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Protein

Putative adrenomedullin-5-like protein

Gene

ADM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable non-functional remnant of adrenomedullin-5.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Putative adrenomedullin-5-like protein
Gene namesi
Name:ADM5
Synonyms:C19orf76
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:27293. ADM5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165393101.

Polymorphism and mutation databases

BioMutaiADM5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 153135Putative adrenomedullin-5-like proteinPRO_0000392551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 44By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiC9JUS6.
PeptideAtlasiC9JUS6.
PRIDEiC9JUS6.

Expressioni

Gene expression databases

BgeeiC9JUS6.
GenevisibleiC9JUS6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000393631.

Structurei

3D structure databases

ProteinModelPortaliC9JUS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JMZP. Eukaryota.
ENOG41116Z5. LUCA.
GeneTreeiENSGT00730000112484.
HOGENOMiHOG000170821.
InParanoidiC9JUS6.
OMAiAQCPARW.
OrthoDBiEOG7ZKSCR.
PhylomeDBiC9JUS6.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C9JUS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIHILILLL LLAFSAQGDL DTAARRGQHQ VPQHRGHVCY LGVCRTHRLA
60 70 80 90 100
EIIYWIRCLH QGALGEGQPR APGPLQLWAP PVARGGSPAR FPGFRPAARG
110 120 130 140 150
LAQCPARWVT SGTARPLLGF SLPICMLELL LHISSPLTPA PETVFPSPSP

GCD
Length:153
Mass (Da):16,532
Last modified:November 3, 2009 - v1
Checksum:i2AC1CFBEB867B30D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011495 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52522.1.
BC032764 mRNA. No translation available.
CCDSiCCDS46146.1.
RefSeqiNP_001094810.1. NM_001101340.1.
UniGeneiHs.311193.
Hs.607562.

Genome annotation databases

EnsembliENST00000420022; ENSP00000393631; ENSG00000224420.
GeneIDi199800.
KEGGihsa:199800.
UCSCiuc002pph.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011495 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52522.1.
BC032764 mRNA. No translation available.
CCDSiCCDS46146.1.
RefSeqiNP_001094810.1. NM_001101340.1.
UniGeneiHs.311193.
Hs.607562.

3D structure databases

ProteinModelPortaliC9JUS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000393631.

Polymorphism and mutation databases

BioMutaiADM5.

Proteomic databases

PaxDbiC9JUS6.
PeptideAtlasiC9JUS6.
PRIDEiC9JUS6.

Protocols and materials databases

DNASUi199800.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000420022; ENSP00000393631; ENSG00000224420.
GeneIDi199800.
KEGGihsa:199800.
UCSCiuc002pph.3. human.

Organism-specific databases

CTDi199800.
GeneCardsiADM5.
HGNCiHGNC:27293. ADM5.
neXtProtiNX_C9JUS6.
PharmGKBiPA165393101.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JMZP. Eukaryota.
ENOG41116Z5. LUCA.
GeneTreeiENSGT00730000112484.
HOGENOMiHOG000170821.
InParanoidiC9JUS6.
OMAiAQCPARW.
OrthoDBiEOG7ZKSCR.
PhylomeDBiC9JUS6.

Miscellaneous databases

GenomeRNAii199800.
PROiC9JUS6.

Gene expression databases

BgeeiC9JUS6.
GenevisibleiC9JUS6. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix carcinoma.
  4. "Central and peripheral cardiovascular actions of adrenomedullin 5, a novel member of the calcitonin gene-related peptide family, in mammals."
    Takei Y., Hashimoto H., Inoue K., Osaki T., Yoshizawa-Kumagaye K., Tsunemi M., Watanabe T.X., Ogoshi M., Minamino N., Ueta Y.
    J. Endocrinol. 197:391-400(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiADM5_HUMAN
AccessioniPrimary (citable) accession number: C9JUS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: November 3, 2009
Last modified: July 6, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.