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Protein
Submitted name:

ATP-binding cassette sub-family B member 8, mitochondrial

Gene

ABCB8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandATP-bindingImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette sub-family B member 8, mitochondrialImported
Submitted name:
ATP-binding cassette, sub-family B (MDR/TAP), member 8, isoform CRA_cImported
Gene namesi
Name:ABCB8Imported
ORF Names:hCG_18685Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:49. ABCB8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei277 – 299HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197150.

PTM / Processingi

Proteomic databases

MaxQBiC9JTY4.

Expressioni

Gene expression databases

BgeeiENSG00000197150.
ExpressionAtlasiC9JTY4. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 409ABC transmembrane type-1InterPro annotationAdd BLAST277

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
HOGENOMiHOG000168491.

Family and domain databases

InterProiView protein in InterPro
IPR011527. ABC1_TM_dom.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
SUPFAMiSSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.

Sequencei

Sequence statusi: Complete.

C9JTY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVHLFRVGI RGGPFPGRLL PPLRFQTFSA VRYSDGYRSS SLLRAVAHLR
60 70 80 90 100
SQLWAHLPRA PLAPRWSPSA WCWVGGALLG PMVLSKHPHL CLVALCEAEE
110 120 130 140 150
APPASSTPHV VGSRFNWKLF WQFLHPHLLV LGVAVVLALG AALVNVQIPL
160 170 180 190 200
LLGQLVEVVA KYTRDHVGSF MTESQNLSTH LLILYGVQGL LTFGYLVLLS
210 220 230 240 250
HVGERMAVDM RRALFSSLLR QDITFFDANK TGQLVSRLTT DVQEFKSSFK
260 270 280 290 300
LVISQGLRSC TQVAGCLVSL SMLSTRLTLL LMVATPALMG VGTLMGSGLR
310 320 330 340 350
KLSRQCQEQI ARAMGVADEA LGNVRTVRAF AMEQREEERY GAELEACRCR
360 370 380 390 400
AEELGRGIAL FQGLSNIAFN CMVLGTLFIG GSLVAGQQLT GGDLMSFLVA
410 420 430
SQTVQSFLRV APCPNSLPLQ AVTFHAWKDH P
Length:431
Mass (Da):47,141
Last modified:November 3, 2009 - v1
Checksum:i44710D8361D9AD86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010973 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54058.1.
UniGeneiHs.647118.

Genome annotation databases

EnsembliENST00000477092; ENSP00000419558; ENSG00000197150.
UCSCiuc064jgd.1. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiC9JTY4_HUMAN
AccessioniPrimary (citable) accession number: C9JTY4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: July 5, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported