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C9LYV0 (C9LYV0_SELS3) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP-Rule MF_01897
EC=5.99.1.3 HAMAP-Rule MF_01897
Gene names
Name:gyrA HAMAP-Rule MF_01897
ORF Names:Selsp_1983 EMBL AEC00933.1, SELSPUOL_02661 EMBL EEX75933.1
OrganismSelenomonas sputigena (strain ATCC 35185 / DSM 20758 / VPI D19B-28) [Complete proteome] [HAMAP] EMBL EEX75933.1
Taxonomic identifier546271 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Negativicutes › Selenomonadales › Veillonellaceae › Selenomonas ›

Protein attributes

Sequence length809 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS005743 HAMAP-Rule MF_01897

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
C9LYV0 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: B71216898D20B91C

FASTA80989,870
        10         20         30         40         50         60 
MDFGEGKIVP VNLASEMKNS YIDYAMSVIV ARALPDVRDG LKPVHRRILY AMQEAGMGSG 

        70         80         90        100        110        120 
KPYKKSARIV GEVLGKYHPH GDSSVYDAIV RMAQDFSMRY MLADGHGNFG SVDGDPAAAM 

       130        140        150        160        170        180 
RYTEVRMSKV AELMLQDIDK ETVDFAPNYD ESLKEPTVLP AKFPQLLANG TAGIAVGMAT 

       190        200        210        220        230        240 
NIPPHNMREV IDGTLMLIDR PDATVEELMT VIKGPDFPTA GLILGTEGIR QAYTTGRGVI 

       250        260        270        280        290        300 
KLRARVHIET TSSGRSRIIV TELPYQVNKA RLVEKIAELV RDKAIEGITA LNDESDRSGM 

       310        320        330        340        350        360 
RIVIDVRRDA NANVILNQLY KHTQLQDSFG VIMLALVDGS PRVLTLKEVL HYYIKHQQDV 

       370        380        390        400        410        420 
ITRRTKYELA KAEARAHILE GLTIALDHLD AVITTIRESR TADIARERLM EDFKLSEKQA 

       430        440        450        460        470        480 
QAILDLRLQR LTGLEREKIE EEYQEVLKMI DWLKSVLADE GKIDKIIKDE LLAVREKYGD 

       490        500        510        520        530        540 
ERRTEITIDT SEINVEDLIA QEDVVITLTH NNYIKRMPLD TYRRQKRGGV GVTGMGTKEA 

       550        560        570        580        590        600 
DFVENILVTT THHTILFFTN RGRVYCLKAY EINEASRQAK GTAIINLLQL ESEEKITAVI 

       610        620        630        640        650        660 
QVKEFLPERY LFMATKKGIV KKTSLSEFQS IRRGGLNAIN LDEDDDLIGV KFTDGEKHVI 

       670        680        690        700        710        720 
LGTAGGMAVA FAEDDVRSMG RTARGVKGIN LKAGDVVVGM DNLARNAEVL TITAEGYGKR 

       730        740        750        760        770        780 
TATSEYRLQT RGGKGLINMK VTEKTGAVIG LKVVRPGQEL ILITTDGIVI RTKVDEISVI 

       790        800 
SRNTQGVKVV RLGEGDKAAS FAAMEQKNN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002637 Genomic DNA. Translation: AEC00933.1.
ACKP02000056 Genomic DNA. Translation: EEX75933.1.
RefSeqYP_004414392.1. NC_015437.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEC00933; AEC00933; Selsp_1983.
EEX75933; EEX75933; SELSPUOL_02661.
GeneID10498249.
KEGGssg:Selsp_1983.
PATRIC25828988. VBISelSpu76100_2301.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK02469.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC9LYV0_SELS3
AccessionPrimary (citable) accession number: C9LYV0
Entry history
Integrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: May 1, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info