ID   C9JXS9_HUMAN            Unreviewed;        78 AA.
AC   C9JXS9;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   SubName: Full=Intersectin 1 {ECO:0000313|Ensembl:ENSP00000407132.1};
DE   Flags: Fragment;
GN   Name=ITSN1 {ECO:0000313|Ensembl:ENSP00000407132.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000407132.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000407132.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RG   Chromosome 21 mapping and sequencing consortium;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [2] {ECO:0000313|Ensembl:ENSP00000407132.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AP000308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; C9JXS9; -.
DR   SMR; C9JXS9; -.
DR   MassIVE; C9JXS9; -.
DR   PeptideAtlas; C9JXS9; -.
DR   ProteomicsDB; 12157; -.
DR   Antibodypedia; 7532; 106 antibodies from 19 providers.
DR   Ensembl; ENST00000451686.5; ENSP00000407132.1; ENSG00000205726.15.
DR   UCSC; uc061ztf.1; human.
DR   HGNC; HGNC:6183; ITSN1.
DR   VEuPathDB; HostDB:ENSG00000205726; -.
DR   GeneTree; ENSGT00940000157065; -.
DR   HOGENOM; CLU_2628255_0_0_1; -.
DR   OMA; XCSDLHL; -.
DR   ChiTaRS; ITSN1; human.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000205726; Expressed in sural nerve and 210 other cell types or tissues.
DR   ExpressionAtlas; C9JXS9; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00052; EH; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR000261; EH_dom.
DR   PANTHER; PTHR11216; EH DOMAIN; 1.
DR   PANTHER; PTHR11216:SF68; INTERSECTIN-1; 1.
DR   Pfam; PF12763; EF-hand_4; 1.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50031; EH; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Proteomics identification {ECO:0007829|EPD:C9JXS9,
KW   ECO:0007829|MaxQB:C9JXS9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          21..78
FT                   /note="EH"
FT                   /evidence="ECO:0000259|PROSITE:PS50031"
FT   DOMAIN          53..78
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   NON_TER         78
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000407132.1"
SQ   SEQUENCE   78 AA;  8812 MW;  25517C39A0DE9508 CRC64;
     MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ
     IWALADMNND GRMDQVEF
//