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Protein

Ankyrin repeat domain-containing protein 63

Gene

ANKRD63

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 63Imported
Gene namesi
Name:ANKRD63Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:40027. ANKRD63.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Ankyrin repeat domain-containing protein 63PRO_0000411002Add
BLAST

Proteomic databases

PaxDbiC9JTQ0.

Expressioni

Gene expression databases

BgeeiC9JTQ0.

Structurei

3D structure databases

ProteinModelPortaliC9JTQ0.
SMRiC9JTQ0. Positions 10-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 4030ANK 1Sequence AnalysisAdd
BLAST
Repeati46 – 7934ANK 2Sequence AnalysisAdd
BLAST
Repeati83 – 11230ANK 3Sequence AnalysisAdd
BLAST
Repeati116 – 14530ANK 4Sequence AnalysisAdd
BLAST
Repeati153 – 18230ANK 5Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00780000121964.
HOGENOMiHOG000231848.
InParanoidiC9JTQ0.
OMAiSIIDCRA.
OrthoDBiEOG7RRF7G.
PhylomeDBiC9JTQ0.
TreeFamiTF333311.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9JTQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKPKDLCPR AGTRTFLEAM QAGKVHLARF VLDALDRSII DCRAEQGRTP
60 70 80 90 100
LMVAVGLPDP ALRARFVRLL LEQGAAVNLR DERGRTALSL ACERGHLDAV
110 120 130 140 150
QLLVQFSGDP EAADSAGNSP VMWAAACGHG AVLEFLVRSF RRLGLRLDRT
160 170 180 190 200
NRAGLTALQL AAARGHGTCV QALTGPWGRA AAAAAARGSN SDSPPGRPAP
210 220 230 240 250
AASPEHRRPS PRRLPRPLLA RFARAAGGHG GEAGSAGKNS GRHRAQGSER
260 270 280 290 300
PELGRSMSLA LGAVTEEEAA RLRAGALMAL PNSPQSSGTG RWRSQEVLEG
310 320 330 340 350
APPTLAQAPI GLSPHPEGGP GSGRLGLRRR STAPDIPSLV GEAPGPESGP
360 370 380
ELEANALSVS VPGPNPWQAG TEAVVLRAQR
Length:380
Mass (Da):39,620
Last modified:November 2, 2009 - v1
Checksum:i68DE84AAC8CD0106
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020658 Genomic DNA. No translation available.
RefSeqiNP_001177408.1. NM_001190479.1.
UniGeneiHs.711376.

Genome annotation databases

EnsembliENST00000434396; ENSP00000399547; ENSG00000230778.
GeneIDi100131244.
KEGGihsa:100131244.
UCSCiuc021sjf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020658 Genomic DNA. No translation available.
RefSeqiNP_001177408.1. NM_001190479.1.
UniGeneiHs.711376.

3D structure databases

ProteinModelPortaliC9JTQ0.
SMRiC9JTQ0. Positions 10-173.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiC9JTQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434396; ENSP00000399547; ENSG00000230778.
GeneIDi100131244.
KEGGihsa:100131244.
UCSCiuc021sjf.1. human.

Organism-specific databases

CTDi100131244.
GeneCardsiGC15M040574.
HGNCiHGNC:40027. ANKRD63.
neXtProtiNX_C9JTQ0.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00780000121964.
HOGENOMiHOG000231848.
InParanoidiC9JTQ0.
OMAiSIIDCRA.
OrthoDBiEOG7RRF7G.
PhylomeDBiC9JTQ0.
TreeFamiTF333311.

Miscellaneous databases

GenomeRNAii100131244.
NextBioi20773248.
PROiC9JTQ0.

Gene expression databases

BgeeiC9JTQ0.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiANR63_HUMAN
AccessioniPrimary (citable) accession number: C9JTQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2011
Last sequence update: November 2, 2009
Last modified: February 3, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.