ID   C9JYP7_HUMAN            Unreviewed;       106 AA.
AC   C9JYP7;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   SubName: Full=Interferon regulatory factor 5 {ECO:0000313|Ensembl:ENSP00000419056.1};
DE   Flags: Fragment;
GN   Name=IRF5 {ECO:0000313|Ensembl:ENSP00000419056.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000419056.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000419056.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000419056.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC025594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; C9JYP7; -.
DR   SMR; C9JYP7; -.
DR   MassIVE; C9JYP7; -.
DR   MaxQB; C9JYP7; -.
DR   PeptideAtlas; C9JYP7; -.
DR   ProteomicsDB; 12283; -.
DR   Antibodypedia; 17820; 701 antibodies from 45 providers.
DR   Ensembl; ENST00000464557.5; ENSP00000419056.1; ENSG00000128604.21.
DR   UCSC; uc064hwh.1; human.
DR   HGNC; HGNC:6120; IRF5.
DR   VEuPathDB; HostDB:ENSG00000128604; -.
DR   GeneTree; ENSGT00940000159926; -.
DR   HOGENOM; CLU_056386_3_1_1; -.
DR   OMA; WTGPCAG; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000128604; Expressed in monocyte and 135 other cell types or tissues.
DR   ExpressionAtlas; C9JYP7; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR   CDD; cd00103; IRF; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR019817; Interferon_reg_fac_CS.
DR   InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR   PANTHER; PTHR11949:SF10; INTERFERON REGULATORY FACTOR 5; 1.
DR   Pfam; PF00605; IRF; 1.
DR   PRINTS; PR00267; INTFRNREGFCT.
DR   SMART; SM00348; IRF; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00601; IRF_1; 1.
DR   PROSITE; PS51507; IRF_2; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|MaxQB:C9JYP7,
KW   ECO:0007829|PeptideAtlas:C9JYP7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          14..106
FT                   /note="IRF tryptophan pentad repeat"
FT                   /evidence="ECO:0000259|PROSITE:PS51507"
FT   NON_TER         106
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000419056.1"
SQ   SEQUENCE   106 AA;  12137 MW;  D4A537EA32A7F6A7 CRC64;
     MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD
     NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDG
//