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Protein

Nuclear factor 1

Gene

NFIX

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 197CTF/NF-IPROSITE-ProRule annotationAdd BLAST194

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorPROSITE-ProRule annotation, DNA-bindingPROSITE-ProRule annotation
Biological processDNA replicationPROSITE-ProRule annotation, Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor 1UniRule annotation
Gene namesi
Name:NFIXImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000008441.16.
HGNCiHGNC:7788. NFIX.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000008441.

Expressioni

Gene expression databases

BgeeiENSG00000008441.
ExpressionAtlasiC9JWJ8. baseline and differential.

Interactioni

Subunit structurei

Binds DNA as a homodimer.UniRule annotation

Protein-protein interaction databases

IntActiC9JWJ8. 3 interactors.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 197CTF/NF-IInterPro annotationAdd BLAST194

Sequence similaritiesi

Belongs to the CTF/NF-I family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000009905.
HOGENOMiHOG000013028.

Family and domain databases

InterProiView protein in InterPro
IPR000647. CTF/NFI.
IPR020604. CTF/NFI_DNA-bd-dom.
IPR019739. CTF/NFI_DNA-bd_CS.
IPR019548. CTF/NFI_DNA-bd_N.
IPR003619. MAD_homology1_Dwarfin-type.
PANTHERiPTHR11492. PTHR11492. 2 hits.
PfamiView protein in Pfam
PF00859. CTF_NFI. 2 hits.
PF03165. MH1. 1 hit.
PF10524. NfI_DNAbd_pre-N. 1 hit.
SMARTiView protein in SMART
SM00523. DWA. 1 hit.
PROSITEiView protein in PROSITE
PS00349. CTF_NFI_1. 1 hit.
PS51080. CTF_NFI_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C9JWJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGATEPGGDT SSDEFHPFIE ALLPHVRAFS YTWFNLQARK RKYFKKHEKR
60 70 80 90 100
MSKDEERAVK DELLGEKPEI KQKWASRLLA KLRKDIRPEF REDFVLTITG
110 120 130 140 150
KKPPCCVLSN PDQKGKIRRI DCLRQADKVW RLDLVMVILF KGIPLESTDG
160 170 180 190 200
ERLYKSPQCS NPGLCVQPHH IGVTIKELDL YLAYFVHTPE SGQSDSSNQQ
210 220 230 240 250
GDADIKPLPN GHLSFQDCFV TSGVWNVTEL VRVSQTPVAT ASGPNFSLAD
260 270 280 290 300
LESPSYYNIN QVTLGRRSIT SPPSTSTTKR PKSIDDSEME SPVDDVFYPG
310 320 330 340 350
TGRSPAAGSS QSSGWPNDVD AGSPRATASA LHFPSTSIIQ QSSPYFTHPT
360 370 380 390 400
IRYHHHHGQD SLKEFVQFVC SDGSGQATGQ HSQRQAPPLP TGLSASDPGT

ATF
Length:403
Mass (Da):44,655
Last modified:October 29, 2014 - v2
Checksum:i4B31CBEFD9491F9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007787 Genomic DNA. No translation available.
AC022152 Genomic DNA. No translation available.
AC138474 Genomic DNA. No translation available.
KF456509 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000358552; ENSP00000351354; ENSG00000008441.
ENST00000360105; ENSP00000353219; ENSG00000008441.
UCSCiuc002mwf.3. human.

Similar proteinsi

Entry informationi

Entry nameiC9JWJ8_HUMAN
AccessioniPrimary (citable) accession number: C9JWJ8
Secondary accession number(s): X6R5U1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 29, 2014
Last modified: October 25, 2017
This is version 67 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported