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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Escherichia coli (strain ATCC 33849 / DSM 4235 / NCIB 12045 / K12 / DH1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sodCImported
Ordered Locus Names:EcDH1_1994Imported, ECDH1ME8569_1590Imported
OrganismiEscherichia coli (strain ATCC 33849 / DSM 4235 / NCIB 12045 / K12 / DH1)Imported
Taxonomic identifieri536056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000004998 Componenti: Chromosome UP000002619 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 PotentialImportedAdd
BLAST
Chaini21 – 173153 PotentialImportedPRO_5000524148Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC9QUT7.
SMRiC9QUT7. Positions 20-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

HOGENOMiHOG000263449.
OMAiGARYACG.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C9QUT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRFSLAILA LVVATGAQAA SEKVEMNLVT SQGVGQSIGS VTITETDKGL
60 70 80 90 100
EFSPDLKALP PGEHGFHIHA KGSCQPATKD GKASAAESAG GHLDPQNTGK
110 120 130 140 150
HEGPEGAGHL GDLPALVVNN DGKATDAVIA PRLKSLDEIK DKALMVHVGG
160 170
DNMSDQPKPL GGGGERYACG VIK
Length:173
Mass (Da):17,681
Last modified:November 24, 2009 - v1
Checksum:i9A0CB65F03AAB197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001637 Genomic DNA. Translation: ACX39651.1.
AP012030 Genomic DNA. Translation: BAJ43446.1.
RefSeqiYP_006091940.1. NC_017625.1.
YP_006128991.1. NC_017638.1.

Genome annotation databases

EnsemblBacteriaiACX39651; ACX39651; EcDH1_1994.
BAJ43446; BAJ43446; ECDH1ME8569_1590.
KEGGiedh:EcDH1_1994.
edj:ECDH1ME8569_1590.
PATRICi36696282. VBIEscCol36761_2108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001637 Genomic DNA. Translation: ACX39651.1.
AP012030 Genomic DNA. Translation: BAJ43446.1.
RefSeqiYP_006091940.1. NC_017625.1.
YP_006128991.1. NC_017638.1.

3D structure databases

ProteinModelPortaliC9QUT7.
SMRiC9QUT7. Positions 20-173.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX39651; ACX39651; EcDH1_1994.
BAJ43446; BAJ43446; ECDH1ME8569_1590.
KEGGiedh:EcDH1_1994.
edj:ECDH1ME8569_1590.
PATRICi36696282. VBIEscCol36761_2108.

Phylogenomic databases

HOGENOMiHOG000263449.
OMAiGARYACG.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33849 / DSM 4235 / NCIB 12045 / K12 / DH1Imported and DH1Imported.
  2. "Comparison of sequence reads obtained from three next-generation sequencing platforms."
    Suzuki S., Ono N., Furusawa C., Ying B.-W., Yomo T.
    PLoS ONE 6:E19534-E19534(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DH1Imported.

Entry informationi

Entry nameiC9QUT7_ECOD1
AccessioniPrimary (citable) accession number: C9QUT7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: April 1, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.