11S_0149.
GeneID8535868.
KEGGaat:D11S_0149.
PATRIC31911098. VBIAggAct139153_0138.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3700.
HOGENOMHOG000270623.
KOK03788.
OMAPEFWEKM.
OrthoDBEOG6HTNVZ.

Enzyme and pathway databases

BioCycAACT668336:GJBF-149-MONOMER.

Family and domain databases

Gene3D3.40.50.1000. 1 hit.
InterProIPR005519. Acid_phosphat_B.
IPR023214. HAD-like_dom.
IPR010025. HAD-SF_ppase_IIIB_AphA.
[Graphical view]
PfamPF03767. Acid_phosphat_B. 1 hit.
[Graphical view]
PIRSFPIRSF017818. Acid_Ptase_B. 1 hit.
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01672. AphA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAPHA_AGGAD
AccessionPrimary (citable) accession number: C9R7B6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: November 24, 2009
Last modified: April 16, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families