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C9QXW2

- C9QXW2_ECOD1

UniProt

C9QXW2 - C9QXW2_ECOD1

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Protein

Thymidine kinase

Gene

tdk

Organism
Escherichia coli (strain ATCC 33849 / DSM 4235 / NCIB 12045 / K12 / DH1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptorUniRule annotation
Metal bindingi145 – 1451ZincUniRule annotation
Metal bindingi147 – 1471ZincUniRule annotation
Metal bindingi182 – 1821ZincUniRule annotation
Metal bindingi185 – 1851ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi87 – 904ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:EcDH1_2411Imported, ECDH1ME8569_1176Imported
OrganismiEscherichia coli (strain ATCC 33849 / DSM 4235 / NCIB 12045 / K12 / DH1)Imported
Taxonomic identifieri536056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000002619: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliC9QXW2.
SMRiC9QXW2. Positions 6-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9QXW2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLYFYYSA MNAGKSTALL QSSYNYQERG MRTVVYTAEI DDRFGAGKVS
60 70 80 90 100
SRIGLSSPAK LFNQNSSLFD EIRAEHEQQA IHCVLVDECQ FLTRQQVYEL
110 120 130 140 150
SEVVDQLDIP VLCYGLRTDF RGELFIGSQY LLAWSDKLVE LKTICFCGRK
160 170 180 190 200
ASMVLRLDQA GRPYNEGEQV VIGGNERYVS VCRKHYKEAL QVDSLTAIQE

RHRHD
Length:205
Mass (Da):23,457
Last modified:November 24, 2009 - v1
Checksum:i533166D9EAD20E16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001637 Genomic DNA. Translation: ACX40053.1.
AP012030 Genomic DNA. Translation: BAJ43032.1.
RefSeqiYP_006092342.1. NC_017625.1.
YP_006128577.1. NC_017638.1.

Genome annotation databases

EnsemblBacteriaiACX40053; ACX40053; EcDH1_2411.
BAJ43032; BAJ43032; ECDH1ME8569_1176.
GeneIDi12706014.
12872692.
KEGGiedh:EcDH1_2411.
edj:ECDH1ME8569_1176.
PATRICi36697142. VBIEscCol36761_2538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001637 Genomic DNA. Translation: ACX40053.1 .
AP012030 Genomic DNA. Translation: BAJ43032.1 .
RefSeqi YP_006092342.1. NC_017625.1.
YP_006128577.1. NC_017638.1.

3D structure databases

ProteinModelPortali C9QXW2.
SMRi C9QXW2. Positions 6-187.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACX40053 ; ACX40053 ; EcDH1_2411 .
BAJ43032 ; BAJ43032 ; ECDH1ME8569_1176 .
GeneIDi 12706014.
12872692.
KEGGi edh:EcDH1_2411.
edj:ECDH1ME8569_1176.
PATRICi 36697142. VBIEscCol36761_2538.

Phylogenomic databases

HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33849 / DSM 4235 / NCIB 12045 / K12 / DH1Imported and DH1Imported.
  2. "Comparison of sequence reads obtained from three next-generation sequencing platforms."
    Suzuki S., Ono N., Furusawa C., Ying B.-W., Yomo T.
    PLoS ONE 6:E19534-E19534(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DH1Imported.

Entry informationi

Entry nameiC9QXW2_ECOD1
AccessioniPrimary (citable) accession number: C9QXW2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3