C9JR60 (C9JR60_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Probable ATP-dependent RNA helicase DHX40 Ensembl ENSP00000388749

Gene names

Name:

DHX40 Ensembl ENSP00000388749

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000388749

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	702 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities	Contains 1 helicase ATP-binding domain. SAAS SAAS007502 Contains 1 helicase C-terminal domain. SAAS SAAS007502
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000388749

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS007502 Nucleotide-binding
Molecular function	Hydrolase SAAS SAAS007502
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C9JR60 [UniParc]. Last modified October 3, 2012. Version 3. Checksum: DE23745E99819ED8	FASTA	702	80,221
	10 20 30 40 50 60 MSRFPAVAGR APRRQEEGER SRDLQEERLS AVCIADREEK GCTSQEGGTT PTFPIQKQRK 70 80 90 100 110 120 KIIQAETAIK YMTDGCLLKH ILGDPNLTKF SVIILDEAHE RTLTTDILFG LLKKLFQEKS 130 140 150 160 170 180 PNRKEHLKVV VMSATMELAK LSAFFGNCPI FDIPGRLYPV REKFCNLIGP RDRENTAYIQ 190 200 210 220 230 240 AIVKVTMDIH LNEMAGDILV FLTGQFEIEK SCELLFQMAE SVDYDYDVQD TTLDGLLILP 250 260 270 280 290 300 CYGSMTTDQQ RRIFLPPPPG IRKCVISTNI SATSLTIDGI RYVVDGGFVK QLNHNPRLGL 310 320 330 340 350 360 DILEVVPISK SEALQRSGRA GRTSSGKCFR IYSKDFWNQC MPDHVIPEIK RTSLTSVVLT 370 380 390 400 410 420 LKCLAIHDVI RFPYLDPPNE RLILEALKQL YQCDAIDRSG HVTRLGLSMV EFPLPPHLTC 430 440 450 460 470 480 AVIKAASLDC EDLLLPIAAM LSVENVFIRP VDPEYQKEAE QRHRELAAKA GGFNDFATLA 490 500 510 520 530 540 VIFEQCKSSG APASWCQKHW IHWRCLFSAF RVEAQLRELI RKLKQQSDFP KETFEGPKHE 550 560 570 580 590 600 VLRRCLCAGY FKNVARRSVG RTFCTMDGRG SPVHIHPSSA LHEQETKLEW IIFHEVLVTT 610 620 630 640 650 660 KVYARIVCPI RYEWVRDLLP KLHEFNAHDL SSVARREVRE DARRRWTNKE NVKQLKDGIS 670 680 690 700 KDVLKKMQRR NDDKSISDAR ARFLERKQQR TQDHSDTRKE TG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC004167 Genomic DNA. No translation available. AC091271 Genomic DNA. No translation available.
IPI	IPI00952676.
RefSeq	NP_001159773.1. NM_001166301.1.
UniGene	Hs.29403.
3D structure databases
ProteinModelPortal	C9JR60.
SMR	C9JR60. Positions 25-644.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000425628; ENSP00000388749; ENSG00000108406.
GeneID	79665.
KEGG	hsa:79665.
Organism-specific databases
CTD	79665.
HGNC	HGNC:18018. DHX40.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000175261.
OrthoDB	EOG48PMJH.
Family and domain databases
InterPro	IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR011709. DUF1605. IPR007502. Helicase-assoc_dom. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF04408. HA2. 1 hit. PF00271. Helicase_C. 1 hit. PF07717. OB_NTP_bind. 1 hit. [Graphical view]
SMART	SM00847. HA2. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00690. DEAH_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DHX40. human.
GenomeRNAi	79665.
NextBio	35487494.

Entry information

Entry name

C9JR60_HUMAN

Accession

Primary (citable) accession number: C9JR60

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	October 3, 2012
Last modified:	May 29, 2013
This is version 32 of the entry and version 3 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.