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Protein

Interleukin-1 beta

Gene

IL1B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.UniRule annotation

Miscellaneous

IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, MitogenUniRule annotation, PyrogenUniRule annotation
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 betaUniRule annotation
Gene namesi
Name:IL1BUniRule annotationImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000125538.11.
HGNCiHGNC:5992. IL1B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, Cytoplasmic vesicleUniRule annotation, LysosomeUniRule annotation, SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125538.

PTM / Processingi

Proteomic databases

MaxQBiC9JWV2.
PaxDbiC9JWV2.
PeptideAtlasiC9JWV2.
PRIDEiC9JWV2.

Expressioni

Gene expression databases

BgeeiENSG00000125538.
ExpressionAtlasiC9JWV2. baseline and differential.

Interactioni

Subunit structurei

Monomer. Interacts with MEFV.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliC9JWV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 103IL1_propepInterPro annotationAdd BLAST103

Sequence similaritiesi

Belongs to the IL-1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IGSZ. Eukaryota.
ENOG410XU2E. LUCA.
GeneTreeiENSGT00510000048687.
HOGENOMiHOG000246399.

Family and domain databases

InterProiView protein in InterPro
IPR003296. IL-1_beta.
IPR003502. IL-1_propep.
PANTHERiPTHR44849. PTHR44849. 1 hit.
PfamiView protein in Pfam
PF02394. IL1_propep. 1 hit.

Sequencei

Sequence statusi: Fragment.

C9JWV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL
60 70 80 90 100
RISDHHYSKG FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE
110 120 130 140
EPIFFDTWDN EAYVHDAPVR SLNCTLRDSQ QKSLVMSGPY ELK
Length:143
Mass (Da):16,393
Last modified:November 3, 2009 - v1
Checksum:iF93245AFC5D0F1E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei143Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079753 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000418817; ENSP00000407219; ENSG00000125538.
UCSCiuc061nbh.1. human.

Similar proteinsi

Entry informationi

Entry nameiC9JWV2_HUMAN
AccessioniPrimary (citable) accession number: C9JWV2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: December 20, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported