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C9R7B6

- APHA_AGGAD

UniProt

C9R7B6 - APHA_AGGAD

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Protein

Class B acid phosphatase

Gene

aphA

Organism
Aggregatibacter actinomycetemcomitans serotype C (strain D11S-1) (Actinobacillus actinomycetemcomitans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds (By similarity).By similarity

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671NucleophileBy similarity
Metal bindingi67 – 671MagnesiumBy similarity
Active sitei69 – 691Proton donorBy similarity
Metal bindingi69 – 691Magnesium; via carbonyl oxygenBy similarity
Binding sitei175 – 1751SubstrateBy similarity
Metal bindingi190 – 1901MagnesiumBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciAACT668336:GJBF-149-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Class B acid phosphataseBy similarity (EC:3.1.3.2By similarity)
Short name:
CBAPBy similarity
Gene namesi
Name:aphABy similarity
Ordered Locus Names:D11S_0149
OrganismiAggregatibacter actinomycetemcomitans serotype C (strain D11S-1) (Actinobacillus actinomycetemcomitans)
Taxonomic identifieri668336 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter
ProteomesiUP000002569: Chromosome

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 235213Class B acid phosphataseSequence AnalysisPRO_0000415224Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi668336.D11S_0149.

Structurei

3D structure databases

ProteinModelPortaliC9R7B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni135 – 1362Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class B bacterial acid phosphatase family.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3700.
HOGENOMiHOG000270623.
KOiK03788.
OMAiPEFWEKM.
OrthoDBiEOG6HTNVZ.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR005519. Acid_phosphat_B.
IPR023214. HAD-like_dom.
IPR010025. HAD-SF_ppase_IIIB_AphA.
[Graphical view]
PfamiPF03767. Acid_phosphat_B. 1 hit.
[Graphical view]
PIRSFiPIRSF017818. Acid_Ptase_B. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01672. AphA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C9R7B6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNLVKLSLI AMLTAATLPA MAAKSEPYTH QGTNAREMLV EQPIHWISVD
60 70 80 90 100
QLKKELEGKA PMNISFDIDE TVLFSSPCFY HGQQKYSPGK QDYLKNQDFW
110 120 130 140 150
NEVNAGCDQY SIPKQIAVDL INMHQERGDQ IYFITGRTAE DKDGVTPVLQ
160 170 180 190 200
KAFNIKNMHP VEFMGGRDRT TKYNKTPGII EHKVTIHYGD SDDDILAAKE
210 220 230
AGVRGIRLMR AANSTYQPMP TLGGYGEEVL INSSY
Length:235
Mass (Da):26,419
Last modified:November 24, 2009 - v1
Checksum:iE10606329006CD38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001733 Genomic DNA. Translation: ACX81568.1.
RefSeqiWP_012820812.1. NC_013416.1.
YP_003254787.1. NC_013416.1.

Genome annotation databases

EnsemblBacteriaiACX81568; ACX81568; D11S_0149.
GeneIDi8535868.
KEGGiaat:D11S_0149.
PATRICi31911098. VBIAggAct139153_0138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001733 Genomic DNA. Translation: ACX81568.1 .
RefSeqi WP_012820812.1. NC_013416.1.
YP_003254787.1. NC_013416.1.

3D structure databases

ProteinModelPortali C9R7B6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 668336.D11S_0149.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACX81568 ; ACX81568 ; D11S_0149 .
GeneIDi 8535868.
KEGGi aat:D11S_0149.
PATRICi 31911098. VBIAggAct139153_0138.

Phylogenomic databases

eggNOGi COG3700.
HOGENOMi HOG000270623.
KOi K03788.
OMAi PEFWEKM.
OrthoDBi EOG6HTNVZ.

Enzyme and pathway databases

BioCyci AACT668336:GJBF-149-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR005519. Acid_phosphat_B.
IPR023214. HAD-like_dom.
IPR010025. HAD-SF_ppase_IIIB_AphA.
[Graphical view ]
Pfami PF03767. Acid_phosphat_B. 1 hit.
[Graphical view ]
PIRSFi PIRSF017818. Acid_Ptase_B. 1 hit.
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01672. AphA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aggregatibacter actinomycetemcomitans serotype c strain D11S-1."
    Chen C., Kittichotirat W., Si Y., Bumgarner R.
    J. Bacteriol. 191:7378-7379(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D11S-11 Publication.

Entry informationi

Entry nameiAPHA_AGGAD
AccessioniPrimary (citable) accession number: C9R7B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: November 24, 2009
Last modified: November 26, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3