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Protein
Submitted name:

Insulin-like growth factor-binding protein 5

Gene

IGFBP5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-like growth factor-binding protein 5Imported
Gene namesi
Name:IGFBP5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115461.4.
HGNCiHGNC:5474. IGFBP5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000115461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500299746521 – 233Sequence analysisAdd BLAST213

Proteomic databases

PeptideAtlasiC9JXX4.
PRIDEiC9JXX4.

Expressioni

Gene expression databases

BgeeiENSG00000115461.
ExpressionAtlasiC9JXX4. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliC9JXX4.
SMRiC9JXX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 103IGFBP N-terminalInterPro annotationAdd BLAST81

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.

Family and domain databases

InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_cys_sf.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
PANTHERiPTHR11551. PTHR11551. 2 hits.
PTHR11551:SF4. PTHR11551:SF4. 2 hits.
PfamiView protein in Pfam
PF00219. IGFBP. 1 hit.
PRINTSiPR01976. IGFBPFAMILY.
SMARTiView protein in SMART
SM00121. IB. 1 hit.
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiView protein in PROSITE
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

C9JXX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE
60 70 80 90 100
PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC
110 120 130 140 150
LNEKSYREQV KIGCAPGGQR HICFSLYYSP HPKLPSPGLW PCAPWPTGAD
160 170 180 190 200
PPAPSPAERD SREHEEPTTS EMAEETYSPK IFRPKHTRIS ELKAEAVKKD
210 220 230
RRKKLTQSKF VGGAENTAHP RIISAPEMRQ ESE
Length:233
Mass (Da):25,480
Last modified:November 3, 2009 - v1
Checksum:iEC741BD14C69859E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei233Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007563 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000449583; ENSP00000413474; ENSG00000115461.
UCSCiuc061sgh.1. human.

Entry informationi

Entry nameiC9JXX4_HUMAN
AccessioniPrimary (citable) accession number: C9JXX4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: November 22, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported