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Protein
Submitted name:

ATP-binding cassette sub-family B member 8, mitochondrial

Gene

ABCB8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandATP-bindingImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette sub-family B member 8, mitochondrialImported
Submitted name:
ATP-binding cassette, sub-family B (MDR/TAP), member 8, isoform CRA_cImported
Gene namesi
Name:ABCB8Imported
ORF Names:hCG_18685Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000197150.12
HGNCiHGNC:49 ABCB8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei277 – 299HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197150

PTM / Processingi

Proteomic databases

MaxQBiC9JTY4
PeptideAtlasiC9JTY4

Expressioni

Gene expression databases

BgeeiENSG00000197150

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 409ABC transmembrane type-1InterPro annotationAdd BLAST277

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0058 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00550000074497
HOGENOMiHOG000168491

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
SUPFAMiSSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit

Sequencei

Sequence statusi: Complete.

C9JTY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVHLFRVGI RGGPFPGRLL PPLRFQTFSA VRYSDGYRSS SLLRAVAHLR
60 70 80 90 100
SQLWAHLPRA PLAPRWSPSA WCWVGGALLG PMVLSKHPHL CLVALCEAEE
110 120 130 140 150
APPASSTPHV VGSRFNWKLF WQFLHPHLLV LGVAVVLALG AALVNVQIPL
160 170 180 190 200
LLGQLVEVVA KYTRDHVGSF MTESQNLSTH LLILYGVQGL LTFGYLVLLS
210 220 230 240 250
HVGERMAVDM RRALFSSLLR QDITFFDANK TGQLVSRLTT DVQEFKSSFK
260 270 280 290 300
LVISQGLRSC TQVAGCLVSL SMLSTRLTLL LMVATPALMG VGTLMGSGLR
310 320 330 340 350
KLSRQCQEQI ARAMGVADEA LGNVRTVRAF AMEQREEERY GAELEACRCR
360 370 380 390 400
AEELGRGIAL FQGLSNIAFN CMVLGTLFIG GSLVAGQQLT GGDLMSFLVA
410 420 430
SQTVQSFLRV APCPNSLPLQ AVTFHAWKDH P
Length:431
Mass (Da):47,141
Last modified:November 3, 2009 - v1
Checksum:i44710D8361D9AD86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010973 Genomic DNA No translation available.
CH471173 Genomic DNA Translation: EAW54058.1
UniGeneiHs.647118

Genome annotation databases

EnsembliENST00000477092; ENSP00000419558; ENSG00000197150
UCSCiuc064jgd.1 human

Similar proteinsi

Entry informationi

Entry nameiC9JTY4_HUMAN
AccessioniPrimary (citable) accession number: C9JTY4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health