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C9R7B6

- APHA_AGGAD

UniProt

C9R7B6 - APHA_AGGAD

Protein

Class B acid phosphatase

Gene

aphA

Organism
Aggregatibacter actinomycetemcomitans serotype C (strain D11S-1) (Actinobacillus actinomycetemcomitans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds By similarity.By similarity

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.By similarity

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei67 – 671NucleophileBy similarity
    Metal bindingi67 – 671MagnesiumBy similarity
    Active sitei69 – 691Proton donorBy similarity
    Metal bindingi69 – 691Magnesium; via carbonyl oxygenBy similarity
    Binding sitei175 – 1751SubstrateBy similarity
    Metal bindingi190 – 1901MagnesiumBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciAACT668336:GJBF-149-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Class B acid phosphataseBy similarity (EC:3.1.3.2By similarity)
    Short name:
    CBAPBy similarity
    Gene namesi
    Name:aphABy similarity
    Ordered Locus Names:D11S_0149
    OrganismiAggregatibacter actinomycetemcomitans serotype C (strain D11S-1) (Actinobacillus actinomycetemcomitans)
    Taxonomic identifieri668336 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter
    ProteomesiUP000002569: Chromosome

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 235213Class B acid phosphataseSequence AnalysisPRO_0000415224Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi668336.D11S_0149.

    Structurei

    3D structure databases

    ProteinModelPortaliC9R7B6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni135 – 1362Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class B bacterial acid phosphatase family.By similarity

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3700.
    HOGENOMiHOG000270623.
    KOiK03788.
    OMAiPEFWEKM.
    OrthoDBiEOG6HTNVZ.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR005519. Acid_phosphat_B.
    IPR023214. HAD-like_dom.
    IPR010025. HAD-SF_ppase_IIIB_AphA.
    [Graphical view]
    PfamiPF03767. Acid_phosphat_B. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017818. Acid_Ptase_B. 1 hit.
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01672. AphA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C9R7B6-1 [UniParc]FASTAAdd to Basket

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    MKNLVKLSLI AMLTAATLPA MAAKSEPYTH QGTNAREMLV EQPIHWISVD    50
    QLKKELEGKA PMNISFDIDE TVLFSSPCFY HGQQKYSPGK QDYLKNQDFW 100
    NEVNAGCDQY SIPKQIAVDL INMHQERGDQ IYFITGRTAE DKDGVTPVLQ 150
    KAFNIKNMHP VEFMGGRDRT TKYNKTPGII EHKVTIHYGD SDDDILAAKE 200
    AGVRGIRLMR AANSTYQPMP TLGGYGEEVL INSSY 235
    Length:235
    Mass (Da):26,419
    Last modified:November 24, 2009 - v1
    Checksum:iE10606329006CD38
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001733 Genomic DNA. Translation: ACX81568.1.
    RefSeqiWP_012820812.1. NC_013416.1.
    YP_003254787.1. NC_013416.1.

    Genome annotation databases

    EnsemblBacteriaiACX81568; ACX81568; D11S_0149.
    GeneIDi8535868.
    KEGGiaat:D11S_0149.
    PATRICi31911098. VBIAggAct139153_0138.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001733 Genomic DNA. Translation: ACX81568.1 .
    RefSeqi WP_012820812.1. NC_013416.1.
    YP_003254787.1. NC_013416.1.

    3D structure databases

    ProteinModelPortali C9R7B6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 668336.D11S_0149.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACX81568 ; ACX81568 ; D11S_0149 .
    GeneIDi 8535868.
    KEGGi aat:D11S_0149.
    PATRICi 31911098. VBIAggAct139153_0138.

    Phylogenomic databases

    eggNOGi COG3700.
    HOGENOMi HOG000270623.
    KOi K03788.
    OMAi PEFWEKM.
    OrthoDBi EOG6HTNVZ.

    Enzyme and pathway databases

    BioCyci AACT668336:GJBF-149-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR005519. Acid_phosphat_B.
    IPR023214. HAD-like_dom.
    IPR010025. HAD-SF_ppase_IIIB_AphA.
    [Graphical view ]
    Pfami PF03767. Acid_phosphat_B. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017818. Acid_Ptase_B. 1 hit.
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01672. AphA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Aggregatibacter actinomycetemcomitans serotype c strain D11S-1."
      Chen C., Kittichotirat W., Si Y., Bumgarner R.
      J. Bacteriol. 191:7378-7379(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D11S-11 Publication.

    Entry informationi

    Entry nameiAPHA_AGGAD
    AccessioniPrimary (citable) accession number: C9R7B6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3