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Protein

DNA mismatch repair protein MutH

Gene

mutH

Organism
Aggregatibacter actinomycetemcomitans serotype C (strain D11S-1) (Actinobacillus actinomycetemcomitans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repairUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAACT668336:GJBF-1481-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutHUniRule annotationSAAS annotation
Alternative name(s):
Methyl-directed mismatch repair proteinUniRule annotation
Gene namesi
Name:mutHUniRule annotation
Ordered Locus Names:D11S_1483Imported
OrganismiAggregatibacter actinomycetemcomitans serotype C (strain D11S-1) (Actinobacillus actinomycetemcomitans)Imported
Taxonomic identifieri668336 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter
ProteomesiUP000002569 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the MutH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3066.
HOGENOMiHOG000271839.
KOiK03573.
OMAiLRPKGAN.
OrthoDBiEOG6CGCC0.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

C9R4X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPQTTEALL SRAQSIAGLT FGELAAQWHI SVPPNLKRDK GWVGMLLETA
60 70 80 90 100
LGATAGSKAE QDFTHLGIEL KTLPINEQGY PLETTFVSLA PLIQNSGVNW
110 120 130 140 150
QNSHVRHKLS RVLWIPIEGS RHIPLAERHI GTPILWQPNE QQEALLKQDW
160 170 180 190 200
EELMDYIVLG QLDKINARLG EVLQLRPKAA NSKALTKGIG KNGEIIDTLP
210 220
LGFYLRKEFT YQILQQFVQQ AI
Length:222
Mass (Da):24,887
Last modified:November 24, 2009 - v1
Checksum:i991A798139F14934
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001733 Genomic DNA. Translation: ACX82859.1.
RefSeqiWP_005541016.1. NC_013416.1.
YP_003256078.1. NC_013416.1.

Genome annotation databases

EnsemblBacteriaiACX82859; ACX82859; D11S_1483.
GeneIDi8537202.
KEGGiaat:D11S_1483.
PATRICi31913701. VBIAggAct139153_1395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001733 Genomic DNA. Translation: ACX82859.1.
RefSeqiWP_005541016.1. NC_013416.1.
YP_003256078.1. NC_013416.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX82859; ACX82859; D11S_1483.
GeneIDi8537202.
KEGGiaat:D11S_1483.
PATRICi31913701. VBIAggAct139153_1395.

Phylogenomic databases

eggNOGiCOG3066.
HOGENOMiHOG000271839.
KOiK03573.
OMAiLRPKGAN.
OrthoDBiEOG6CGCC0.

Enzyme and pathway databases

BioCyciAACT668336:GJBF-1481-MONOMER.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Aggregatibacter actinomycetemcomitans serotype c strain D11S-1."
    Chen C., Kittichotirat W., Si Y., Bumgarner R.
    J. Bacteriol. 191:7378-7379(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D11S-1Imported.

Entry informationi

Entry nameiC9R4X3_AGGAD
AccessioniPrimary (citable) accession number: C9R4X3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 24, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.