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Protein
Submitted name:

Voltage-dependent calcium channel subunit alpha-2/delta-2

Gene

CACNA2D2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent calcium channel subunit alpha-2/delta-2Imported
Gene namesi
Name:CACNA2D2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1400. CACNA2D2.

PTM / Processingi

Proteomic databases

PaxDbiC9JVC9.
PRIDEiC9JVC9.

Expressioni

Gene expression databases

BgeeiC9JVC9.
ExpressionAtlasiC9JVC9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000418081.

Structurei

3D structure databases

ProteinModelPortaliC9JVC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini291 – 469179VWFAInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili123 – 14725Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2353. Eukaryota.
ENOG410XPDX. LUCA.
GeneTreeiENSGT00530000062904.
HOGENOMiHOG000004860.
OMAiNGYVFAI.
OrthoDBiEOG70GMDV.
PhylomeDBiC9JVC9.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR013680. VDCC_a2/dsu.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view]
PfamiPF08473. VGCC_alpha2. 1 hit.
PF00092. VWA. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9JVC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPARTCGA SRPGPARTAR PWPGCGPHPG PGTRRPTSGP PRPLWLLLPL
60 70 80 90 100
LPLLAAPGAS AYSFPQQHTM QHWARRLEQE VDGVMRIFGG VQQLREIYKD
110 120 130 140 150
NRNLFEVQEN EPQKLVEKVA GDIESLLDRK VQALKRLADA AENFQKAHRW
160 170 180 190 200
QDNIKEEDIV YYDAKADAEL DDPESEDVER GSKASTLRLD FIEDPNFKNK
210 220 230 240 250
VNYSYAAVQI PTDIYKGSTV ILNELNWTEA LENVFMENRR QDPTLLWQVF
260 270 280 290 300
GSATGVTRYY PATPWRAPKK IDLYDVRRRP WYIQGASSPK DMVIIVDVSG
310 320 330 340 350
SVSGLTLKLM KTSVCEMLDT LSDDDYVNVA SFNEKAQPVS CFTHLVQANV
360 370 380 390 400
RNKKVFKEAV QGMVAKGTTG YKAGFEYAFD QLQNSNITRA NCNKMIMMFT
410 420 430 440 450
DGGEDRVQDV FEKYNWPNRT VRVFTFSVGQ HNYDVTPLQW MACANKGYYF
460 470 480 490 500
EIPSIGAIRI NTQEYLDVLG RPMVLAGKEA KQVQWTNVYE DALGLGLVVT
510 520 530 540 550
GTLPVFNLTQ DGPGEKKNQL ILGVMGIDVA LNDIKRLTPN YTLGANGYVF
560 570 580 590 600
AIDLNGYVLL HPNLKPQTTN FREPVTLDFL DAELEDENKE EIRRSMIDGN
610 620 630 640 650
KGHKQIRTLV KSLDERYIDE VTRNYTWVPI RSTNYSLGLV LPPYSTFYLQ
660 670 680 690 700
ANLSDQILQV KLPISKLKDF EFLLPSSFES EGHVFIAPRE YCKDLNASDN
710 720 730 740 750
NTEFLKNFIE LMEKVTPDSK QCNNFLLHNL ILDTGITQQL VERVWRDQDL
760 770 780 790 800
NTYSLLAVFA ATDGGITRVF PNKAAEDWTE NPEPFNASFY RRSLDNHGYV
810 820 830 840 850
FKPPHQDALL RPLELENDTV GILVSTAVEL SLGRRTLRPA VVGVKLDLEA
860 870 880 890 900
WAEKFKVLAS NRTHQDQPQK QCGPNSHCEM DCEVNNEDLL CVLIDDGGFL
910 920 930 940 950
VLSNQNHQWD QVGRFFSEVD ANLMLALYNN SFYTRKESYD YQAACAPQPP
960 970 980 990 1000
GNLGAAPRGV FVPTVADFLN LAWWTSAAAW SLFQQLLYGL IYHSWFQADP
1010 1020 1030 1040 1050
AEAEGSPETR ESSCVMKQTQ YYFGSVNASY NAIIDCGNCS RLFHAQRLTN
1060 1070 1080 1090 1100
TNLLFVVAEK PLCSQCEAGR LLQKETHCPA DGPEQCELVQ RPRYRRGPHI
1110 1120 1130 1140 1150
CFDYNATEDT SDCGRGASFP PSLGVLVSLQ LLLLLGLPPR PQPQVLVHAS

RRL
Length:1,153
Mass (Da):130,130
Last modified:November 3, 2009 - v1
Checksum:i584DCE45863EC645
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450422 Genomic DNA. No translation available.
KF457634 Genomic DNA. No translation available.
Z75742 Genomic DNA. No translation available.
Z75743 Genomic DNA. No translation available.
Z84492 Genomic DNA. No translation available.
Z84494 Genomic DNA. No translation available.
Z84495 Genomic DNA. No translation available.
RefSeqiXP_011532544.1. XM_011534242.1.
UniGeneiHs.476273.
Hs.674666.

Genome annotation databases

EnsembliENST00000423994; ENSP00000407393; ENSG00000007402.
GeneIDi9254.
UCSCiuc062kfh.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450422 Genomic DNA. No translation available.
KF457634 Genomic DNA. No translation available.
Z75742 Genomic DNA. No translation available.
Z75743 Genomic DNA. No translation available.
Z84492 Genomic DNA. No translation available.
Z84494 Genomic DNA. No translation available.
Z84495 Genomic DNA. No translation available.
RefSeqiXP_011532544.1. XM_011534242.1.
UniGeneiHs.476273.
Hs.674666.

3D structure databases

ProteinModelPortaliC9JVC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000418081.

Proteomic databases

PaxDbiC9JVC9.
PRIDEiC9JVC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423994; ENSP00000407393; ENSG00000007402.
GeneIDi9254.
UCSCiuc062kfh.1. human.

Organism-specific databases

CTDi9254.
HGNCiHGNC:1400. CACNA2D2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2353. Eukaryota.
ENOG410XPDX. LUCA.
GeneTreeiENSGT00530000062904.
HOGENOMiHOG000004860.
OMAiNGYVFAI.
OrthoDBiEOG70GMDV.
PhylomeDBiC9JVC9.

Miscellaneous databases

ChiTaRSiCACNA2D2. human.
GenomeRNAii9254.

Gene expression databases

BgeeiC9JVC9.
ExpressionAtlasiC9JVC9. baseline and differential.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR013680. VDCC_a2/dsu.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view]
PfamiPF08473. VGCC_alpha2. 1 hit.
PF00092. VWA. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiC9JVC9_HUMAN
AccessioniPrimary (citable) accession number: C9JVC9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: June 8, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.