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Protein

Class B acid phosphatase

Gene

aphA

Organism
Aggregatibacter actinomycetemcomitans serotype C (strain D11S-1) (Actinobacillus actinomycetemcomitans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds (By similarity).By similarity

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67NucleophileBy similarity1
Metal bindingi67MagnesiumBy similarity1
Active sitei69Proton donorBy similarity1
Metal bindingi69Magnesium; via carbonyl oxygenBy similarity1
Binding sitei175SubstrateBy similarity1
Metal bindingi190MagnesiumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciAACT668336:GJBF-149-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Class B acid phosphataseBy similarity (EC:3.1.3.2By similarity)
Short name:
CBAPBy similarity
Gene namesi
Name:aphABy similarity
Ordered Locus Names:D11S_0149
OrganismiAggregatibacter actinomycetemcomitans serotype C (strain D11S-1) (Actinobacillus actinomycetemcomitans)
Taxonomic identifieri668336 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter
Proteomesi
  • UP000002569 Componenti: Chromosome

Subcellular locationi

  • Periplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000041522423 – 235Class B acid phosphataseSequence analysisAdd BLAST213

Proteomic databases

PRIDEiC9R7B6.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliC9R7B6.
SMRiC9R7B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 136Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the class B bacterial acid phosphatase family.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000270623.
KOiK03788.
OMAiPEFWEKM.

Family and domain databases

CDDicd07499. HAD_CBAP. 1 hit.
Gene3Di3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR005519. Acid_phosphat_B-like.
IPR023214. HAD-like_dom.
IPR010025. HAD-SF_ppase_IIIB_AphA.
PfamiView protein in Pfam
PF03767. Acid_phosphat_B. 1 hit.
PIRSFiPIRSF017818. Acid_Ptase_B. 1 hit.
SFLDiSFLDG01127. C1.3:_Acid_Phosphatase_Like. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01672. AphA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C9R7B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNLVKLSLI AMLTAATLPA MAAKSEPYTH QGTNAREMLV EQPIHWISVD
60 70 80 90 100
QLKKELEGKA PMNISFDIDE TVLFSSPCFY HGQQKYSPGK QDYLKNQDFW
110 120 130 140 150
NEVNAGCDQY SIPKQIAVDL INMHQERGDQ IYFITGRTAE DKDGVTPVLQ
160 170 180 190 200
KAFNIKNMHP VEFMGGRDRT TKYNKTPGII EHKVTIHYGD SDDDILAAKE
210 220 230
AGVRGIRLMR AANSTYQPMP TLGGYGEEVL INSSY
Length:235
Mass (Da):26,419
Last modified:November 24, 2009 - v1
Checksum:iE10606329006CD38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001733 Genomic DNA. Translation: ACX81568.1.

Genome annotation databases

EnsemblBacteriaiACX81568; ACX81568; D11S_0149.
KEGGiaat:D11S_0149.
PATRICifig|668336.12.peg.144.

Similar proteinsi

Entry informationi

Entry nameiAPHA_AGGAD
AccessioniPrimary (citable) accession number: C9R7B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: November 24, 2009
Last modified: August 30, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families